Browsing by Author "Zetterberg, Henrik"

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  • Age, sex and APOE-ε4 modify the balance between soluble and fibrillar β-amyloid in non-demented individuals: topographical patterns across two independent cohorts
    Cacciaglia, Raffaele; Salvadó, Gemma; Molinuevo, José Luis; Shekari, Mahnaz; Falcón, Carles; Operto, Grégory; Suárez-Calvet, Marc; Milà Alomà, Marta; Sala, Arianna; Rodriguez-Vieitez, Elena; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Blennow, Kaj; Zetterberg, Henrik; Gispert López, Juan Domingo; Alzheimer’s Disease Neuroimaging Initiative; ALFA Study (Nature Research, 2022)
    Amyloid (Aβ) pathology is the earliest detectable pathophysiological event along the Alzheimer's continuum, which can be measured both in the cerebrospinal fluid (CSF) and by Positron Emission Tomography (PET). Yet, these ...
  • Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum
    Milà Alomà, Marta; Salvadó, Gemma; Gispert López, Juan Domingo; Vilor Tejedor, Natàlia, 1988-; Grau-Rivera, Oriol; Sala Vila, Aleix; Sánchez Benavides, Gonzalo; Arenaza Urquijo, Eider M.; Crous-Bou, Marta; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Molinuevo, José Luis; ALFA Study (Wiley, 2020)
    Introduction: The biological pathways involved in the preclinical stage of the Alzheimer's continuum are not well understood. Methods: We used NeuroToolKit and Elecsys® immunoassays to measure cerebrospinal fluid (CSF) ...
  • Amyloid-β positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to lower hippocampal volume
    Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Milà Alomà, Marta; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Operto, Grégory; Domingo Gispert, Juan; Vilor Tejedor, Natàlia, 1988-; Sala Vila, Aleix; Crous-Bou, Marta; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Molinuevo, José Luis; ALFA Study (Elsevier, 2021)
    Neurofilament light chain (NfL) is an axonal protein that when measured in cerebrospinal fluid (CSF) serves as a biomarker of neurodegeneration. We aimed at investigating the association among CSF NfL, presence of Subjective ...
  • APOE-ε4 shapes the cerebral organization in cognitively intact individuals as reflected by structural gray matter networks
    Cacciaglia, Raffaele; Molinuevo, José Luis; Falcón, Carles; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Brugulat Serrat, Anna, 1986-; Blennow, Kaj; Zetterberg, Henrik; Gispert López, Juan Domingo; ALFA Study (Oxford University Press, 2020)
    Gray matter networks (GMn) provide essential information on the intrinsic organization of the brain and appear to be disrupted in Alzheimer's disease (AD). Apolipoprotein E (APOE)-ε4 represents the major genetic risk factor ...
  • Association between polygenic risk score of Alzheimer's disease and plasma phosphorylated tau in individuals from the Alzheimer's disease neuroimaging initiative
    Zettergren, Anna; Lord, Jodie; Ashton, Nicholas J.; Benedet, Andrea L.; Karikari, Thomas K.; Lantero Rodriguez, Juan; Alzheimer’s Disease Neuroimaging Initiative; Snellman, Anniina; Suárez-Calvet, Marc; Proitsi, Petroula; Zetterberg, Henrik; Blennow, Kaj (BioMed Central, 2021)
    Background: Recent studies suggest that plasma phosphorylated tau181 (p-tau181) is a highly specific biomarker for Alzheimer's disease (AD)-related tau pathology. It has great potential for the diagnostic and prognostic ...
  • Association of weight change with cerebrospinal fluid biomarkers and amyloid positron emission tomography in preclinical Alzheimer's disease
    Grau-Rivera, Oriol; Navalpotro Gómez, Irene; Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Milà Alomà, Marta; Arenaza Urquijo, Eider M.; Salvadó, Gemma; Sala Vila, Aleix; Shekari, Mahnaz; González de Echávarri, José Maria; Minguillón, Carolina; Niñerola-Baizán, Aida; Perissinotti, Andrés; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (BioMed Central, 2021)
    Background: Recognizing clinical manifestations heralding the development of Alzheimer's disease (AD)-related cognitive impairment could improve the identification of individuals at higher risk of AD who may benefit from ...
  • Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers
    Salvadó, Gemma; Molinuevo, José Luis; Brugulat Serrat, Anna, 1986-; Falcón, Carles; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Pavía Segura, Javier; Niñerola-Baizán, Aida; Perissinotti, Andrés; Lomeña, Francisco; Minguillón, Carolina; Fauria, Karine; Zetterberg, Henrik; Blennow, Kaj; Gispert López, Juan Domingo; Alzheimer’s Disease Neuroimaging Initiative (BioMed Central, 2019)
    Background: The Centiloid scale has been developed to standardize measurements of amyloid PET imaging. Reference cut-off values of this continuous measurement enable the consistent operationalization of decision-making for ...
