Browsing by Author "Urquiza, José M."

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  • Association of fish consumption and mercury exposure during pregnancy with metabolic health and inflammatory biomarkers in children
    Stratakis, Nikos; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Basagaña Flores, Xavier; Bustamante Pineda, Mariona; Casas Sanahuja, Maribel; Fossati, Serena; González Ruiz, Juan Ramón; Maitre, Léa; Urquiza, José M.; Vrijheid, Martine; Chatzi, Leda (JAMA Network, 2020)
    IMPORTANCE: The balance of mercury risk and nutritional benefit from fish intake during pregnancy for the metabolic health of offspring to date is unknown. OBJECTIVE: To assess the associations of fish intake and mercury ...
  • Association of prenatal exposure to endocrine-disrupting chemicals with liver injury in children
    Midya, Vishal; Andrušaitytė, Sandra; Basagaña Flores, Xavier; Casas Sanahuja, Maribel; Fossati, Serena; Gražulevičienė, Regina; Maitre, Léa; Urquiza, José M.; Vrijheid, Martine; Valvi, Damaskini, 1983- (American Medical Association, 2022)
    Importance: Prenatal exposures to endocrine-disrupting chemicals (EDCs) may increase the risk for liver injury in children; however, human evidence is scarce, and previous studies have not considered potential EDC-mixture ...
  • Determinants of the urinary and serum metabolome in children from six European populations
    Lau, Chung-Ho E.; Maitre, Léa; Urquiza, José M.; Casas Sanahuja, Maribel; Vrijheid, Martine; Coen, Muireann (BioMed Central, 2018)
    Background: Environment and diet in early life can affect development and health throughout the life course. Metabolic phenotyping of urine and serum represents a complementary systems-wide approach to elucidate ...
  • Early life multiple exposures and child cognitive function: A multi-centric birth cohort study in six European countries
    Julvez, Jordi; López Vicente, Mònica, 1988-; Warembourg, Charline; Maitre, Léa; Philippat, Claire; Gützkow, Kristine B.; Guxens Junyent, Mònica; Evandt, Jorunn; Andrušaitytė, Sandra; Burgaleta Díaz, Miguel, 1981-; Casas Sanahuja, Maribel; Chatzi, Leda; de Castro, Montserrat; Donaire González, David; Gražulevičienė, Regina; Hernandez-Ferrer, Carles, 1987-; Heude, Barbara; McEachan, Rosie; Mon-Williams, Mark; Nieuwenhuijsen, Mark J.; Robinson, Oliver; Sakhi, Amrit Kaur; Sebastián Gallés, Núria; Slama, Rémy; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Thomsen, Cathrine; Urquiza, José M.; Vafeiadi, Marina, 1983-; Basagaña Flores, Xavier; Vrijheid, Martine (Elsevier, 2021)
    Epidemiological studies mostly focus on single environmental exposures. This study aims to systematically assess associations between a wide range of prenatal and childhood environmental exposures and cognition. The study ...
  • Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study
    Maitre, Léa; Júlvez Calvo, Jordi; López Vicente, Mònica, 1988-; Warembourg, Charline; Tamayo-Uria, Ibon; Guxens Junyent, Mònica; Basagaña Flores, Xavier; Casas Sanahuja, Maribel; de Castro, Montserrat; Gonzalez, Juan Ramon; Hernandez-Ferrer, Carles, 1987-; Marquez, Sandra; Nieuwenhuijsen, Mark J.; Urquiza, José M.; Vrijheid, Martine (Elsevier, 2021)
    Background: Environmental exposures in early life influence the development of behavioral outcomes in children, but research has not considered multiple exposures. We therefore aimed to investigate the impact of a broad ...
  • Early-life environmental exposures and childhood obesity: an exposome-wide approach
    Vrijheid, Martine; Fossati, Serena; Maitre, Léa; Márquez, Sandra; Casas Sanahuja, Maribel; de Castro, Montserrat; Donaire González, David; Robinson, Oliver; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Urquiza, José M.; Valentín, Antònia; Warembourg, Charline; Nieuwenhuijsen, Mark J.; Basagaña Flores, Xavier; Chatzi, Leda (National Institute of Environmental Health Sciences, 2020)
    Background: Chemical and nonchemical environmental exposures are increasingly suspected to influence the development of obesity, especially during early life, but studies mostly consider single exposure groups. Objectives: ...
