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Browsing by Author "Wyatt, Christopher Douglas Robert, 1988-"

Browsing by Author "Wyatt, Christopher Douglas Robert, 1988-"

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  • A developmentally programmed splicing failure contributes to DNA damage response attenuation during mammalian zygotic genome activation
    Wyatt, Christopher Douglas Robert, 1988-; Pernaute, Barbara; Gohr, André; Miret-Cuesta, Marta; Goyeneche, Lucia; Rovira, Quirze; Salzer, Marion C.; Boke, Elvan; Bogdanovic, Ozren; Bonnal, Sophie; Irimia Martínez, Manuel (American Association for the Advancement of Science (AAAS), 2022)
    Transition from maternal to embryonic transcriptional control is crucial for embryogenesis. However, alternative splicing regulation during this process remains understudied. Using transcriptomic data from human, mouse, ...
  • Alternative splicing changes promoted by NOVA2 upregulation in endothelial cells and relevance for gastric cancer
    Di Matteo, Anna; Belloni, Elisa; Pradella, Davide; Chiaravalli, Anna Maria; Pini, Giacomo Maria; Bugatti, Mattia; Alfieri, Roberta; Barzan, Chiara; Franganillo Tena, Elena; Bione, Silvia; Terenzani, Elisa; Sessa, Fausto; Wyatt, Christopher Douglas Robert, 1988-; Vermi, William; Ghigna, Claudia (MDPI, 2023)
    Angiogenesis is crucial for cancer progression. While several anti-angiogenic drugs are in use for cancer treatment, their clinical benefits are unsatisfactory. Thus, a deeper understanding of the mechanisms sustaining ...
  • The alternative splicing factor Nova2 regulates vascular development and lumen formation
    Giampietro, Costanza; Wyatt, Christopher Douglas Robert, 1988-; Irimia Martínez, Manuel; Ghigna, Claudia (Nature Publishing Group, 2015)
    Vascular lumen formation is a fundamental step during angiogenesis; yet, the molecular mechanisms underlying this process are poorly understood. Recent studies have shown that neural and vascular systems share common ...
  • Amphioxus functional genomics and the origins of vertebrate gene regulation
    Marlétaz, Ferdinand; Wyatt, Christopher Douglas Robert, 1988-; Burguera, Demián; Marquez, Yamile; Irimia Martínez, Manuel (Nature Research, 2018)
    Vertebrates have greatly elaborated the basic chordate body plan and evolved highly distinctive genomes that have been sculpted by two whole-genome duplications. Here we sequence the genome of the Mediterranean amphioxus ...
  • Cooperative epithelial phagocytosis enables error correction in the early embryo
    Hoijman, Esteban; Häkkinen, Hanna-Maria; Tolosa-Ramon, Queralt; Jiménez-Delgado, Senda; Wyatt, Christopher Douglas Robert, 1988-; Miret-Cuesta, Marta; Irimia Martínez, Manuel; Callan-Jones, Andrew; Wieser, Stefan; Ruprecht, Verena (Nature Research, 2021)
    Errors in early embryogenesis are a cause of sporadic cell death and developmental failure1,2. Phagocytic activity has a central role in scavenging apoptotic cells in differentiated tissues3-6. However, how apoptotic cells ...
  • Evolutionary origin and functional divergence of totipotent cell homeobox genes in eutherian mammals
    Maeso, Ignacio; Dunwell, Thomas L.; Wyatt, Christopher Douglas Robert, 1988-; Marlétaz, Ferdinand; Vető, Borbála; Bernal, Juan A.; Quah, Shan; Irimia Martínez, Manuel; Holland, Peter W. H. (BioMed Central, 2016)
    BACKGROUND: A central goal of evolutionary biology is to link genomic change to phenotypic evolution. The origin of new transcription factors is a special case of genomic evolution since it brings opportunities for novel ...
  • Gene expression profiles controlled by the alternative splicing factor nova2 in endothelial cells
    Belloni, Elisa; Di Matteo, Anna; Pradella, Davide; Vacca, Margherita; Wyatt, Christopher Douglas Robert, 1988-; Alfieri, Roberta; Maffia, Antonio; Sabbioneda, Simone; Ghigna, Claudia (MDPI, 2019)
    Alternative splicing (AS) plays an important role in expanding the complexity of the human genome through the production of specialized proteins regulating organ development and physiological functions, as well as contributing ...
  • Genomic adaptations to aquatic and aerial life in mayflies and the origin of insect wings
    Almudi, Isabel; Wyatt, Christopher Douglas Robert, 1988-; Cruz, Fernando; Gómez-Garrido, Jèssica; Gut, Marta; Alioto, Tyler; Irimia Martínez, Manuel; Casares, Fernando (Nature Research, 2020)
    The evolution of winged insects revolutionized terrestrial ecosystems and led to the largest animal radiation on Earth. However, we still have an incomplete picture of the genomic changes that underlay this diversification. ...
  • Molecular signatures of plastic phenotypes in two eusocial insect species with simple societies
    Solenn, Patalano; Vlasova, Anna; Wyatt, Christopher Douglas Robert, 1988-; Cámara, Francisco; Pedro G., Ferreira; González, Irene; Minoche, André E.; Lowy Gallego, Ernesto; Marcet Houben, Marina; Rodríguez Ales, José Luis; Gabaldón Estevan, Juan Antonio, 1973-; Himmelbauer, Heinz; Guigó Serra, Roderic; Sumner, Seirian (National Academy of Sciences, 2015)
    Phenotypic plasticity is important in adaptation and shapes the evolution of organisms. However, we understand little about what aspects of the genome are important in facilitating plasticity. Eusocial insect societies ...
  • Putting hornets on the genomic map
    Favreau, Emeline; Cini, Alessandro; Taylor, Daisy; Câmara Ferreira, Francisco; Bentley, Michael A.; Cappa, Federico; Cervo, Rita; Privman, Eyal; Schneider, Jadesada; Thiéry, Denis; Mashoodh, Rahia; Wyatt, Christopher Douglas Robert, 1988-; Brown, Robert L.; Bodrug-Schepers, Alexandrina; Stralis-Pavese, Nancy; Dohm, Juliane C.; Mead, Daniel; Himmelbauer, Heinz; Guigó Serra, Roderic; Sumner, Seirian (Nature Research, 2023)
    Hornets are the largest of the social wasps, and are important regulators of insect populations in their native ranges. Hornets are also very successful as invasive species, with often devastating economic, ecological and ...
  • The trophectoderm acts as a niche for the inner cell mass through C/EBPα-regulated IL-6 signaling
    Plana-Carmona, Marcos; Stik, Grégoire; Bulteau, Romain; Segura-Morales, Carolina; Alcázar, Noelia; Wyatt, Christopher Douglas Robert, 1988-; Klonizakis, Antonios; Andrés Aguayo, Luisa de; Gasnier, Maxime; Tian, Tian V.; Torcal Garcia, Guillem, 1991-; Vila-Casadesús, Maria; Plachta, Nicolas; Serrano, Manuel; Francesconi, Mirko; Graf, T. (Thomas) (Elsevier, 2022)
    IL-6 has been shown to be required for somatic cell reprogramming into induced pluripotent stem cells (iPSCs). However, how Il6 expression is regulated and whether it plays a role during embryo development remains unknown. ...

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