Browsing by Author "Valle, Javier"

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  • Sandín, Daniel; Valle, Javier; Morata, Jordi; Andreu Martínez, David; Torrent Burgas, Marc (MDPI, 2022)
    Antimicrobial peptides (AMPs) are widely distributed molecules secreted mostly by cells of the innate immune system to prevent bacterial proliferation at the site of infection. As with classic antibiotics, continued treatment ...
  • Cavaco, Marco; Frutos, Silvia; Oliete, Paula; Valle, Javier; Andreu Martínez, David; Castanho, Miguel A.R.B.; Vila-Perelló, Miquel; Neves, Vera (American Chemical Society (ACS), 2021)
    The frequency of brain disease has increased significantly in the past years. After diagnosis, therapeutic options are usually limited, which demands the development of innovative therapeutic strategies. The use of ...
  • Cavaco, Marco; Fraga, Patrícia; Valle, Javier; Andreu Martínez, David; Castanho, Miguel A.R.B.; Neves, Vera (MDPI, 2021)
    Breast cancer (BC) is the most commonly diagnosed cancer in women and one of the most common causes of cancer-related deaths. Despite intense research efforts, BC treatment still remains challenging. Improved drug development ...
  • Cavaco, Marco; Valle, Javier; Flores, Isabel; Andreu Martínez, David; Castanho, Miguel A.R.B. (Wiley, 2021)
    Proteolytic instability is a critical limitation for peptide-based products. Although significant efforts are devoted to stabilize sequences against proteases/peptidases in plasma/serum, such approaches tend to be rather ...
  • Picón-Pagès, Pol; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Garcia-Buendia, Joan; Gutierrez, Daniela; Valle, Javier; Gómez-Casuso, Carmen E.S.; Sidelkivska, Valeriya; Alvarez, Alejandra; Perálvarez Marín, Alex; Suades, Albert; Fernàndez Busquets, Xavier; Andreu Martínez, David; Vicente García, Rubén, 1978-; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Elsevier, 2019)
    Alzheimer's disease (AD) is a neurodegenerative process characterized by the accumulation of extracellular deposits of amyloid β-peptide (Aβ), which induces neuronal death. Monomeric Aβ is not toxic but tends to aggregate ...
  • Cavaco, Marco; Fraga, Patrícia; Valle, Javier; Silva, Rúben D.M.; Gano, Lurdes; Correia, João D.G.; Andreu Martínez, David; Castanho, Miguel A.R.B.; Neves, Vera (BioMed Central, 2024)
    Blood-brain barrier (BBB) peptide-shuttles (BBBpS) are able to translocate the BBB and reach the brain. Despite the importance of brain targeting in pharmacology, BBBpS are poorly characterized. Currently, their development ...
  • Torralba, Johana; Arada, Igor de la; Partida-Hanon, Angélica; Rujas, Edurne; Arribas, Madalen; Insausti, Sara; Valotteau, Claire; Valle, Javier; Andreu Martínez, David; Caaveiro, José M. M.; Jiménez, María Ángeles; Apellániz, Beatriz; Redondo-Morata, Lorena; Nieva, José L. (Nature Research, 2022)
    Antibodies against the carboxy-terminal section of the membrane-proximal external region (C-MPER) of the HIV-1 envelope glycoprotein (Env) are considered as nearly pan-neutralizing. Development of vaccines capable of ...
  • González Magaldi, Mónica; Vázquez Calvo, Ángela; Torre, Beatriz G. de la; Valle, Javier; Andreu Martínez, David; Sobrino, Francisco (Public Library of Science (PLoS), 2015)
    Nonstructural protein 3A is involved in relevant functions in foot-and-mouth disease virus (FMDV) replication. FMDV 3A can form homodimers and preservation of the two hydrophobic α-helices (α1 and α2) that stabilize the ...
  • Sandín, Daniel; Valle, Javier; Chaves-Arquero, Belén; Prats-Ejarque, Guillem; Larrosa, María Nieves; González-López, Juan José; Jiménez, María Ángeles; Boix, Ester; Andreu Martínez, David; Torrent Burgas, Marc (American Chemical Society (ACS), 2021)
    Multidrug resistance against conventional antibiotics poses an important threat to human health. In this context, antimicrobial peptides (AMPs) have been extensively studied for their antibacterial activity and promising ...
