Browsing by Author "Zorita, Eduard"

Sort by: Order: Results:

  • Calibrating seed-based heuristics to map short reads with sesame
    Filion, Guillaume; Cortini, Ruggero; Zorita, Eduard (Frontiers, 2020)
    The increasing throughput of DNA sequencing technologies creates a need for faster algorithms. The fate of most reads is to be mapped to a reference sequence, typically a genome. Modern mappers rely on heuristics to gain ...
  • Chromosome compartments on the inactive X guide TAD formation independently of transcription during X-reactivation
    Bauer, Moritz, 1987-; Vidal, Enrique; Zorita, Eduard; Üresin, Nil; Pinter, Stefan F.; Filion, Guillaume; Payer, Bernhard (Nature Research, 2021)
    A hallmark of chromosome organization is the partition into transcriptionally active A and repressed B compartments, and into topologically associating domains (TADs). Both structures were regarded to be absent from the ...
  • Position effects influence HIV latency reversal
    Chen, Heng-Chang; Martínez Vesga, Javier Pablo; Zorita, Eduard; Meyerhans, Andreas; Filion, Guillaume (Nature Publishing Group, 2017)
    The main obstacle to curing HIV is the presence of latent proviruses in the bodies of infected patients. The partial success of reactivation therapies suggests that the genomic context of integrated proviruses can interfere ...
  • Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration
    Lucic, Bojana; Chen, Heng-Chang; Kuzman, Maja; Zorita, Eduard; Wegner, Julia; Minneker, Vera; Wang, Wei; Fronza, Raffaele; Laufs, Stefanie; Schmidt, Manfred; Stadhouders, Ralph; Roukos, Vassilis; Vlahovicek, Kristian; Filion, Guillaume; Lusic, Marina (Nature Research, 2019)
    HIV-1 recurrently targets active genes and integrates in the proximity of the nuclear pore compartment in CD4+ T cells. However, the genomic features of these genes and the relevance of their transcriptional activity for ...
  • Starcode: sequence clustering based on all-pairs search
    Zorita, Eduard; Cuscó Pons, Pol, 1987-; Filion, Guillaume (Oxford University Press, 2015)
    Motivation: The increasing throughput of sequencing technologies offers new applications and challenges for computational biology. In many of those applications, sequencing errors need to be/ncorrected. This is particularly ...
  • The chromatin landscape at the HIV-1 provirus integration site determines viral expression
    Vansant, Gerlinde; Chen, Heng-Chang; Zorita, Eduard; Trejbalová, Katerina; Miklík, Dalibor; Filion, Guillaume; Debyser, Zeger (Oxford University Press, 2020)
    HIV-1 persists lifelong in memory cells of the immune system as latent provirus that rebounds upon treatment interruption. Therefore, the latent reservoir is the main target for an HIV cure. Here, we studied the direct ...

Search DSpace

Browse

My Account

In collaboration with Compliant to Partaking