Browsing by Author "Vineis, Paolo"

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  • A multivariate approach to investigate the combined biological effects of multiple exposures
    Jain, Pooja; Vineis, Paolo; Liquet, Benoît; Vlaanderen, Jelle; Bodinier, Barbara; van Veldhoven, Karin; Kogevinas, Manolis; Athersuch, Toby J.; Font-Ribera, Laia; Villanueva Belmonte, Cristina; Vermeulen, Roel; Chadeau-Hyam, Marc (BMJ Publishing Group, 2018)
    Epidemiological studies provide evidence that environmental exposures may affect health through complex mixtures. Formal investigation of the effect of exposure mixtures is usually achieved by modelling interactions, which ...
  • A systematic comparison of statistical methods to detect interactions in exposome-health associations
    Barrera Gómez, Jose; Agier, Lydiane; Portengen, Lützen; Chadeau-Hyam, Marc; Giorgis-Allemand, Lise; Siroux, Valérie; Robinson, Oliver; Vlaanderen, Jelle; González, Juan Ramón; Nieuwenhuijsen, Mark J.; Vineis, Paolo; Vrijheid, Martine; Vermeulen, Roel; Slama, Rémy; Basagaña Flores, Xavier (BioMed Central, 2017)
    There is growing interest in examining the simultaneous effects of multiple exposures and, more generally, the effects of mixtures of exposures, as part of the exposome concept (being defined as the totality of human ...
  • Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth
    Alfano, Rossella; Zugna, Daniela; Barros, Henrique; Bustamante Pineda, Mariona; Chatzi, Leda; Ghantous, Akram; Herceg, Zdenko; Keski-Rahkonen, Pekka; Kok, Theo M. de; Nawrot, Tim S.; Relton, Caroline L.; Robinson, Oliver; Roumeliotaki, Theano; Scalbert, Augustin; Vrijheid, Martine; Vineis, Paolo; Richiardi, Lorenzo; Plusquin, Michelle (BioMed Central, 2023)
    Rapid postnatal growth may result from exposure in utero or early life to adverse conditions and has been associated with diseases later in life and, in particular, with childhood obesity. DNA methylation, interfacing ...
  • Cord blood metabolic signatures predictive of childhood overweight and rapid growth
    Handakas, Evangelos; Keski-Rahkonen, Pekka; Chatzi, Leda; Alfano, Rossella; Roumeliotaki, Theano; Plusquin, Michelle; Maitre, Léa; Richiardi, Lorenzo; Brescianini, Sonia; Scalbert, Augustin; Robinot, Nivonirina; Nawrot, Tim S.; Sassi, Franco; Vrijheid, Martine; Vineis, Paolo; Robinson, Oliver (Nature Research, 2021)
    Introduction: Metabolomics may identify biological pathways predisposing children to the risk of overweight and obesity. In this study, we have investigated the cord blood metabolic signatures of rapid growth in infancy ...
  • Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight
    Alfano, Rossella; Plusquin, Michelle; Robinson, Oliver; Brescianini, Sonia; Chatzi, Leda; Keski-Rahkonen, Pekka; Handakas, Evangelos; Maitre, Léa; Nawrot, Tim S.; Robinot, Nivonirina; Roumeliotaki, Theano; Sassi, Franco; Scalbert, Augustin; Vrijheid, Martine; Vineis, Paolo; Richiardi, Lorenzo; Zugna, Daniela (Nature Research, 2022)
    Background: The mechanisms underlying childhood overweight and obesity are poorly known. Here, we investigated the direct and indirect effects of different prenatal exposures on offspring rapid postnatal growth and overweight ...
  • DNA methylation in inflammatory pathways modifies the association between BMI and adult-onset non-atopic asthma
    Jeong, Ayoung; Imboden, Medea; Ghantous, Akram; Novoloaca, Alexei; Carsin, Anne-Elie; Kogevinas, Manolis; Schindler, Christian; Lovison, Gianfranco; Herceg, Zdenko; Cuenin, Cyrille; Vermeulen, Roel; Jarvis, Deborah; Amaral, André F.S.; Kronenberg, Florian; Vineis, Paolo; Probst-Hensch, Nicole (MDPI, 2019)
    A high body mass (BMI) index has repeatedly been associated with non-atopic asthma, but the biological mechanism linking obesity to asthma is still poorly understood. We aimed to test the hypothesis that inflammation and/or ...
  • DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia
    Georgiadis, Panagiotis; Gavriil, Marios; Rantakokko, Panu; Ladoukakis, Efthymios; Botsivali, Maria; Kelly, Rachel S.; Bergdahl, Ingvar A.; Kiviranta, Hannu; Vermeulen, Roel; Spaeth, Florentin; Hebbels, Dennie G. A. J.; Kleinjans, Jos C.; Kok, Theo M. de; Palli, Domenico; Vineis, Paolo; Kyrtopoulos, Sosterios A.; EnviroGenomarkers consortium (Elsevier, 2019)
    Objectives: To characterize the impact of PCB exposure on DNA methylation in peripheral blood leucocytes and to evaluate the corresponding changes in relation to possible health effects, with a focus on B-cell lymphoma. ...
