Browsing by Author "Vara, Covadonga"

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  • Principles of 3D chromosome folding and evolutionary genome reshuffling in mammals
    Álvarez-González, Lucía; Arias-Sardá, Cristina; Montes-Espuña, Laia; Marín-Gual, Laia; Vara, Covadonga; Lister, Nicholas C.; Cuartero, Yasmina; Garcia, Francisca; Deakin, Janine; Renfree, Marilyn B.; Robinson, Terence J.; Martí Renom, Marc A.; Waters, Paul D.; Farré, Marta; Ruiz Herrera, Aurora (Elsevier, 2022)
    Studying the similarities and differences in genomic interactions between species provides fertile grounds for determining the evolutionary dynamics underpinning genome function and speciation. Here, we describe the ...
  • The impact of chromosomal fusions on 3D genome folding and recombination in the germ line
    Vara, Covadonga; Paytuví Gallart, Andreu; Cuartero, Yasmina; Álvarez-González, Lucía; Marín-Gual, Laia; Garcia, Francisca; Florit-Sabater, Beatriu; Capilla, Laia; Sanchéz-Guillén, Rosa Ana; Sarrate, Zaida; Cigliano, Riccardo Aiese; Sanseverino, Walter; Searle, Jeremy B.; Ventura, Jacint; Martí Renom, Marc A.; Le Dily, François; Ruiz Herrera, Aurora (Nature Research, 2021)
    The spatial folding of chromosomes inside the nucleus has regulatory effects on gene expression, yet the impact of genome reshuffling on this organization remains unclear. Here, we take advantage of chromosome conformation ...
  • Three-dimensional genomic structure and cohesin occupancy correlate with transcriptional activity during spermatogenesis
    Vara, Covadonga; Paytuví Gallart, Andreu; Cuartero, Yasmina; Le Dily, François; Garcia, Francisca; Salvà-Castro, Judit; Gómez-H, Laura; Julià, Eva; Moutinho, Catia; Aiese Cigliano, Riccardo; Sanseverino, Walter; Fornas Carreño, Oscar; Pendás, Alberto M.; Heyn, Holger; Waters, Paul D.; Marti-Renom, Marc A.; Ruiz Herrera, Aurora (Elsevier, 2019)
    Mammalian gametogenesis involves dramatic and tightly regulated chromatin remodeling, whose regulatory pathways remain largely unexplored. Here, we generate a comprehensive high-resolution structural and functional atlas ...

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