Browsing by Author "Zorita, Eduard"

Sort by: Order: Results:

  • Filion, Guillaume; Cortini, Ruggero; Zorita, Eduard (Frontiers, 2020)
    The increasing throughput of DNA sequencing technologies creates a need for faster algorithms. The fate of most reads is to be mapped to a reference sequence, typically a genome. Modern mappers rely on heuristics to gain ...
  • Chen, Heng-Chang; Martínez Vesga, Javier Pablo; Zorita, Eduard; Meyerhans, Andreas; Filion, Guillaume (Nature Publishing Group, 2017)
    The main obstacle to curing HIV is the presence of latent proviruses in the bodies of infected patients. The partial success of reactivation therapies suggests that the genomic context of integrated proviruses can interfere ...
  • Lucic, Bojana; Chen, Heng-Chang; Kuzman, Maja; Zorita, Eduard; Wegner, Julia; Minneker, Vera; Wang, Wei; Fronza, Raffaele; Laufs, Stefanie; Schmidt, Manfred; Stadhouders, Ralph; Roukos, Vassilis; Vlahovicek, Kristian; Filion, Guillaume; Lusic, Marina (Nature Research, 2019)
    HIV-1 recurrently targets active genes and integrates in the proximity of the nuclear pore compartment in CD4+ T cells. However, the genomic features of these genes and the relevance of their transcriptional activity for ...
  • Zorita, Eduard; Cuscó Pons, Pol, 1987-; Filion, Guillaume (Oxford University Press, 2015)
    Motivation: The increasing throughput of sequencing technologies offers new applications and challenges for computational biology. In many of those applications, sequencing errors need to be/ncorrected. This is particularly ...
  • Vansant, Gerlinde; Chen, Heng-Chang; Zorita, Eduard; Trejbalová, Katerina; Miklík, Dalibor; Filion, Guillaume; Debyser, Zeger (Oxford University Press, 2020)
    HIV-1 persists lifelong in memory cells of the immune system as latent provirus that rebounds upon treatment interruption. Therefore, the latent reservoir is the main target for an HIV cure. Here, we studied the direct ...