Browsing by Author "Valle, Javier"

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  • Antimicrobial peptides can generate tolerance by lag and interfere with antimicrobial therapy
    Sandín, Daniel; Valle, Javier; Morata, Jordi; Andreu Martínez, David; Torrent Burgas, Marc (MDPI, 2022)
    Antimicrobial peptides (AMPs) are widely distributed molecules secreted mostly by cells of the innate immune system to prevent bacterial proliferation at the site of infection. As with classic antibiotics, continued treatment ...
  • Conjugation of a blood brain barrier peptide shuttle to an Fc domain for brain delivery of therapeutic biomolecules
    Cavaco, Marco; Frutos, Silvia; Oliete, Paula; Valle, Javier; Andreu Martínez, David; Castanho, Miguel A.R.B.; Vila-Perelló, Miquel; Neves, Vera (American Chemical Society (ACS), 2021)
    The frequency of brain disease has increased significantly in the past years. After diagnosis, therapeutic options are usually limited, which demands the development of innovative therapeutic strategies. The use of ...
  • Development of breast cancer spheroids to evaluate cytotoxic response to an anticancer peptide
    Cavaco, Marco; Fraga, Patrícia; Valle, Javier; Andreu Martínez, David; Castanho, Miguel A.R.B.; Neves, Vera (MDPI, 2021)
    Breast cancer (BC) is the most commonly diagnosed cancer in women and one of the most common causes of cancer-related deaths. Despite intense research efforts, BC treatment still remains challenging. Improved drug development ...
  • Estimating peptide half‐life in serum from tunable, sequence‐related physicochemical properties
    Cavaco, Marco; Valle, Javier; Flores, Isabel; Andreu Martínez, David; Castanho, Miguel A.R.B. (Wiley, 2021)
    Proteolytic instability is a critical limitation for peptide-based products. Although significant efforts are devoted to stabilize sequences against proteases/peptidases in plasma/serum, such approaches tend to be rather ...
  • Human albumin impairs amyloid β-peptide fibrillation through its C-terminus: from docking modeling to protection against neurotoxicity in alzheimer's disease
    Picón-Pagès, Pol; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Garcia-Buendia, Joan; Gutierrez, Daniela; Valle, Javier; Gómez-Casuso, Carmen E.S.; Sidelkivska, Valeriya; Alvarez, Alejandra; Perálvarez Marín, Alex; Suades, Albert; Fernàndez Busquets, Xavier; Andreu Martínez, David; Vicente García, Rubén, 1978-; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Elsevier, 2019)
    Alzheimer's disease (AD) is a neurodegenerative process characterized by the accumulation of extracellular deposits of amyloid β-peptide (Aβ), which induces neuronal death. Monomeric Aβ is not toxic but tends to aggregate ...
  • Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope
    Torralba, Johana; Arada, Igor de la; Partida-Hanon, Angélica; Rujas, Edurne; Arribas, Madalen; Insausti, Sara; Valotteau, Claire; Valle, Javier; Andreu Martínez, David; Caaveiro, José M. M.; Jiménez, María Ángeles; Apellániz, Beatriz; Redondo-Morata, Lorena; Nieva, José L. (Nature Research, 2022)
    Antibodies against the carboxy-terminal section of the membrane-proximal external region (C-MPER) of the HIV-1 envelope glycoprotein (Env) are considered as nearly pan-neutralizing. Development of vaccines capable of ...
  • Peptides interfering 3A protein dimerization decrease FMDV multiplication
    González Magaldi, Mónica; Vázquez Calvo, Ángela; Torre, Beatriz G. de la; Valle, Javier; Andreu Martínez, David; Sobrino, Francisco (Public Library of Science (PLoS), 2015)
    Nonstructural protein 3A is involved in relevant functions in foot-and-mouth disease virus (FMDV) replication. FMDV 3A can form homodimers and preservation of the two hydrophobic α-helices (α1 and α2) that stabilize the ...
  • Rationally modified antimicrobial peptides from the N-terminal domain of human RNase 3 show exceptional serum stability
    Sandín, Daniel; Valle, Javier; Chaves-Arquero, Belén; Prats-Ejarque, Guillem; Larrosa, María Nieves; González-López, Juan José; Jiménez, María Ángeles; Boix, Ester; Andreu Martínez, David; Torrent Burgas, Marc (American Chemical Society (ACS), 2021)
    Multidrug resistance against conventional antibiotics poses an important threat to human health. In this context, antimicrobial peptides (AMPs) have been extensively studied for their antibacterial activity and promising ...
  • Targeting Zika virus with new brain- and placenta-crossing peptide-porphyrin conjugates
    Todorovski, Toni; Mendonça, Diogo A.; Fernandes-Siqueira, Lorena O.; Cruz-Oliveira, Christine; Valle, Javier; Cavaco, Marco; Limas, Fernanda I. V.; Neves, Vera; Cadima-Couto, Iris; Defaus, Sira; Salomé Veiga, Ana; Da Poian, Andrea T.; Castanho, Miguel A.R.B.; Andreu Martínez, David (MDPI, 2022)
    Viral disease outbreaks affect hundreds of millions of people worldwide and remain a serious threat to global health. The current SARS-CoV-2 pandemic and other recent geographically- confined viral outbreaks (severe acute ...
  • The antimetastatic breast cancer activity of the viral protein-derived peptide vCPP2319 as revealed by cellular biomechanics
    Oliveira, Filipa D.; Cavaco, Marco; Figueira, Tiago N.; Valle, Javier; Neves, Vera; Andreu Martínez, David; Gaspar, Diana; Castanho, Miguel A.R.B. (Wiley, 2022)
    The incidence of metastatic breast cancer (MBC) is increasing and the therapeutic arsenal available to fight it is insufficient. Brain metastases, in particular, represent a major challenge for chemotherapy as the impermeable ...
  • The mechanism of action of pepR, a viral-derived peptide, against Staphylococcus aureus biofilms
    Pinto, Sandra N.; Dias, Susana A.; Cruz, Ana F.; Mil-Homens, Dalila; Fernandes, Fabio; Valle, Javier; Andreu Martínez, David; Prieto, Manuel; Castanho, Miguel A.R.B.; Coutinho, Ana; Salomé Veiga, Ana (Oxford University Press, 2019)
    Objectives: To investigate the mechanism of action at the molecular level of pepR, a multifunctional peptide derived from the Dengue virus capsid protein, against Staphylococcus aureus biofilms. Methods: Biofilm mass, ...
  • The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures
    Bouzón-Arnáiz, Inés; Avalos-Padilla, Yunuen; Biosca, Arnau; Caño-Prades, Omar; Román-Álamo, Lucía; Valle, Javier; Andreu Martínez, David; Moita, Diana; Prudêncio, Miguel; Arce, Elsa M.; Muñoz-Torrero, Diego; Fernàndez-Busquets, Xavier (BioMed Central, 2022)
    Background: By 2016, signs of emergence of Plasmodium falciparum resistance to artemisinin and partner drugs were detected in the Greater Mekong Subregion. Recently, the independent evolution of artemisinin resistance has ...
  • To what extent do fluorophores bias the biological activity of peptides? A practical approach using membrane-active peptides as models
    Cavaco, Marco; Pérez-Peinado, Clara, 1991-; Valle, Javier; Silva, Rúben D.M.; Correia, João D.G.; Andreu Martínez, David; Castanho, Miguel A.R.B.; Neves, Vera (Frontiers, 2020)
    The characterization of biologically active peptides relies heavily on the study of their efficacy, toxicity, mechanism of action, cellular uptake, or intracellular location, using both in vitro and in vivo studies. These ...