Browsing by Subject "B-cell lymphoma"

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  • Detection of early seeding of Richter transformation in chronic lymphocytic leukemia
    Nadeu, Ferran; Massoni-Badosa, Ramon; Ruiz Gil, Sara; Marchese, Domenica, 1986-; López Bigas, Núria; Gut, Ivo Glynne; Heyn, Holger; Campo, Elias (Nature Research, 2022)
    Richter transformation (RT) is a paradigmatic evolution of chronic lymphocytic leukemia (CLL) into a very aggressive large B cell lymphoma conferring a dismal prognosis. The mechanisms driving RT remain largely unknown. ...
  • DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia
    Georgiadis, Panagiotis; Gavriil, Marios; Rantakokko, Panu; Ladoukakis, Efthymios; Botsivali, Maria; Kelly, Rachel S.; Bergdahl, Ingvar A.; Kiviranta, Hannu; Vermeulen, Roel; Spaeth, Florentin; Hebbels, Dennie G. A. J.; Kleinjans, Jos C.; Kok, Theo M. de; Palli, Domenico; Vineis, Paolo; Kyrtopoulos, Sosterios A.; EnviroGenomarkers consortium (Elsevier, 2019)
    Objectives: To characterize the impact of PCB exposure on DNA methylation in peripheral blood leucocytes and to evaluate the corresponding changes in relation to possible health effects, with a focus on B-cell lymphoma. ...
  • Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets
    Karube, Kennosuke; Rubio Pérez, Carlota, 1990-; Tamborero Noguera, David; Salar Silvestre, Antonio; Colomo Saperas, Luis Alberto; López Bigas, Núria; Miyoshi, Hiroaki (Nature Publishing Group, 2018)
    Genome studies of diffuse large B-cell lymphoma (DLBCL) have revealed a large number of somatic mutations and structural alterations. However, the clinical significance of these alterations is still not well defined. In ...