Browsing by Author "Wang, Xuejie"

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  • B cells and tertiary lymphoid structures influence survival in lung cancer patients with resectable tumors
    Tang, Jun; Ramis Cabrer, Daniel, 1993-; Curull Serrano, Víctor; Wang, Xuejie; Mateu Jiménez, Mercè, 1990-; Pijuan Andujar, Lara; Duran, Xavier; Qin, Liyun; Rodríguez-Fuster, Alberto; Aguiló Espases, Rafael; Barreiro Portela, Esther (MDPI, 2020)
    Immune profile of B and T cells and tertiary lymphoid structures (TLSs) may differ in tumors of lung cancer (LC) patients with/without chronic obstructive pulmonary disease (COPD), and may also influence patient survival. ...
  • Blood neutrophil counts define specific clusters of bronchiectasis patients: A hint to differential clinical phenotypes
    Wang, Xuejie; Olveira, Casilda; Girón, Rosa; García-Clemente, Marta; Máiz, Luis; Sibila, Oriol; Golpe, Rafael; Menéndez, Rosario; Rodríguez-López, Juan; Prados, Concepción; Martínez-González, Miguel A.; Rodriguez, Juan Luis; Rosa, David de la; Qin, Liyun; Duran Jordà, Xavier, 1974-; García Ojalvo, Jordi; Barreiro Portela, Esther (MDPI, 2022)
    We sought to investigate differential phenotypic characteristics according to neutrophil counts, using a biostatistics approach in a large-cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 1034 ...
  • COPD: preclinical models and emerging therapeutic targets
    Barreiro Portela, Esther; Wang, Xuejie; Tang, Jun (Informa Healthcare, 2019)
    Introduction: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Preclinical models of COPD have recently been developed. In those models, COPD/emphysema has been commonly ...
  • Differences in nutritional status and inflammatory biomarkers between female and male patients with bronchiectasis: a large-cohort study
    Wang, Xuejie; Villa, Carmen; Dobarganes, Yadira; Olveira, Casilda; Girón, Rosa; García-Clemente, Marta; Máiz, Luis; Sibila, Oriol; Golpe, Rafael; Menéndez, Rosario; Rodríguez-López, Juan; Prados, Concepción; Martínez-García, Miguel Ángel; Rodriguez, Juan Luis; Rosa, David de la; Duran, Xavier; Barreiro Portela, Esther (MDPI, 2021)
    We hypothesized that systemic inflammatory and nutritional parameters may differ between male and female patients with non-CF bronchiectasis. In a large patient cohort from the Spanish Online Bronchiectasis Registry (RIBRON), ...
  • Do redox balance and inflammatory events take place in mild bronchiectasis? a hint to clinical implications
    Qin, Liyun; Guitart, Maria; Admetlló Papiol, Mireia; Esteban-Cucó, Sandra; Maiques LLacer, José María; Xia, Yingchen; Zha, Jianhua; Carbullanca Toledo, Santiago; Duran, Xavier; Wang, Xuejie; Barreiro Portela, Esther (MDPI, 2021)
    We hypothesized that in mild bronchiectasis patients, increased systemic inflammation and redox imbalance may take place and correlate with clinical parameters. In plasma samples from patients with very mild bronchiectasis, ...
  • Immune cell subtypes and cytokines in lung tumor microenvironment: influence of COPD
    Tang, Jun; Ramis Cabrer, Daniel, 1993-; Curull Serrano, Víctor; Wang, Xuejie; Qin, Liyun; Mateu Jiménez, Mercè, 1990-; Duran Jordà, Xavier, 1974-; Pijuan Andujar, Lara; Rodríguez-Fuster, Alberto; Aguiló Espases, Rafael; Barreiro Portela, Esther (MDPI, 2020)
    Background: The immune microenvironment plays a role in tumorigenesis. Chronic Obstructive Pulmonary Disease (COPD) is an independent risk factor for lung cancer (LC). We hypothesized that immune profile characterized by ...
  • Immunotherapy with monoclonal antibodies in lung cancer of mice: oxidative stress and other biological events
    Tang, Jun; Ramis Cabrer, Daniel, 1993-; Wang, Xuejie; Barreiro Portela, Esther (MDPI, 2019)
    Background: Lung cancer (LC) is a major leading cause of death worldwide. Immunomodulators that target several immune mechanisms have proven to reduce tumor burden in experimental models through induction of the immune ...
  • Increased PARP activity and DNA damage in NSCLC patients: the influence of COPD
    Tang, Jun; Curull Serrano, Víctor; Wang, Xuejie; Ampurdanés, Coral; Duran, Xavier; Pijuan Andujar, Lara; Rodríguez-Fuster, Alberto; Aguiló Espases, Rafael; Yélamos López, José; Barreiro Portela, Esther (MDPI, 2020)
    Background: Lung cancer (LC) is a major leading cause of death worldwide. Poly (ADP-ribose) polymerase (PARP)-1 and PARP-2 are key players in cancer. We aimed to assess PARP-1 and PARP-2 expression and activity and DNA ...
  • Phenotypic clustering in non-cystic fibrosis bronchiectasis patients: the role of eosinophils in disease severity
    Wang, Xuejie; Villa, Carmen; Dobarganes, Yadira; Olveira, Casilda; Girón, Rosa; García-Clemente, Marta; Máiz, Luis; Sibila, Oriol; Golpe, Rafael; Menéndez, Rosario; Rodríguez-López, Juan; Prados, Concepción; Martínez-García, Miguel Ángel; Rodriguez, Juan Luis; Rosa, David de la; Duran, Xavier; García Ojalvo, Jordi; Barreiro Portela, Esther (MDPI, 2021)
    Whether high blood eosinophil counts may define a better phenotype in bronchiectasis patients, as shown in chronic obstructive pulmonary disease (COPD), remains to be investigated. Differential phenotypic characteristics ...
  • Respiratory and peripheral muscle weakness and body composition abnormalities in non-cystic fibrosis bronchiectasis patients: Gender differences
    Wang, Xuejie; Balañá Corberó, Ana, 1981-; Martínez-Llorens, Juana Mª; Qin, Liyun; Xia, Yingchen; Zha, Jianhua; Maiques LLacer, José María; Barreiro Portela, Esther (MDPI, 2022)
    As demonstrated in COPD, bronchiectasis patients may experience respiratory and peripheral muscle dysfunction. We hypothesized that respiratory and peripheral (upper and lower limbs) muscle function and nutritional status ...
  • Systemic inflammatory biomarkers define specific clusters in patients with bronchiectasis: A large-cohort study
    Wang, Xuejie; Villa, Carmen; Dobarganes, Yadira; Olveira, Casilda; Girón, Rosa; García-Clemente, Marta; Máiz, Luis; Sibila, Oriol; Golpe, Rafael; Menéndez, Rosario; Rodríguez-López, Juan; Prados, Concepción; Martínez-García, Miguel Ángel; Rodriguez, Juan Luis; Rosa, David de la; Duran Jordà, Xavier, 1974-; García Ojalvo, Jordi; Barreiro Portela, Esther (MDPI, 2022)
    Differential phenotypic characteristics using data mining approaches were defined in a large cohort of patients from the Spanish Online Bronchiectasis Registry (RIBRON). Three differential phenotypic clusters (hierarchical ...