  • Todorovski, Toni; Mendonça, Diogo A.; Fernandes-Siqueira, Lorena O.; Cruz-Oliveira, Christine; Valle, Javier; Cavaco, Marco; Limas, Fernanda I. V.; Neves, Vera; Cadima-Couto, Iris; Defaus, Sira; Salomé Veiga, Ana; Da Poian, Andrea T.; Castanho, Miguel A.R.B.; Andreu Martínez, David (MDPI, 2022)
    Viral disease outbreaks affect hundreds of millions of people worldwide and remain a serious threat to global health. The current SARS-CoV-2 pandemic and other recent geographically- confined viral outbreaks (severe acute ...
  • Oliveira, Filipa D.; Cavaco, Marco; Figueira, Tiago N.; Valle, Javier; Neves, Vera; Andreu Martínez, David; Gaspar, Diana; Castanho, Miguel A.R.B. (Wiley, 2022)
    The incidence of metastatic breast cancer (MBC) is increasing and the therapeutic arsenal available to fight it is insufficient. Brain metastases, in particular, represent a major challenge for chemotherapy as the impermeable ...
  • Bello Madruga, Roberto; Valle, Javier; Jiménez, M. Ángeles; Torrent Burgas, Marc; Montero Alejo, Vivian; Andreu Martínez, David (MDPI, 2023)
    β-defensins are one of the most abundant and studied families of antimicrobial peptides (AMPs). Because of their selective toxicity to bacterial membranes and a broad spectrum of microbicidal action, β-defensins are regarded ...
  • Pinto, Sandra N.; Dias, Susana A.; Cruz, Ana F.; Mil-Homens, Dalila; Fernandes, Fabio; Valle, Javier; Andreu Martínez, David; Prieto, Manuel; Castanho, Miguel A.R.B.; Coutinho, Ana; Salomé Veiga, Ana (Oxford University Press, 2019)
    Objectives: To investigate the mechanism of action at the molecular level of pepR, a multifunctional peptide derived from the Dengue virus capsid protein, against Staphylococcus aureus biofilms. Methods: Biofilm mass, ...
  • Bouzón-Arnáiz, Inés; Avalos-Padilla, Yunuen; Biosca, Arnau; Caño-Prades, Omar; Román-Álamo, Lucía; Valle, Javier; Andreu Martínez, David; Moita, Diana; Prudêncio, Miguel; Arce, Elsa M.; Muñoz-Torrero, Diego; Fernàndez Busquets, Xavier (BioMed Central, 2022)
    Background: By 2016, signs of emergence of Plasmodium falciparum resistance to artemisinin and partner drugs were detected in the Greater Mekong Subregion. Recently, the independent evolution of artemisinin resistance has ...
  • Cavaco, Marco; Pérez-Peinado, Clara, 1991-; Valle, Javier; Silva, Rúben D.M.; Gano, Lurdes; Correia, João D.G.; Andreu Martínez, David; Castanho, Miguel A.R.B.; Neves, Vera (Elsevier, 2024)
    Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by the absence of commonly targeted receptors. Unspecific chemotherapy is currently the main therapeutic option, with poor results. Another major ...
  • Cavaco, Marco; Pérez-Peinado, Clara, 1991-; Valle, Javier; Silva, Rúben D.M.; Correia, João D.G.; Andreu Martínez, David; Castanho, Miguel A.R.B.; Neves, Vera (Frontiers, 2020)
    The characterization of biologically active peptides relies heavily on the study of their efficacy, toxicity, mechanism of action, cellular uptake, or intracellular location, using both in vitro and in vivo studies. These ...
  • Regalado, Laura; Sario, Sara; Mendes, Rafael J.; Valle, Javier; Harvey, Peta J.; Teixeira, Cátia M.; Gomes, Paula; Andreu Martínez, David; Santos, Conceição (MDPI, 2023)
    The spotted-wing drosophila (Drosophila suzukii) is a polyphagous pest that causes severe damage and economic losses to soft-skinned fruit production. Current control methods are dominated by inefficient cultural practices ...

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