Browsing by Subject "Bufeta -- Càncer"

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  • López De Maturana, Evangelina; Ye, Yuanqing; Calle, M. Luz; Rothman, Nathaniel; Urrea, Víctor; Kogevinas, Manolis; Petrus, Sandra; Chanock, Stephen J.; Tardón, Adonina; García Closas, Montserrat; González Neira, Anna; Vellalta, Gemma; Carrato, Alfredo; Navarro i Cuartiellas, Arcadi, 1969-; Lorente-Galdós, Belén, 1981-; Silverman, Debra T.; Real, Francisco X.; Wu, Xifeng; Malats i Riera, Núria (Public Library of Science (PLoS), 2013)
    The relationship between inflammation and cancer is well established in several tumor types, including bladder cancer. We performed an association study between 886 inflammatory-gene variants and bladder cancer risk in ...
  • Schmidt, Stefanie, 1979-; Riel, Ricard; Frances, Albert; Lorente Garin, José Antonio; Bonfill, Xavier; Martínez Zapata, María José; Morales Suárez-Varela, María; Cruz, Javier de la; Emparanza, José Ignacio; Sánchez, María José; Zamora, Javier; Goñi, Juan Manuel Ramos; Alonso Caballero, Jordi; Ferrer Forés, Maria Montserrat; EMPARO-CU Study Group (BioMed Central, 2014)
    Background: The Bladder Cancer Index (BCI) is so far the only instrument applicable across all bladder cancer patients, independent of tumor infiltration or treatment applied. We developed a Spanish version of the BCI, and ...
  • Lerner, Seth; McConkey, David; Hoadley, Katherine A.; Chan, Keith S.; Kim, William Y.; Radvanyi, François; Höglund, Mattias; Real, Francisco X. (IOS Press, 2016)
    The advent of Omics technologies has been key to the molecular subclassification of urothelial bladder cancer. Several groups have used different strategies to this aim, with partially overlapping findings. The meeting at ...
  • del Rey, Javier; Prat, Esther; Ponsa, Immaculada; Lloreta Trull, Josep, 1958-; Gelabert, Antoni; Algaba, Ferran; Camps, Jordi; Miró, Rosa (BioMed Central, 2010)
    Background: Aneuploidy, centrosome abnormalities and gene amplification are hallmarks of chromosome instability (CIN) in cancer. Yet there are no studies of the in vivo behavior of these phenomena within the same bladder ...
  • Bonfill, Xavier; Martínez Zapata, María José; Vernooij, Robin W. M.; Sánchez, María José; Morales Suárez-Varela, María; de la Cruz, Javier; Emparanza, José Ignacio; Ferrer Forés, Montserrat; Pijoán, José Ignacio; Palou, Joan; Schmidt, Stefanie, 1979-; Madrid, Eva; Abraira, Víctor; Zamora, Javier; EMPARO CU study group (BioMed Central, 2017)
    OBJECTIVE: We performed a cohort study in seven hospitals in Spain to determine the clinical characteristics of incident patients with bladder cancer, the diagnostic process, and the conditions that might affect health ...
  • Earl, Julie; Rico, Daniel; Carrillo, Enrique; Rodríguez Santiago, Benjamín; Méndez Pertuz, Marinela; Auer, Herbert; Gómez, Gonzalo; Barton Grossman, Herbert; Pisano, David G.; Schulz, Wolfgang; Pérez Jurado, Luis Alberto; Carrato, Alfredo; Theodorescu, Dan; Chanock, Stephen J.; Valencia, Alfonso; Real, Francisco X. (BioMed Central, 2015)
    Following the publication of our recent article in BMC Genomics [1] a number of aspects were called to our attention. We have carefully reviewed the experiments reported in this manuscript, as well as additional data from ...
  • Lloreta Trull, Josep, 1958-; Font-Tello, Alba; Juanpere, Nuria; Frances, Albert; Lorenzo Perez, Marta; Nonell Mazelón, Lara; Muga, Silvia de; Vázquez‐de las Heras, Ivonne; Cecchini Rosell, Lluís; Hernández, Silvia (Elsevier, 2017)
    Nuclear FOXOs mediate cell cycle arrest and promote apoptosis. FOXOs and p53 could have similar effects as tumor suppressor genes. In spite of extensive literature, little is known about the role of FOXO1 and its relationship ...
  • Choi, Woonyoung; Ochoa, Andrea; McConkey, David; Aine, Mattias; Höglund, Mattias; Kim, William Y.; Real, Francisco X.; Kiltie, Anne E.; Milsom, Ian; Dyrskjot, Lars; Lerner, Seth (Elsevier, 2017)
    CONTEXT: Recent whole genome mRNA expression profiling studies revealed that bladder cancers can be grouped into molecular subtypes, some of which share clinical properties and gene expression patterns with the intrinsic ...
  • Marenne, Gaëlle; Real, Francisco X.; Rothman, Nathaniel; Rodríguez Santiago, Benjamín; Pérez Jurado, Luis Alberto; Kogevinas, Manolis; García Closas, Montserrat; Silverman, Debra T.; Chanock, Stephen J.; Génin, Emmanuelle; Malats i Riera, Núria (BioMed Central, 2012)
    BACKGROUND: Structural variations such as copy number variants (CNV) influence the expression of different phenotypic traits. Algorithms to identify CNVs through SNP-array platforms are available. The ability to evaluate ...
