Browsing by Author "Valjent, Emmanuel"

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  • Zimmer, Andreas; Valjent, Emmanuel; König, Monika; Zimmer, Anne M.; Robledo, Patricia, 1958-; Hahn, Heidi; Valverde Granados, Olga; Maldonado, Rafael, 1961- (Society for Neuroscience, 2001)
    The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show ...
  • Gutiérrez Martos, Miriam; Girard, Benoît; Mendonça Netto, Sueli; Perroy, Julie; Valjent, Emmanuel; Maldonado, Rafael, 1961-; Martín Sánchez, Miquel, 1971- (Wiley-Blackwell, 2018)
    High-palatable and caloric foods are widely overconsumed due to hedonic mechanisms that prevail over caloric necessities leading to overeating and overweight. The nucleus accumbens (NAc) is a key brain area modulating the ...
  • Valverde Granados, Olga; Maldonado, Rafael, 1961-; Valjent, Emmanuel; Zimmer, Anne M.; Zimmer, Andreas (Society for Neuroscience, 2000)
    The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Delta9-tetrahydrocannabinol ...
  • Puighermanal Puigvert, Emma, 1983-; Castell, Laia; Esteve-Codina, Anna; Melser, Su; Kaganovsky, Konstantin; Zussy, Charleine; Boubaker-Vitre, Jihane; Gut, Marta; Rialle, Stephanie; Kellendonk, Christoph; Sanz, Elisenda; Quintana, Albert; Marsicano, Giovanni; Martin, Miquel; Rubinstein, Marcelo; Girault, Jean-Antoine; Ding, Jun B.; Valjent, Emmanuel (Nature Research, 2020)
    Action control is a key brain function determining the survival of animals in their environment. In mammals, neurons expressing dopamine D2 receptors (D2R) in the dorsal striatum (DS) and the nucleus accumbens (Acb) jointly ...
  • Valjent, Emmanuel; Corvol, Jean-Christophe; Pagès, Christiane; Besson, Marie-J.; Maldonado, Rafael, 1961-; Caboche, Jocelyne (Society for Neuroscience, 2000)
    A central feature of drugs of abuse is to induce gene expression in discrete brain structures that are critically involved in behavioral responses related to addictive processes. Although extracellular signal-regulated ...
  • Martínez-Torres, Sara; Cutando Ruiz, Laura, 1985-; Pastor, Antonio; Kato, Ako; Sakimura, Kenji; Torre Fornell, Rafael de la; Valjent, Emmanuel; Maldonado, Rafael, 1961-; Kano, Masanobu; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2019)
    Monoacylglycerol lipase (MAGL) is the main enzyme implicated in the degradation of the most abundant endocannabinoid in the brain, 2-arachidonoylglycerol (2-AG), producing arachidonic acid (AA) and glycerol. MAGL pharmacological ...
  • Guegan, Thomas, 1983-; Cutando Ruiz, Laura, 1985-; Gangarossa, Giuseppe; Santini, Emanuela; Fisone, Gilberto; Martínez, Albert; Valjent, Emmanuel; Maldonado, Rafael, 1961-; Martín Sánchez, Miquel, 1971- (Elsevier, 2013)
    Food palatability produces behavioral modifications that resemble those induced by drugs of abuse. Palatability-induced behavioral changes require both, the activation of the endogenous cannabinoid system, and changes in ...
  • Guegan, Thomas, 1983-; Cutando Ruiz, Laura, 1985-; Ayuso, Eduard; Santini, Emanuela; Fisone, Gilberto; Bosch, Fatima; Martínez, Albert; Valjent, Emmanuel; Maldonado, Rafael, 1961-; Martín Sánchez, Miquel, 1971- (Elsevier, 2013)
    Palatability enhances food intake by hedonic mechanisms that prevail over caloric necessities. Different studies have demonstrated the role of endogenous cannabinoids in the mesocorticolimbic system in controlling food ...
  • Fasano, Stefania; D'Antoni, Angela; Orban, Paul C.; Valjent, Emmanuel; Putignano, Elena; Vara, Hugo; Pizzorusso, Tommaso; Giustetto, Maurizio; Yoon, Bongjune; Soloway, Paul; Maldonado, Rafael, 1961-; Caboche, Jocelyne; Brambilla, Riccardo (Elsevier, 2009)
    Background: Ras-extracellular signal-regulated kinase (Ras-ERK) signaling is central to the molecular machinery underlying cognitive functions. In the striatum, ERK1/2 kinases are co-activated by glutamate and dopamine ...
  • Doly, Stéphane; Quentin, Emily; Eddine, Raphaël; Tolu, Stefania; Fernández, Sebastián Pablo; Bertran González, Jesús; Valjent, Emmanuel; Belmer, Arnauld; Viñals Álvarez, Xavier, 1985-; Callebert, Jacques; Faure, Philippe; Meye, Frank Julius; Hervé, Denis; Robledo, Patricia, 1958-; Mameli, Manuel; Launay, Jean Marie; Maldonado, Rafael, 1961-; Maroteaux, Luc (Society for Neuroscience, 2017)
    Addiction is a maladaptive pattern of behavior following repeated use of reinforcing drugs in predisposed individuals, leading to lifelong changes. Common among these changes are alterations of neurons releasing dopamine ...