  • Cerebral amyloid-β load is associated with neurodegeneration and gliosis: Mediation by p-tau and interactions with risk factors early in the Alzheimer's continuum
    Salvadó, Gemma; Milà Alomà, Marta; Shekari, Mahnaz; Minguillón, Carolina; Fauria, Karine; Niñerola-Baizán, Aida; Perissinotti, Andrés; Kollmorgen, Gwendlyn; Buckley, Christopher, 1948-; Farrar, Gill; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Wiley, 2021)
    Introduction: The association between cerebral amyloid-β accumulation and downstream CSF biomarkers is not fully understood, particularly in asymptomatic stages. Methods: In 318 cognitively unimpaired participants, we ...
  • CSF synaptic biomarkers in the preclinical stage of Alzheimer disease and their association with MRI and PET: a cross-sectional study
    Milà Alomà, Marta; Brinkmalm, Ann; Ashton, Nicholas J.; Kvartsberg, Hlin; Shekari, Mahnaz; Operto, Grégory; Salvadó, Gemma; Falcon, Carles; Domingo Gispert, Juan; Vilor Tejedor, Natàlia, 1988-; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Sala Vila, Aleix; Sanchez-Benavides, Gonzalo; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Niñerola-Baizán, Aida; Perissinotti, Andrés; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Zetterberg, Henrik; Molinuevo, José Luis; Blennow, Kaj; Suárez-Calvet, Marc; ALFA Study (Lippincott Williams & Wilkins, 2021)
    Background and objectives: To determine whether CSF synaptic biomarkers are altered in the early preclinical stage of the Alzheimer continuum and associated with Alzheimer disease (AD) risk factors, primary pathology, and ...
  • Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the alzheimer's disease neuroimaging initiative
    Karikari, Thomas K.; Benedet, Andrea L.; Ashton, Nicholas J.; Lantero Rodríguez, Juan; Snellman, Anniina; Suárez-Calvet, Marc; Saha-Chaudhuri, Paramita; Lussier, Firoza; Kvartsberg, Hlin; Moscoso Rial, Alexis; Pascoal, Tharick A.; Andreasson, Ulf; Schöll, Michael; Weiner, Michael W.; Rosa-Neto, Pedro; Trojanowski, John Q.; Shaw, Leslie M.; Blennow, Kaj; Zetterberg, Henrik; Alzheimer’s Disease Neuroimaging Initiative (Nature Research, 2021)
    Whilst cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers for amyloid-β (Aβ) and tau pathologies are accurate for the diagnosis of Alzheimer's disease (AD), their broad implementation in clinical ...
  • Differential effects of sleep on brain structure and metabolism at the preclinical stages of AD
    Stankeviciute, Laura; Falcón, Carles; Operto, Grégory; Garcia, Marina; Shekari, Mahnaz; Iranzo, Alex; Niñerola-Baizán, Aida; Perissinotti, Andrés; Minguillón, Carolina; Fauria, Karine; Molinuevo, José Luis; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Cacciaglia, Raffaele; Gispert López, Juan Domingo; Grau-Rivera, Oriol; ALFA Study (Wiley, 2023)
    Introduction: Poor sleep quality is associated with cognitive outcomes in Alzheimer's disease (AD). We analyzed the associations between self-reported sleep quality and brain structure and function in cognitively unimpaired ...
  • Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation
    Skouras, Stavros; Torner, Jordi; Andersson, Patrik; Koush, Yury; Falcón, Carles; Minguillón, Carolina; Fauria, Karine; Alpiste, Francesc; Blenow, Kaj; Zetterberg, Henrik; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (Oxford University Press, 2020)
    Research into hippocampal self-regulation abilities may help determine the clinical significance of hippocampal hyperactivity throughout the pathophysiological continuum of Alzheimer's disease. In this study, we aimed to ...
  • Effects of pre-analytical procedures on blood biomarkers for Alzheimer's pathophysiology, glial activation, and neurodegeneration
    Ashton, Nicholas J.; Suárez-Calvet, Marc; Karikari, Thomas K.; Lantero Rodriguez, Juan; Snellman, Anniina; Sauer, Mathias; Simrén, Joel; Minguillón, Carolina; Fauria, Karine; Blennow, Kaj; Zetterberg, Henrik (Wiley, 2021)
    Introduction: We tested how tube types (ethylenediaminetetraacetic acid [EDTA], serum, lithium heparin [LiHep], and citrate) and freeze-thaw cycles affect levels of blood biomarkers for Alzheimer's disease (AD) pathophysiology, ...