  • Moore, Lee E.; Pfeiffer, Ruth M.; Poscablo, Cristina; Real, Francisco X.; Kogevinas, Manolis; Silverman, Debra T.; García Closas, Reina; Chanock, Stephen J.; Tardón, Adonina; Serra, Consol; Carrato, Alfredo; Dosemeci, Mustafa; García Closas, Montserrat; Esteller, Manel; Fraga, Mario F.; Rothman, Nathaniel; Malats i Riera, Núria (Elsevier, 2008)
    BACKGROUND: DNA hypomethylation has been suggested to cause genomic instability and increase cancer risk. We aimed to test the hypothesis that DNA hypomethylation is associated with increased risk of bladder cancer. METHODS: ...
  • Selinski, Silvia; Kogevinas, Manolis; Golka, Klaus (Oxford University Press, 2017)
    Little is known whether genetic variants identified in genome-wide association studies interact to increase bladder cancer risk. Recently, we identified two- and three-variant combinations associated with a particular ...
  • Salas, Lucas A.; Villanueva Belmonte, Cristina; Tajuddin, Salman Muhammad; Amaral, André F.S.; Fernández, Agustín F.; Moore, Lee E.; Carrato, Alfredo; Tardón, Adonina; Serra, Consol; García Closas, Reina; Basagaña Flores, Xavier; Rothman, Nathaniel; Silverman, Debra T.; Cantor, Kenneth P; Kogevinas, Manolis; Real, Francisco X.; Fraga, Mario F.; Malats i Riera, Núria (Taylor & Francis (Routledge), 2014)
    DNA methylation changes contribute to bladder carcinogenesis. Trihalomethanes (THM), a class of disinfection by-products, are associated with increased urothelial bladder cancer (UBC) risk. THM exposure in animal models ...
  • Amaral, André F.S.; Tajuddin, Salman Muhammad; Fernández, Agustín F.; Chanock, Stephen J.; Silverman, Debra T.; Tardón, Adonina; Carrato, Alfredo; García Closas, Montserrat; Jackson, Brian P.; Toraño, Estela; Márquez, Miriam; González Urdinguio, Rocío; García Closas, Reina; Rothman, Nathaniel; Kogevinas, Manolis; Real, Francisco X.; Fernández Fraga, Mario; Malats i Riera, Núria (Cancer Research UK, 2014)
    Background: Aberrant global DNA methylation is shown to increase cancer risk. LINE-1 has been proven a measure of global DNA methylation. The objectives of this study were to assess the association between LINE-1 methylation ...
  • García Closas, Montserrat; Malats i Riera, Núria; Kogevinas, Manolis; Serra, Consol; Lloreta Trull, Josep, 1958-; Castaño Vinyals, Gemma; Torà, Montserrat; Fernández-Avilés, Francisco; Real, Francisco X.; Rothman, Nathaniel (Elsevier, 2005)
    BACKGROUND: Many reported associations between common genetic polymorphisms and complex diseases have not been confirmed in subsequent studies. An exception could be the association between NAT2 slow acetylation, GSTM1 ...
  • Vedder, Moniek M.; Márquez, Mirari; De Bekker-Grob; Calle, M. Luz; Dyrskjot, Lars; Kogevinas, Manolis; Segersten, Ulrika; Malmström, Per-Uno; Algaba, Ferran; Beukers, Willemien; Orntoft, Torben F.; Zwarthoff, Ellen; Real, Francisco X.; Malats i Riera, Núria (Public Library of Science (PLoS), 2014)
    Objective: We aimed to determine the validity of two risk scores for patients with non-muscle invasive bladder cancer in different European settings, in patients with primary tumours. Methods: We included 1,892 patients ...
  • Bellmunt Molins, Joaquim (MDPI, 2018)
    The rapid development of the cancer stem cells (CSC) field, together with powerful genome-wide screening techniques, have provided the basis for the development of future alternative and reliable therapies aimed at targeting ...
  • Casadevall Aguilar, David; Kilian, Anaïs Yacine; Bellmunt Molins, Joaquim, 1959- (Elsevier, 2017)
    BACKGROUND: Despite adequate treatment and follow-up, around one fifth of patients with localized bladder cancer will present with disease progression. Adequate prognostic biomarkers are lacking to define patients who are ...
  • Ramos, Jorge D.; Bellmunt Molins, Joaquim, 1959-; Yu, Evan Y. (Wiley, 2017)
    Venous thromboembolism (VTE) is common in cancer patients. However, little is known about VTE risk in metastatic urothelial carcinoma or variant histologies (UC/VH). We sought to characterize the incidence, associative ...
  • Ramos, Jorge D.; Wingate, Jonathan T.; Gulati, Roman; Plimack, Elizabeth R.; Harshman, Lauren C.; Powles, Thomas; Crabb, Simon J.; Niegisch, Guenter; Bellmunt Molins, Joaquim, 1959-; Ladoire, Sylvain; De Giorgi, Ugo; Hussain, Syed; Alva, Ajjai S.; Baniel, Jack; Agarwal, Neeraj; Rosenberg, Jonathan; Vaishampayan, Ulka N.; Galsky, Matthew D.; Yu, Evan Y. (Elsevier, 2018)
    BACKGROUND: Venous thromboembolism (VTE) is common in cancer patients, but there is limited data on patients with urothelial tract tumors (UTT). We previously identified several associative factors for increased VTE rates ...