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Browsing by Author "Trincado Alonso, Juan Luis, 1987-"

Browsing by Author "Trincado Alonso, Juan Luis, 1987-"

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  • Nieto, Paula; Elosua-Bayés, Marc; Trincado Alonso, Juan Luis, 1987-; Marchese, Domenica, 1986-; Massoni-Badosa, Ramon; Nieto, Juan C.; Aguilar-Fernández, Sergio; Mereu, Elisabetta; Moutinho, Catia; Ruiz, Sara; Lorden, Patricia; Gut, Ivo Glynne; Heyn, Holger (Cold Spring Harbor Laboratory Press (CSHL Press), 2021)
    The tumor immune microenvironment is a main contributor to cancer progression and a promising therapeutic target for oncology. However, immune microenvironments vary profoundly between patients, and biomarkers for prognosis ...
  • Ramos-Muntada, Mireia; Trincado Alonso, Juan Luis, 1987-; Molina, Oscar (Wiley, 2022)
    B-cell acute lymphoblastic leukemia (B-ALL) is the commonest childhood cancer. High hyperdiploidy (HHD) identifies the most frequent cytogenetic subgroup in childhood B-ALL. Although hyperdiploidy represents an important ...
  • Franco Valls, Héctor; Tusquets-Uxó, Elsa; Sala Romanyà, Laura, 1989-; Val Casals, Maria; Peña Arranz, Raúl, 1976-; Iaconcig, Alessandra; Villarino, Álvaro; Jiménez-Arriola, Martín; Massó, Pere; Trincado Alonso, Juan Luis, 1987-; Eyras Jiménez, Eduardo; Muro, Andrés F.; Otero, Jorge; García de Herreros, Antonio; Baulida i Estadella, Josep, 1965- (BioMed Central, 2023)
    Background: As in most solid cancers, the emergence of cells with oncogenic mutations in the mammary epithelium alters the tissue homeostasis. Some soluble factors, such as TGFβ, potently modify the behavior of healthy ...
  • Rubio Pérez, Carlota; Trincado Alonso, Juan Luis, 1987-; Marchese, Domenica, 1986-; Moutinho, Catia; Ruiz, Sara; Parra Farré, Genís; Heyn, Holger; Seoane, Joan (Nature Research, 2021)
    Brain metastases are the most common tumor of the brain with a dismal prognosis. A fraction of patients with brain metastasis benefit from treatment with immune checkpoint inhibitors (ICI) and the degree and phenotype of ...
  • Trincado Alonso, Juan Luis, 1987-; Reixachs i Solé, Marina; Pérez-Granado, Judith; Fugmann, Tim; Sanz, Ferran; Yokota, Jun; Eyras Jiménez, Eduardo (Public Library of Science (PLoS), 2021)
    Immunotherapies provide effective treatments for previously untreatable tumors and identifying tumor-specific epitopes can help elucidate the molecular determinants of therapy response. Here, we describe a pipeline, ISOTOPE ...
  • Alamancos, Gael P.; Pagès Pinós, Amadís; Trincado Alonso, Juan Luis, 1987-; Bellora Pereyra, Nicolás; Eyras Jiménez, Eduardo (Cambridge University Press, 2015)
    Alternative splicing plays an essential role in many cellular processes and bears major relevance in the understanding of multiple diseases, including cancer. High-throughput RNA sequencing allows genome-wide analyses of ...
  • Trincado Alonso, Juan Luis, 1987-; Entizne, Juan Carlos; Hysenaj, Gerald; Singh, Babita, 1986-; Skalic, Miha, 1990-; Elliott, David, 1947-; Eyras Jiménez, Eduardo (BioMed Central, 2018)
    Despite the many approaches to study differential splicing from RNA-seq, many challenges remain unsolved, including computing capacity and sequencing depth requirements. Here we present SUPPA2, a new method that addresses ...
  • Trincado Alonso, Juan Luis, 1987-; Sebestyén, Endre; Pagès Pinós, Amadís; Eyras Jiménez, Eduardo (BioMed Central, 2016)
    Background: Phenotypic changes during cancer progression are associated with alterations in gene expression, which can be exploited to build molecular signatures for tumor stage identification and prognosis. However, it ...
  • García Hernández, Violeta; Arambilet, David; Guillén, Yolanda; Lobo-Jarne, Teresa; Maqueda, Maria; Gekas, Christos; González, Jessica; Iglesias, Arnau; Vega García, Nerea; Sentís Carreras, Inés 1990-; Trincado Alonso, Juan Luis, 1987-; Márquez-López, Ian; Heyn, Holger; Camós, Mireia; Espinosa Blay, Lluís; Bigas Salvans, Anna (Wiley, 2023)
    Understanding the molecular mechanisms that contribute to the appearance of chemotherapy resistant cell populations is necessary to improve cancer treatment. We have now investigated the role of β-catenin/CTNNB1 in the ...

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