Browsing by Author "Valjent, Emmanuel"

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  • Zimmer, Andreas; Valjent, Emmanuel; König, Monika; Zimmer, Anne M.; Robledo, Patricia, 1958-; Hahn, Heidi; Valverde Granados, Olga; Maldonado, Rafael, 1961- (Society for Neuroscience, 2001)
    The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show ...
  • Gutiérrez Martos, Miriam; Girard, Benoît; Mendonça Netto, Sueli; Perroy, Julie; Valjent, Emmanuel; Maldonado, Rafael, 1961-; Martín Sánchez, Miquel, 1971- (Wiley-Blackwell, 2018)
    High-palatable and caloric foods are widely overconsumed due to hedonic mechanisms that prevail over caloric necessities leading to overeating and overweight. The nucleus accumbens (NAc) is a key brain area modulating the ...
  • Valverde Granados, Olga; Maldonado, Rafael, 1961-; Valjent, Emmanuel; Zimmer, Anne M.; Zimmer, Andreas (Society for Neuroscience, 2000)
    The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Delta9-tetrahydrocannabinol ...
  • Valjent, Emmanuel; Corvol, Jean-Christophe; Pagès, Christiane; Besson, Marie-J.; Maldonado, Rafael, 1961-; Caboche, Jocelyne (Society for Neuroscience, 2000)
    A central feature of drugs of abuse is to induce gene expression in discrete brain structures that are critically involved in behavioral responses related to addictive processes. Although extracellular signal-regulated ...
  • Martínez-Torres, Sara; Cutando Ruiz, Laura, 1985-; Pastor, Antonio; Kato, Ako; Sakimura, Kenji; Torre Fornell, Rafael de la; Valjent, Emmanuel; Maldonado, Rafael, 1961-; Kano, Masanobu; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2019)
    Monoacylglycerol lipase (MAGL) is the main enzyme implicated in the degradation of the most abundant endocannabinoid in the brain, 2-arachidonoylglycerol (2-AG), producing arachidonic acid (AA) and glycerol. MAGL pharmacological ...
  • Guegan, Thomas, 1983-; Cutando Ruiz, Laura, 1985-; Gangarossa, Giuseppe; Santini, Emanuela; Fisone, Gilberto; Martínez, Albert; Valjent, Emmanuel; Maldonado, Rafael, 1961-; Martín Sánchez, Miquel, 1971- (Elsevier, 2013)
    Food palatability produces behavioral modifications that resemble those induced by drugs of abuse. Palatability-induced behavioral changes require both, the activation of the endogenous cannabinoid system, and changes in ...
  • Guegan, Thomas, 1983-; Cutando Ruiz, Laura, 1985-; Ayuso, Eduard; Santini, Emanuela; Fisone, Gilberto; Bosch, Fatima; Martínez, Albert; Valjent, Emmanuel; Maldonado, Rafael, 1961-; Martín Sánchez, Miquel, 1971- (Elsevier, 2013)
    Palatability enhances food intake by hedonic mechanisms that prevail over caloric necessities. Different studies have demonstrated the role of endogenous cannabinoids in the mesocorticolimbic system in controlling food ...
  • Fasano, Stefania; D'Antoni, Angela; Orban, Paul C.; Valjent, Emmanuel; Putignano, Elena; Vara, Hugo; Pizzorusso, Tommaso; Giustetto, Maurizio; Yoon, Bongjune; Soloway, Paul; Maldonado, Rafael, 1961-; Caboche, Jocelyne; Brambilla, Riccardo (Elsevier, 2009)
    Background: Ras-extracellular signal-regulated kinase (Ras-ERK) signaling is central to the molecular machinery underlying cognitive functions. In the striatum, ERK1/2 kinases are co-activated by glutamate and dopamine ...
  • Doly, Stéphane; Quentin, Emily; Eddine, Raphaël; Tolu, Stefania; Fernández, Sebastián Pablo; Bertran González, Jesús; Valjent, Emmanuel; Belmer, Arnauld; Viñals Álvarez, Xavier, 1985-; Callebert, Jacques; Faure, Philippe; Meye, Frank Julius; Hervé, Denis; Robledo, Patricia, 1958-; Mameli, Manuel; Launay, Jean Marie; Maldonado, Rafael, 1961-; Maroteaux, Luc (Society for Neuroscience, 2017)
    Addiction is a maladaptive pattern of behavior following repeated use of reinforcing drugs in predisposed individuals, leading to lifelong changes. Common among these changes are alterations of neurons releasing dopamine ...