  • Early-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohort
    Agier, Lydiane; Basagaña Flores, Xavier; Maitre, Léa; Casas Sanahuja, Maribel; de Castro, Montserrat; Donaire González, David; Nieuwenhuijsen, Mark J.; Robinson, Oliver; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Urquiza, José M.; Valentín, Antònia; Vrijheid, Martine; Siroux, Valérie (Elsevier, 2019)
    Background: Several single-exposure studies have documented possible effects of environmental factors on lung function, but none has relied on an exposome approach. We aimed to evaluate the association between a broad range ...
  • Human Early Life Exposome (HELIX) study: a European population-based exposome cohort
    Maitre, Léa; De Bont, Jeroen, 1989-; Casas Sanahuja, Maribel; Robinson, Oliver; Basagaña Flores, Xavier; Borràs, Eva; Bustamante Pineda, Mariona; de Castro, Montserrat; Donaire González, David; Estivill, Xavier, 1955-; Fossati, Serena; González, Juan Ramón; Hernández-Ferrer, Carles; Júlvez Calvo, Jordi; Manzano Salgado, Cyntia Beatriz, 1987-; Sabidó Aguadé, Eduard, 1981-; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Urquiza, José M.; van Gent, Diana; Vives Usano, Marta, 1990-; Warembourg, Charline; Nieuwenhuijsen, Mark J.; Vrijheid, Martine (BMJ Publishing Group, 2018)
    PURPOSE: Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and ...
  • IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation
    Vento-Tormo, Roser; Company Nevado, Juan; Rodríguez Ubreva, Javier; de la Rica, Lorenzo; Urquiza, José M.; Javierre, Biola M.; Sabarinathan, Radhakrishnan; Luque, Ana; Esteller, Manel; Aran, Josep M.; Álvarez Errico, Damiana; Ballestar, Esteban (BioMed Central, 2016)
    Background: The role of cytokines in establishing specific transcriptional programmes in innate immune cells has long been recognized. However, little is known about how these extracellular factors instruct innate immune ...
  • In-utero and childhood chemical exposome in six European mother-child cohorts
    Haug, Line Småstuen; Casas Sanahuja, Maribel; Maitre, Léa; Basagaña Flores, Xavier; De Bont, Jeroen, 1989-; González, Juan Ramón; Sunyer Deu, Jordi; Urquiza, José M.; Vrijheid, Martine; Thomsen, Cathrine (Elsevier, 2018)
    Background: Harmonized data describing simultaneous exposure to a large number of environmental contaminants in-utero and during childhood is currently very limited. Objectives: To characterize concentrations of a large ...
  • Influence of the urban exposome on birth weight
    Nieuwenhuijsen, Mark J.; Basagaña Flores, Xavier; Urquiza, José M.; Maitre, Léa; de Castro, Montserrat; Valentín, Antònia; Donaire González, David; Dadvand, Payam; Vrijheid, Martine; Slama, Rémy (National Institute of Environmental Health Sciences, 2019)
    Background: The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating ...
  • Multi-omics signatures of the human early life exposome
    Maitre, Léa; Bustamante Pineda, Mariona; Hernández Ferrer, Carles; Vives Usano, Marta, 1990-; Ruiz-Arenas, Carlos; Pelegrí-Sisó, Dolors; Casas Sanahuja, Maribel; Sunyer Deu, Jordi; Nieuwenhuijsen, Mark J.; Urquiza, José M.; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Estivill, Xavier, 1955-; González, Juan Ramón; Vrijheid, Martine (Nature Research, 2022)
    Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) ...
  • Multiple environmental exposures in early-life and allergy-related outcomes in childhood
    Granum, Berit; Casas Sanahuja, Maribel; Warembourg, Charline; de Castro, Montserrat; Donaire González, David; Maitre, Léa; Robinson, Oliver; Tamayo-Uria, Ibon; Urquiza, José M.; Nieuwenhuijsen, Mark J.; Vrijheid, Martine (Elsevier, 2020)
    Introduction: Early onset and high prevalence of allergic diseases result in high individual and socio-economic burdens. Several studies provide evidence for possible effects of environmental factors on allergic diseases, ...