  • Enhancing the sensitivity of memory tests: reference data for the free and cued selective reminding test and the logical memory task from cognitively healthy subjects with normal alzheimer's disease cerebrospinal fluid biomarker levels
    Brugulat Serrat, Anna, 1986-; Cañas-Martínez, Alba; Canals-Gispert, Lidia; Marne, Paula; Gramunt Fombuena, Nina; Suárez-Calvet, Marc; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Zetterberg, Henrik; Blennow, Kaj; Gispert López, Juan Domingo; Molinuevo, José Luis; Sánchez Benavides, Gonzalo; ALFA Study (IOS Press, 2021)
    Background: Cognitive performance of a given individual should be interpreted in the context of reference standards obtained in cognitively healthy populations. Recent evidence has shown that removing asymptomatic individuals ...
  • Genotypic effects of APOE-ε4 on resting-state connectivity in cognitively intact individuals support functional brain compensation
    Cacciaglia, Raffaele; Operto, Grégory; Falcón, Carles; González de Echávarri, José Maria; Sánchez Benavides, Gonzalo; Brugulat Serrat, Anna, 1986-; Milà Alomà, Marta; Blennow, Kaj; Zetterberg, Henrik; Molinuevo, José Luis; Suárez-Calvet, Marc; Gispert López, Juan Domingo; ALFA Study (Oxford University Press, 2022)
    The investigation of resting-state functional connectivity (rsFC) in asymptomatic individuals at genetic risk for Alzheimer's disease (AD) enables discovering the earliest brain alterations in preclinical stages of the ...
  • Longitudinal associations of blood phosphorylated tau181 and neurofilament light chain with neurodegeneration in alzheimer disease
    Moscoso, Alexis; Grothe, Michel J.; Ashton, Nicholas J.; Karikari, Thomas K.; Lantero Rodriguez, Juan; Snellman, Anniina; Suárez-Calvet, Marc; Blennow, Kaj; Zetterberg, Henrik; Schöll, Michael; Alzheimer’s Disease Neuroimaging Initiative (American Medical Association, 2021)
    Importance: Plasma phosphorylated tau at threonine 181 (p-tau181) has been proposed as an easily accessible biomarker for the detection of Alzheimer disease (AD) pathology, but its ability to monitor disease progression ...
  • P-tau235: a novel biomarker for staging preclinical Alzheimer's disease
    Lantero Rodriguez, Juan; Snellman, Anniina; Benedet, Andrea L.; Milà Alomà, Marta; Camporesi, Elena; Montoliu-Gaya, Laia; Ashton, Nicholas J.; Vrillon, Agathe; Karikari, Thomas K.; Domingo Gispert, Juan; Salvadó, Gemma; Shekari, Mahnaz; Toomey, Christina E.; Lashley, Tammaryn L.; Zetterberg, Henrik; Suárez-Calvet, Marc; Brinkmalm, Gunnar; Rosa-Neto, Pedro; Blennow, Kaj (Wiley, 2021)
    Alzheimer's disease (AD) is characterised by a long preclinical phase. Although phosphorylated tau (p-tau) species such as p-tau217 and p-tau231 provide accurate detection of early pathological changes, other biomarkers ...
  • Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer's continuum
    Vilor Tejedor, Natàlia, 1988-; Ciampa, Iacopo; Operto, Grégory; Falcón, Carles; Suárez-Calvet, Marc; Crous-Bou, Marta; Shekari, Mahnaz; Arenaza Urquijo, Eider M.; Milà Alomà, Marta; Grau-Rivera, Oriol; Minguillón, Carolina; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Guigó Serra, Roderic; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (BioMed Central, 2021)
    Background: Perivascular spaces (PVS) have an important role in the elimination of metabolic waste from the brain. It has been hypothesized that the enlargement of PVS (ePVS) could be affected by pathophysiological mechanisms ...
  • Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers
    Ashton, Nicholas J.; Suárez-Calvet, Marc; Heslegrave, Amanda; Hye, Abdul; Razquin, Cristina; Pastor, Pau; Sanchez-Valle, Raquel; Molinuevo, José L.; Visser, Pieter J.; Blennow, Kaj; Hodges, Angela K.; Zetterberg, Henrik (BioMed Central, 2019)
    Background: Results from recent clinical studies suggest that cerebrospinal fluid (CSF) biomarkers that are indicative of Alzheimer's disease (AD) can be replicated in blood, e.g. amyloid-beta peptides (Aβ42 and Aβ40) and ...
  • Plasma p-tau181 accurately predicts Alzheimer's disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline
    Lantero Rodriguez, Juan; Karikari, Thomas K.; Suárez-Calvet, Marc; Troakes, Claire; King, Andrew; Emersic, Andreja; Aarsland, Dag; Hye, Abdul; Zetterberg, Henrik; Blennow, Kaj; Ashton, Nicholas J. (SpringerOpen, 2020)
    The neuropathological confirmation of amyloid-β (Aβ) plaques and tau neurofibrillary tangles (NFT) remains the gold standard for a definitive diagnosis of Alzheimer's disease (AD). Nowadays, the in vivo diagnosis of AD is ...