Browsing by Author "Wotton, Karl R."

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  • Verd Fernández, Berta, 1984-; Clark, Erik; Wotton, Karl R.; Janssens, Hilde; Jiménez Guri, Eva; Crombach, Anton; Jaeger, Johannes, 1973- (Public Library of Science (PLoS), 2018)
    Insects determine their body segments in two different ways. Short-germband insects, such as the flour beetle Tribolium castaneum, use a molecular clock to establish segments sequentially. In contrast, long-germband insects, ...
  • Jiménez Guri, Eva; Wotton, Karl R.; Gavilán, Brenda; Jaeger, Johannes, 1973- (Public Library of Science (PLoS), 2014)
    Model organisms, such as Drosophila melanogaster, allow us to address a wide range of biological questions with experimental rigour. However, studies in model species need to be complemented by comparative studies if we ...
  • Jiménez Guri, Eva; Huerta Cepas, Jaime; Cozzuto, Luca; Wotton, Karl R.; Kang, Hui; Himmelbauer, Heinz; Roma, Guglielmo; Gabaldón Estevan, Juan Antonio, 1973-; Jaeger, Johannes, 1973- (BioMed Central, 2013)
    BACKGROUND: Modern sequencing technologies have massively increased the amount of data available for comparative genomics. Whole-transcriptome shotgun sequencing (RNA-seq) provides a powerful basis for comparative studies. ...
  • Crombach, Anton; Wotton, Karl R.; Jiménez Guri, Eva; Jaeger, Johannes, 1973- (Oxford University Press, 2016)
    Developmental gene networks implement the dynamic regulatory mechanisms that pattern and shape the organism. Over evolutionary time, the wiring of these networks changes, yet the patterning outcome is often preserved, a ...
  • Doyle, Toby; Jiménez Guri, Eva; Hawkes, Will L.S.; Massy, Richard; Mantica, Federica; Permanyer, Jon; Cozzuto, Luca; Hermoso Pulido, Antonio; Baril, Tobias; Hayward, Alexander; Irimia Martínez, Manuel; Chapman, Jason W.; Bass, Chris; Wotton, Karl R. (Wiley, 2022)
    Insects are capable of extraordinary feats of long-distance movement that have profound impacts on the function of terrestrial ecosystems. The ability to undertake these movements arose multiple times through the evolution ...
  • Wotton, Karl R.; Jiménez Guri, Eva; Crombach, Anton; Cicin Sain, Damjan; Jaeger, Johannes, 1973- (Nature Publishing Group, 2015)
    Gap genes are involved in segment determination during early development in dipteran insects (flies, midges, and mosquitoes). We carried out a systematic quantitative comparative analysis of the gap gene network across ...
  • Janssens, Hilde; Crombach, Anton; Wotton, Karl R.; Cicin Sain, Damjan; Surkova, Svetlana; Lim, Chea Lu; Samsonova, Maria; Akam, Michael; Jaeger, Johannes, 1973- (Elsevier, 2013)
    Developmental processes are robust, or canalised: dynamic patterns of gene expression across space and time are regulated reliably and precisely in the presence of genetic and environmental perturbations. It remains unclear ...
  • Wotton, Karl R.; Jiménez Guri, Eva; Jaeger, Johannes, 1973- (Public Library of Science (PLoS), 2015)
    Axis specification and segment determination in dipteran insects are an excellent model system for comparative analyses of gene network evolution. Antero-posterior polarity of the embryo is established through systems of ...
  • Alcaine Colet, Anna, 1992-; Wotton, Karl R.; Jiménez Guri, Eva (PeerJ Inc., 2015)
    Megaselia scalaris (Loew, 1866) (Diptera, phoridae) is a cosmopolitan fly species used in forensic science, and has been developed as a laboratory model species. They feed on decaying corpses as well as a wide variety of ...
  • Cicin Sain, Damjan; Hermoso Pulido, Antonio; Crombach, Anton; Wotton, Karl R.; Jiménez Guri, Eva; Taly, Jean-François; Roma, Guglielmo; Jaeger, Johannes, 1973- (Oxford University Press, 2015)
    We present SuperFly (http://superfly.crg.eu), a relational database for quantified spatio-temporal expression data of segmentation genes during early development in different species of dipteran insects (flies, midges and ...
  • Jiménez Guri, Eva; Wotton, Karl R.; Jaeger, Johannes, 1973- (Royal Society, 2018)
    Gap genes are involved in segment determination during early development of the vinegar fly Drosophila melanogaster and other dipteran insects (flies, midges and mosquitoes). They are expressed in overlapping domains along ...

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