Browsing by Author "Yélamos López, José"

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  • Acceptance of living liver donation among medical students: a multicenter stratified study from Spain
    Ríos, Antonio; Yélamos López, José; Parrilla, Pascual (Baishideng Publishing Group, 2016)
    AIM: To analyze the attitude of Spanish medical students toward living liver donation (LLD) and to establish which factors have an influence on this attitude. METHODS: STUDY TYPE: A sociological, interdisciplinary, multicenter ...
  • Adaptive NKG2C+ natural killer cells are related to exacerbations and nutritional abnormalities in COPD patients
    Pascual Guàrdia, Sergi, 1979-; Ataya Fernández, Michelle, 1993-; Ramírez Martínez, Isabel; Yélamos López, José; Chalela Rengifo, Roberto José, 1985-; Bellido, Salomé; López-Botet, Miguel; Gea Guiral, Joaquim (BioMed Central, 2020)
    Abstract: Chronic obstructive pulmonary disease (COPD) is a chronic and often progressive disorder with a heterogeneous presentation and frequent systemic manifestations. Several aspects like persistence in smoking habit, ...
  • ADP-ribosyltransferases, an update on function and nomenclature
    Lüscher, Bernhard; Yélamos López, José; Ziegler, Mathias (Wiley, 2022)
    ADP-ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad functions, including roles in stress responses elicited, for example, by DNA damage and viral infection and is involved in intra- ...
  • ATM/MAPK7 crosstalk in cancer
    Yélamos López, José (Impact Journals, 2017)
  • Basophil Activation Test identifies the patients with Chronic Spontaneous Urticaria suffering the most active disease
    Curto-Barredo, Laia; Yélamos López, José; Gimeno Martínez, Ramón; Mojal, Sergio; Pujol Vallverdú, Ramon Maria; Giménez Arnau, Anna Maria (Wiley, 2016)
    The basophil activation test showing CD63 up regulation could be a specific and sensitive in vitro complementary text to the in vivo autologous serum skin test for the activity assessment of the patients suffering autoimmune ...
  • Dual Role of Natural Killer Cells on Graft Rejection and Control of Cytomegalovirus Infection in Renal Transplantation
    López-Botet, Miguel; Vilches, Carlos; Redondo Pachón, María Dolores; Muntasell i Castellví, Aura, 1972-; Pupuleku, Aldi, 1985-; Yélamos López, José; Pascual Santos, Julio; Crespo Barrio, Marta (Frontiers, 2017)
    Allograft rejection constitutes a major complication of solid organ transplantation requiring prophylactic/therapeutic immunosuppression, which increases susceptibility of patients to infections and cancer. Beyond the ...
  • Immunomodulatory roles of PARP-1 and PARP-2: impact on PARP-centered cancer therapies
    Yélamos López, José; Lama, Lucía, 1993-; Jimeno, Jaime; Ali, Syed O. (MDPI, 2020)
    Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 are enzymes which post-translationally modify proteins through poly(ADP-ribosyl)ation (PARylation)-the transfer of ADP-ribose chains onto amino acid residues-with a resultant ...
  • Impact of cytomegalovirus infection on B cell differentiation and cytokine production in multiple sclerosis
    Zabalza, Ana; Vera, Andrea; Alari-Pahissa, Elisenda; Munteis Olivas, Elvira; Moreira Villanueva, Antía; Yélamos López, José; Llop, Mireia; López-Botet, Miguel; Martínez Rodríguez, Jose E. (BioMed Central, 2020)
    Background: Human cytomegalovirus (HCMV) infection has been recently associated with a low risk of multiple sclerosis (MS), yet the basis behind this observation remains uncertain. In this study, we aimed to determine in ...
  • Impact of DNA damage response-targeted therapies on the immune response to tumours
    Lutfi, Nura; Galindo-Campos, Miguel A.; Yélamos López, José (MDPI, 2021)
    The DNA damage response (DDR) maintains the stability of a genome faced with genotoxic insults (exogenous or endogenous), and aberrations of the DDR are a hallmark of cancer cells. These cancer-specific DDR defects present ...