  • ExpoApp: an integrated system to assess multiple personal environmental exposures
    Donaire González, David; Valentín, Antònia; van Nunen, Erik; Curto Tirado, Ariadna, 1987-; Rodriguez, Albert; Fernandez-Nieto, Mario; Naccarati, Alessio; Tarallo, Sonia; Tsai, Ming-Yi; Probst-Hensch, Nicole; Vermeulen, Roel; Hoek, Gerard; Vineis, Paolo; Gulliver, John; Nieuwenhuijsen, Mark J. (Elsevier, 2019)
    To assess environmental exposures at the individual level, new assessment methods and tools are required. We developed an exposure assessment system (ExpoApp) for smartphones. ExpoApp integrates: (i) geo-location and ...
  • Exposure to disinfection by-products in swimming pools and biomarkers of genotoxicity and respiratory damage - The PISCINA2 Study
    Font-Ribera, Laia; Barreiro Portela, Esther; Gracia Lavedan, Esther; Arjona, Lourdes; De Bont, Jeroen, 1989-; Tarès, Lluïsa; Vineis, Paolo; Kogevinas, Manolis; Villanueva Belmonte, Cristina (Elsevier, 2019)
    BACKGROUND: Swimming in pools is a healthy activity that entails exposure to disinfection by-products (DBPs), some of which are irritant and genotoxic. OBJECTIVES: We evaluated exposure to DBPs during swimming in a chlorinated ...
  • Exposure to widespread drinking water chemicals, blood inflammation markers, and colorectal cancer
    Villanueva, Cristina M.; Espinosa Díaz, Ana; Gracia-Lavedan, Esther; Vlaanderen, Jelle; Vermeulen, Roel; Molina, Antonio J.; Amiano, Pilar; Gómez-Acebo, Inés; Castaño Vinyals, Gemma; Vineis, Paolo; Kogevinas, Manolis (Elsevier, 2021)
    Background: Trihalomethanes (THMs) and nitrate are widespread chemicals in drinking water associated with colorectal cancer risk but mechanisms are not well understood. Objectives: We explored the association between ...
  • Impact of short-term traffic-related air pollution on the metabolome - Results from two metabolome-wide experimental studies
    van Veldhoven, Karin; Kiss, Agneta; Keski-Rahkonen, Pekka; Robinot, Nivonirina; Scalbert, Augustin; Cullinan, Paul; Chung, Kian Fan; Collins, Peter; Sinharay, Rudy; Barratt, Benjamin M.; Nieuwenhuijsen, Mark J.; Ambros, Albert; Carrasco Turigas, Glòria; Vlaanderen, Jelle; Vermeulen, Roel; Portengen, Lützen; Kyrtopoulos, Sosterios A.; Ponzi, Erica; Chadeau-Hyam, Marc; Vineis, Paolo (Elsevier, 2019)
    Exposure to traffic-related air pollution (TRAP) has been associated with adverse health outcomes but underlying biological mechanisms remain poorly understood. Two randomized crossover trials were used here, the Oxford ...
  • Plasma concentrations of persistent organic pollutants and pancreatic cancer risk
    Porta Serra, Miquel; Gasull Panadès, Magda; Pumarega Rodríguez, José Antonio; Giménez-Robert, Àlex; Vineis, Paolo (Oxford University Press, 2022)
    Background: Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts. Methods: We conducted a prospective ...
  • Short-term exposure to traffic-related air pollution reveals a compound-specific circulating miRNA profile indicating multiple disease risks
    Krauskopf, Julian; van Veldhoven, Karin; Chadeau-Hyam, Marc; Vermeulen, Roel; Carrasco Turigas, Glòria; Nieuwenhuijsen, Mark J.; Vineis, Paolo; Kok, Theo M. de; Kleinjans, Jos C. (Elsevier, 2019)
    Traffic-related air pollution (TRAP) is a complex mixture of compounds that contributes to the pathogenesis of many diseases including several types of cancer, pulmonary, cardiovascular and neurodegenerative diseases, and ...
  • The relationship between air pollution and multimorbidity: Can two birds be killed with the same stone?
    Arias-de la Torre, Jorge; Ronaldson, Amy; Alonso Caballero, Jordi; Dregan, Alex; Mudway, Ian; Valderas Martínez, José María; Vineis, Paolo; Bakolis, Ioannis (Springer, 2023)
    Air pollution and multimorbidity are two of the most important challenges for Public Health worldwide. Although there is a large body of evidence linking air pollution with the development of different single chronic ...