  • Obesity is associated with shorter telomeres in 8 year-old children
    Clemente Batalha Pardal, Diana, 1990-; Maitre, Léa; Bustamante Pineda, Mariona; Chatzi, Leda; Roumeliotaki, Theano; Fossati, Serena; Gražulevičienė, Regina; Gützkow, Kristine B.; Lepeule, Johanna; Martens, Dries S.; McEachan, Rosemary R.C.; Meltzer, Helle Margrete; Petraviciene, Inga; Slama, Rémy; Tamayo-Uria, Ibon; Urquiza, José M.; Vafeiadi, Marina, 1983-; Wright, John; Nawrot, Tim S.; Vrijheid, Martine (Nature Research, 2019)
    Telomere length is considered a biomarker of biological aging. Shorter telomeres and obesity have both been associated with age-related diseases. To evaluate the association between various indices of obesity with leukocyte ...
  • Paternal body mass index and offspring DNA methylation: findings from the PACE consortium
    Sharp, Gemma C.; Alfano, Rossella; Ghantous, Akram; Urquiza, José M.; Rifas-Shiman, Sheryl L.; Page, Christian M.; Jin, Jianping; Fernández-Barrés, Sílvia; Santorelli, Gillian; Tindula, Gwen; Pregnancy and Childhood Epigenetics (PACE) consortium (Oxford University Press, 2021)
    Background: Accumulating evidence links paternal adiposity in the periconceptional period to offspring health outcomes. DNA methylation has been proposed as a mediating mechanism, but very few studies have explored this ...
  • Prenatal and childhood exposure to air pollution and traffic and the risk of liver injury in European children
    Garcia, Erika; Maitre, Léa; Basagaña Flores, Xavier; Casas Sanahuja, Maribel; de Castro, Montserrat; Fossati, Serena; Nieuwenhuijsen, Mark J.; Urquiza, José M.; Vrijheid, Martine; Chatzi, Leda (Wolters Kluwer (LWW), 2021)
    Background: Nonalcoholic fatty liver disease is the most prevalent pediatric chronic liver disease. Experimental studies suggest effects of air pollution and traffic exposure on liver injury. We present the first large-scale ...
  • Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts
    Papadopoulou, Eleni, 1985-; Basagaña Flores, Xavier; Casas Sanahuja, Maribel; Fossati, Serena; Maitre, Léa; Sabidó Aguadé, Eduard, 1981-; Borràs, Eva; Urquiza, José M.; Vrijheid, Martine; Chatzi, Leda (Elsevier, 2021)
    Developing children are particularly vulnerable to the effects of exposure to per- and polyfluoroalkyl substances (PFAS), a group of endocrine disrupting chemicals. We hypothesized that early life exposure to PFASs is ...
  • Prenatal environmental exposures associated with sex differences in childhood obesity and neurodevelopment
    Cáceres, Alejandro; Carreras Gallo, Natàlia; Bustamante Pineda, Mariona; Maitre, Léa; Nieuwenhuijsen, Mark J.; Stratakis, Nikos; Urquiza, José M.; Casas Sanahuja, Maribel; Vrijheid, Martine; González, Juan Ramón (BioMed Central, 2023)
    Background: Obesity and neurodevelopmental delay are complex traits that often co-occur and differ between boys and girls. Prenatal exposures are believed to influence children's obesity, but it is unknown whether exposures ...
  • Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age – An exposome-based approach in 5 European cohorts
    Jedynak, Paulina; Maitre, Léa; Guxens Junyent, Mònica; Julvez, Jordi; López Vicente, Mònica, 1988-; Sunyer Deu, Jordi; Casas Sanahuja, Maribel; Tamayo-Uria, Ibon; Urquiza, José M.; Basagaña Flores, Xavier; Vrijheid, Martine; Philippat, Claire (Elsevier, 2021)
    Background: Studies looking at associations between environmental chemicals and child behaviour usually consider only one exposure or family of exposures. Objective: This study explores associations between prenatal exposure ...
  • PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation
    Rica, Lorenzo de la; Rodríguez Ubreva, Javier; García, Mireia; Islam, Abul, 1978-; Urquiza, José M.; Hernando, Henar; Christensen, Jesper; Helin, Kristian; Gómez Vaquero, Carmen; Ballestar, Esteban (BioMed Central, 2013)
    Background: DNA methylation is a key epigenetic mechanism for driving and stabilizing cell-fate decisions. Local deposition and removal of DNA methylation are tightly coupled with transcription factor binding, although the ...