  • Impact of persistent and cleared preformed HLA DSA on kidney transplant outcomes
    Redondo Pachón, María Dolores; Pérez-Sáez, María José; Mir Fontana, M. Luisa; Gimeno Beltran, Javier; Llinàs-Mallol, Laura; García, Carmen; Hernández, Juan José; Yélamos López, José; Pascual Santos, Julio; Crespo Barrio, Marta (Elsevier, 2018)
    Preformed HLA donor-specific antibodies (DSA) only detected with Luminex have been associated with increased risk of antibody-mediated rejection (ABMR) and graft failure after kidney transplantation (KT). Their evolution ...
  • Increased PARP activity and DNA damage in NSCLC patients: the influence of COPD
    Tang, Jun; Curull Serrano, Víctor; Wang, Xuejie; Ampurdanés, Coral; Duran, Xavier; Pijuan Andujar, Lara; Rodríguez-Fuster, Alberto; Aguiló Espases, Rafael; Yélamos López, José; Barreiro Portela, Esther (MDPI, 2020)
    Background: Lung cancer (LC) is a major leading cause of death worldwide. Poly (ADP-ribose) polymerase (PARP)-1 and PARP-2 are key players in cancer. We aimed to assess PARP-1 and PARP-2 expression and activity and DNA ...
  • Long-term evolution of the adaptive NKG2C + NK cell response to cytomegalovirus infection in kidney transplantation: an insight on the diversity of host-pathogen interaction
    Ataya Fernández, Michelle, 1993-; Redondo Pachón, María Dolores; Llinàs-Mallol, Laura; Yélamos López, José; Alari-Pahissa, Elisenda; Pérez-Sáez, María José; Altadill, Mireia; Raïch-Regué, Dàlia; Vilches, Carlos; Pascual Santos, Julio; Crespo Barrio, Marta; López-Botet, Miguel (American Association of Immunologists - AAI, 2021)
    Human CMV infection is frequent in kidney transplant recipients (KTR). Pretransplant Ag-specific T cells and adaptive NKG2C+ NK cells associate with reduced incidence of infection in CMV+ KTR. Expansions of adaptive NKG2C+ ...
  • Long-term redistribution of peripheral lymphocyte subpopulations after switching from calcineurin to mTOR inhibitors in kidney transplant recipients
    Llinàs-Mallol, Laura; Redondo Pachón, María Dolores; Redondo Pachón, María Dolores; Pérez-Sáez, María José; Yélamos López, José; Duran Jordà, Xavier, 1974-; Faura, Anna; López-Botet, Miguel; Pascual Santos, Julio; Crespo Barrio, Marta (MDPI, 2020)
    Classical immunosuppression based on steroids, calcineurin inhibitors, and mycophenolate results in several unwanted effects and unsatisfactory long-term outcomes in kidney transplantation (KT). New immunosuppressors search ...
  • LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells
    Cebrià i Costa, Joan Pau, 1989-; Pascual-Reguant, Laura; Gonzalez-Perez, Abel; Serra Bardenys, Gemma, 1992-; Querol, J.; Cosín, M.; Verde, Gaetano; Cigliano, Riccardo Aiese; Sanseverino, Walter; Segura-Bayona, Sandra; Iturbide Martínez de Albéniz, Ane, 1989-; Andreu Martínez, David; Nuciforo, Paolo G.; Bernado-Morales, C.; Rodilla, Verónica; Arribas, Joaquín; Yélamos López, José; García de Herreros, Antonio; Stracker, Travis; Peiró Sales, Sandra (Nature Research, 2020)
    Oxidation of H3 at lysine 4 (H3K4ox) by lysyl oxidase-like 2 (LOXL2) generates an H3 modification with an unknown physiological function. We find that LOXL2 and H3K4ox are higher in triple-negative breast cancer (TNBC) ...
