Browsing by Author "Vila-Casadesús, Maria"

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  • Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity
    Torcal Garcia, Guillem, 1991-; Kowenz-Leutz, Elisabeth; Tian, Tian V.; Klonizakis, Antonios; Lerner, Jonathan; Andrés Aguayo, Luisa de; Sapozhnikova, Valeriia; Berenguer, Clara; Plana Carmona, Marcos, 1993-; Vila-Casadesús, Maria; Bulteau, Romain; Francesconi, Mirko; Peiró Sales, Sandra; Mertins, Philipp; Zaret, Kenneth S.; Leutz, Achim; Graf, T. (Thomas) (eLife, 2023)
    Here, we describe how the speed of C/EBPα-induced B cell to macrophage transdifferentiation (BMT) can be regulated, using both mouse and human models. The identification of a mutant of C/EBPα (C/EBPαR35A) that greatly ...
  • CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response
    Stik, Grégoire; Vidal, Enrique; Barrero, Mercedes; Cuartero, Sergi; Vila-Casadesús, Maria; Mendieta Esteban, Julen, 1992-; Tian, Tian V.; Choi, Jinmi; Berenguer, Clara; Abad, Amaya; Borsari, Beatrice, 1992-; Le Dily, François; Cramer, Patrick; Martí Renom, Marc A.; Stadhouders, Ralph; Graf, T. (Thomas) (Nature Research, 2020)
    Three-dimensional organization of the genome is important for transcriptional regulation1-7. In mammals, CTCF and the cohesin complex create submegabase structures with elevated internal chromatin contact frequencies, ...
  • Genome-wide miR-155 and miR-802 target gene identification in the hippocampus of Ts65Dn Down syndrome mouse model by miRNA sponges
    Bofill-De Ros, Xavier; Santos, Mónica; Vila-Casadesús, Maria; Villanueva, Eneko; Andreu Somavilla, Núria; Dierssen, Mara; Fillat i Fonts, Cristina (BioMed Central, 2015)
    Background. Down syndrome (DS) or trisomy 21 is the result of a genetic dosage imbalance that translates in a broad clinical spectrum. A major challenge in the study of DS is the identification of functional genetic elements ...
  • Mutational Signatures in Cancer (MuSiCa): a web application to implement mutational signatures analysis in cancer samples
    Díaz-Gay, Marcos; Vila-Casadesús, Maria; Franch-Expósito, Sebastià; Hernández-Illán, Eva; Lozano, Juan José; Castellví Bel, Sergi (BioMed Central, 2018)
    Background: Mutational signatures have been proved as a valuable pattern in somatic genomics, mainly regarding cancer, with a potential application as a biomarker in clinical practice. Up to now, several bioinformatic ...
  • The trophectoderm acts as a niche for the inner cell mass through C/EBPα-regulated IL-6 signaling
    Plana-Carmona, Marcos; Stik, Grégoire; Bulteau, Romain; Segura-Morales, Carolina; Alcázar, Noelia; Wyatt, Christopher Douglas Robert, 1988-; Klonizakis, Antonios; Andrés Aguayo, Luisa de; Gasnier, Maxime; Tian, Tian V.; Torcal Garcia, Guillem, 1991-; Vila-Casadesús, Maria; Plachta, Nicolas; Serrano, Manuel; Francesconi, Mirko; Graf, T. (Thomas) (Elsevier, 2022)
    IL-6 has been shown to be required for somatic cell reprogramming into induced pluripotent stem cells (iPSCs). However, how Il6 expression is regulated and whether it plays a role during embryo development remains unknown. ...
  • Whsc1 links pluripotency exit with mesendoderm specification
    Tian, Tian V.; Di Stefano, Bruno, 1984-; Stik, Grégoire; Vila-Casadesús, Maria; Sardina, Jose Luis; Vidal Ocabo, Enrique; Dasti, Alessandro, 1988-; Segura-Morales, Carolina; de Andrés-Aguayo, Luisa; Gómez, Antonio; Goldmann, Johanna; Jaenisch, Rudolf; Graf, T. (Thomas) (Nature Research, 2019)
    How pluripotent stem cells differentiate into the main germ layers is a key question of developmental biology. Here, we show that the chromatin-related factor Whsc1 (also known as Nsd2 and MMSET) has a dual role in ...

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