Browsing by Author "Zaurín Quer, Roser"

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  • Zaurín Quer, Roser; Ferrari, Roberto; Nacht, A. Silvina; Carbonell-Caballero, Jose; Le Dily, François; Font Mateu, Jofre, 1977-; De Llobet, Lara Isabel; Vidal Ocabo, Enrique; Lioutas, Antonio, 1980-; Beato, Miguel; Vincent, Guillermo P. (Oxford University Press, 2021)
    Here, we report that in T47D breast cancer cells 50 pM progestin is sufficient to activate cell cycle entry and the progesterone gene expression program. At this concentration, equivalent to the progesterone blood levels ...
  • Nacht, A. Silvina; Ferrari, Roberto; Zaurín Quer, Roser; Scabia, Valentina; Carbonell-Caballero, Jose; Le Dily, François; Quilez Oliete, Javier; Leopoldi, Alexandra; Brisken, Cathrin; Beato, Miguel; Vicent, Guillermo Pablo (EMBO Press, 2019)
    Steroid hormones are key gene regulators in breast cancer cells. While estrogens stimulate cell proliferation, progestins activate a single cell cycle followed by proliferation arrest. Here, we use biochemical and genome-wide ...
  • Nacht, A. Silvina; Pohl, Andy, 1979-; Zaurín Quer, Roser; Soronellas, Daniel; Quilez Oliete, Javier; Sharma, Priyanka; Wright, Roni H.G.; Beato, Miguel; Vincent, Guillermo P. (EMBO Press, 2016)
    Eukaryotic gene regulation is associated with changes in chromatin compaction that modulate access to DNA regulatory sequences relevant for transcriptional activation or repression. Although much is known about the mechanism ...
  • Ballaré, Cecilia Julia; Castellano, Giancarlo; Gaveglia, Laura; Althammer, Sonja Daniela; González-Vallinas Rostes, Juan, 1983-; Eyras Jiménez, Eduardo; Le Dily, François; Zaurín Quer, Roser; Soronellas, Daniel; Vicent, Guillermo Pablo; Beato, Miguel (Elsevier, 2013)
    In fission yeast cells, Cds1 is the effector kinase of the DNA replication checkpoint. We previously showed that when the DNA replication checkpoint is activated, the repressor Yox1 is phosphorylated and inactivated by ...
  • Bertucci, Paola Y.; Nacht, A. Silvina; Alló, Mariano; Rocha-Viegas, Luciana; Ballaré, Cecilia Julia; Soronellas, Daniel; Castellano, Giancarlo; Zaurín Quer, Roser; Kornblihtt, Alberto R.; Beato, Miguel; Vicent, Guillermo Pablo; Pecci, Adali (Oxford University Press, 2013)
    Steroid receptors were classically described for regulating transcription by binding to target gene promoters. However, genome-wide studies reveal that steroid receptors-binding sites are mainly located at intragenic ...
  • Bianchi, Agostina; Scherer, Michael; Zaurín Quer, Roser; Quililan, Kimberly; Velten, Lars; Beekman, Renée (BioMed Central, 2022)
    Single-cell DNA methylation profiling currently suffers from excessive noise and/or limited cellular throughput. We developed scTAM-seq, a targeted bisulfite-free method for profiling up to 650 CpGs in up to 10,000 cells ...
  • Zaurín Quer, Roser (Universitat Pompeu Fabra, 2011-04-12)
    Evidències recents han remarcat la importància del paper de l'estructura de la cromatina i el posicionament de nucleosomes en processos cel·lulars bàsics com és la regulació de la transcripció gènica. L'avenç de noves ...

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