  • MicroRNA expression and protein acetylation pattern in respiratory and limb muscles of Parp-1(-/-) and Parp-2(-/-) mice with lung cancer cachexia.
    Chacón-Cabrera, Alba; Fermoselle Pérez, Clara, 1985-; Salmela, Ida; Yélamos López, José; Barreiro Portela, Esther (Elsevier, 2015)
    BACKGROUND: Current treatment options for cachexia, which impairs disease prognosis, are limited. Muscle-enriched microRNAs and protein acetylation are involved in muscle wasting including lung cancer (LC) cachexia. ...
  • PARP-1 is critical for recruitment of dendritic cells to the lung in a mouse model of asthma but dispensable for their differentiation and function
    Echeverri Tirado, Laura C.; Ghonim, Mohamed A.; Wang, Jeffrey; Al-Khami, Amir A.; Wyczechowska, Dorota; Luu, Hanh H.; Hogyoung, Kim; Sanchez-Pino, Maria Dulfary; Yélamos López, José; Yassin, Lina M.; Boulares, A. Hamid (Hindawi, 2019)
    Dendritic cells (DCs) are critical in asthma and many other immune diseases. We previously demonstrated a role for PARP-1 in asthma. Evidence on PARP-1 playing a role in Th2-associated DC function is not clear. In this ...
  • PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas
    Navarro, Judith; Gozalbo-López, Beatriz; Méndez, Andrea C.; Dantzer, Françoise; Schreiber, Valérie; Martínez, Carlos; Arana, David M.; Farrés, Jordi; Revilla-Nuin, Beatriz; Bueno, María F.; Ampurdanés, Coral; Galindo-Campos, Miguel A.; Knobel, Philip A.; Segura-Bayona, Sandra; Martin-Caballero, Juan; Stracker, Travis; Aparicio, Pedro; Del Val, Margarita; Yélamos López, José (Nature Publishing Group, 2017)
    The maintenance of T-cell homeostasis must be tightly regulated. Here, we have identified a coordinated role of Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 in maintaining T-lymphocyte number and function. Mice bearing ...
  • Peripheral blood lymphocyte subsets change after steroid withdrawal in renal allograft recipients: a prospective study
    Llinàs-Mallol, Laura; Redondo Pachón, María Dolores; Pérez-Sáez, María José; Raïch-Regué, Dàlia; Mir, Marisa; Yélamos López, José; López-Botet, Miguel; Pascual Santos, Julio; Crespo Barrio, Marta (Nature Research, 2019)
    Several studies have assessed clinical outcomes after steroid withdrawal (SW) in kidney transplant (KT) recipients, but little is known about its potential impact on lymphocyte subpopulations. We designed a prospective ...
  • Poly(ADP-Ribose) Polymerases: New Players in the Pathogenesis of Exocrine Pancreatic Diseases.
    Martínez Bosch, Neus; Fernández-Zapico, Martin E.; Navarro Medrano, Pilar; Yélamos López, José (Elsevier, 2016)
    The poly(ADP-ribose) polymerase (PARP) enzymes were initially characterized as sensors of DNA breaks but are now known to play key roles not only in the DNA damage response but also in regulating numerous molecular processes, ...
  • Pretransplant adaptive NKG2C+ NK cells protect against cytomegalovirus infection in kidney transplant recipients
    Ataya Fernández, Michelle, 1993-; Redondo Pachón, María Dolores; Llinàs-Mallol, Laura; Yélamos López, José; Heredia, Gemma; Pérez-Sáez, María José; Vila, Joan; Costa García, Marcel, 1989-; Raïch-Regué, Dàlia; Vilches, Carlos; Pascual, Julio (Pascual Santos); Crespo Barrio, Marta; López-Botet, Miguel (Wiley-Blackwell, 2019)
    Cytomegalovirus (CMV) infection constitutes a complication for kidney transplant recipients (KTR) and CMV-specific T cells reduce the risk of viral replication in seropositive patients. CMV promotes the adaptive differentiation ...