Browsing by Author "Varela, Ignacio"

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  • Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions
    Bueno, Clara; Calero-Nieto, Fernando J.; Wang, Xiaonan; Valdés-Mas, Rafael; Gutiérrez-Agüera, Francisco; Roca-Ho, Heleia; Ayllon, Verónica; Real, Pedro J.; Arambilet, David; Espinosa Blay, Lluís; Torres-Ruiz, Raul; Agraz-Doblas, Antonio; Varela, Ignacio; de Boer, Jasper; Bigas Salvans, Anna; Gottgens, Bertie; Marschalek, Rolf; Menéndez, Pablo (Ferrata Storti Foundation, 2019)
    The t(4;11)(q21;q23) translocation is associated with high-risk infant pro-B-cell acute lymphoblastic leukemia and arises prenatally during embryonic/fetal hematopoiesis. The developmental/pathogenic contribution of the ...
  • PLCγ1/PKCθ downstream signaling controls cutaneous T-cell lymphoma development and progression
    García-Díaz, Nuria; Casar, Berta; Alonso Alonso, Ruth; Quevedo, Laura; Rodríguez, Marta; Ruso-Julve, Fulgencio; Esteve-Codina, Anna; Gut, Marta; Gru, Alejandro A.; González Vela, María del Carmen; Gut, Ivo Glynne; Rodriguez-Peralto, José Luis; Varela, Ignacio; Ortiz-Romero, Pablo L.; Piris, Miguel A.; Vaqué, José Pedro (Elsevier, 2022)
    Developing mechanistic rationales can improve the clinical management of cutaneous T-cell lymphomas. There is considerable genetic and biological evidence of a malignant network of signaling mechanisms, highly influenced ...
  • Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis
    Agraz-Doblas, Antonio; Bueno, Clara; Bashford-Rogers, Rachael; Roy, Anindita; Schneider, Pauline; Bardini, Michela; Ballerini, Paola; Cazzaniga, Gianni; Moreno, Thaidy; Revilla, Carlos; Gut, Marta; Valsecchi, Maria G.; Roberts, Irene; Pieters, Rob; De Lorenzo, Paola; Varela, Ignacio; Menéndez, Pablo; Stam, Ronald W. (Ferrata Storti Foundation, 2019)
    B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell acute lymphoblastic leukemia remains fatal, especially in patients with t(4;11), present in ~80% of cases. The pathogenesis of ...

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