Browsing by Author "Torre Fornell, Rafael de la"

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  • A comparison of acute pharmacological effects of methylone and MDMA administration in humans and oral fluid concentrations as biomarkers of exposure
    Poyatos, Lourdes; Papaseit Fontanet, Esther; Olesti Muñoz, Eulàlia, 1991-; Pérez Mañá, Clara; Ventura, Mireia; Carbón Mallol, Xoán; Grifell Guardia, Marc; Fonseca Casals, Francina, 1972-; Torrens, Marta; Torre Fornell, Rafael de la; Farré Albaladejo, Magí (MDPI, 2021)
    Considered the β-keto analogue of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), 3,4-Methylenedioxymethcathinone (methylone) is a synthetic cathinone. Over the years, methylone has been used as a substitute for ...
  • A lower olfactory capacity is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body Mass index in women.
    Pastor, Antonio; Fernández Aranda, Fernando; Fitó Colomer, Montserrat; Jiménez Murcia, Susana; Botella, Cristina; Fernández Real, Jose M.; Frühbeck, Gema; Tinahones Madueño, Francisco José; Fagundo, Ana B.; Rodríguez Rodríguez, Juan Francisco; Agüera, Zaida; Langohr, Klaus; Casanueva, Felipe F.; Torre Fornell, Rafael de la (Public Library of Science , 2016)
    The endocannabinoid (eCB) system can promote food intake by increasing odor detection in mice. The eCB system is over-active in human obesity. Our aim is to measure circulating eCB concentrations and olfactory capacity in ...
  • A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials
    Sola Llopis, Susana de; Torre Fornell, Rafael de la; Sánchez Benavides, Gonzalo; Benejam, Bessy; Cuenca Royo, Aida Ma, 1981-; Del Hoyo Soriano, Laura; Rodríguez, Joan; Catuara Solarz, Silvina, 1986-; Sánchez Gutiérrez, Judit; Dueñas-Espín, Iván, 1979-; Hernández, Gimena; Peña-Casanova, J. (Jordi); Langohr, Klaus; Videla, Sebastià; Blehaut, Henry; Farré Albaladejo, Magí; Dierssen, Mara; TESDAD Study Group (Frontiers, 2015)
    The recent prospect of pharmaceutical interventions for cognitive impairment of Down syndrome (DS) has boosted a number of clinical trials in this population. However, running the trials has raised some methodological ...
  • A phase 1, randomized double-blind, placebo controlled trial to evaluate safety and efficacy of epigallocatechin-3-gallate and cognitive training in adults with Fragile X syndrome
    Torre Fornell, Rafael de la; De Sola Llopis, Susana; Xicota Vila, Laura, 1987-; Cuenca Royo, Aida Ma, 1981-; Rodriguez, Joan; Gomis González, Maria, 1988-; Hernández, Gimena; Del Hoyo Soriano, Laura; Ozaita Mintegui, Andrés, 1969-; Dierssen, Mara; TESXF Study Group; Principe, Alessandro; Espadaler, Josep María; Roca, Laia; Del Hoyo Soriano, Laura; Farré Albaladejo, Magí; Fitó Colomer, Montserrat; León Jorba, Alba; Banea, Ovideo; Maldonado, Rafael, 1961-; Busquets Garcia, Arnau, 1985- (Elsevier, 2020)
    Background & aims: Despite the wide spectrum of experimental compounds tested in clinical trials, there is still no proven pharmacological treatment available for Fragile-X syndrome (FXS), since several targeted clinical ...
  • Acetaminophen-induced liver injury alters the Acyl ethanolamine-based anti-inflammatory signaling system in liver
    Rivera, Patricia; Pastor, Antonio; Arrabal, Sergio; Decara, Juan M.; Vargas, Antonio; Sánchez-Marín, Laura; Pavón, Francisco Javier; Serrano, Antonia; Bautista, Dolores; Boronat Rigol, Anna, 1990-; Torre Fornell, Rafael de la; Baixeras, Elena; Lucena, Maria Isabel; Rodríguez de Fonseca, Fernando; Suárez, Juan (Frontiers, 2017)
    Protective mechanisms against drug-induced liver injury are actively being searched to identify new therapeutic targets. Among them, the anti-inflammatory N-acyl ethanolamide (NAE)-peroxisome proliferators activated receptor ...
  • Active transmembrane drug transport in microgravity: a validation study using an ABC transporter model
    Vaquer, Sergi; Cuyàs, Elisabet; Rabadán, Arnau; González, Albert; Fenollosa, Felip; Torre Fornell, Rafael de la (F1000Research, 2014)
  • Acute effects of 2C-E in humans: an observational study
    Papaseit Fontanet, Esther; Olesti Muñoz, Eulàlia, 1991-; Pérez Mañá, Clara; Torrens, Marta; Grifell Guardia, Marc; Ventura, Mireia; Pozo Mendoza, Óscar J., 1975-; de Sousa Fernandes Perna, Elizabeth B.; Ramaekers, Johannes G.; Torre Fornell, Rafael de la; Farré Albaladejo, Magí (Frontiers, 2020)
    2,5-Dimethoxy-4-ethylphenethylamine (2C-E) is psychedelic phenylethylamine, with a chemical structure similar to mescaline, used as new psychoactive substance (NPS). It inhibits norepinephrine and serotonin uptake and, ...
  • Acute heroin intoxication in a baby chronically exposed to cocaine and heroin: a case report
    Joya, Xavier; Fríguls, Bibiana; Simó, Marta; Civit, Ester; Torre Fornell, Rafael de la; Palomeque, Antonio; Vall Combelles, Oriol; Pichini, Simona; García Algar, Oscar (BioMed Central, 2011)
    INTRODUCTION: Acute intoxication with drugs of abuse in children is often only the tip of the iceberg, actually hiding chronic exposure. Analysis using non-conventional matrices such as hair can provide long-term information ...
  • Acute pharmacological effects of 2C-B in humans: An observational study
    Papaseit Fontanet, Esther; Farré Albaladejo, Magí; Pérez Mañá, Clara; Torrens, Marta; Ventura, Mireia; Pujadas, Mitona; Torre Fornell, Rafael de la; González, Débora (Frontiers, 2018)
    2,5-dimethoxy-4-bromophenethylamine (2C-B) is a psychedelic phenylethylamine derivative, structurally similar to mescaline. It is a serotonin 5-hydroxytryptamine-2A (5-HT2A), 5-hydroxytryptamine-2B (5-HT2B), and ...
  • Acute pharmacological effects of oral and intranasal mephedrone: an observational study in humans
    Papaseit Fontanet, Esther; Olesti Muñoz, Eulàlia, 1991-; Pérez Mañá, Clara; Torrens, Marta; Fonseca Casals, Francina, 1972-; Grifell Guardia, Marc; Ventura, Mireia; Torre Fornell, Rafael de la; Farré Albaladejo, Magí (MDPI, 2021)
    Mephedrone (4-methylmethcathinone) is a synthetic cathinone with psychostimulant properties which remains one of the most popular new psychoactive substances (NPS). It is frequently used orally and/or intranasally. To date, ...
  • An increase in visceral fat is associated with a decrease in the taste and olfactory capacity
    Fernandez-Garcia, Jose Carlos; Alcaide, Juan; Santiago-Fernandez, Concepcion; Roca-Rodriguez, M.M.; Agüera, Zaida; Baños, Rosa M.; Botella, Cristina; Torre Fornell, Rafael de la; Fernández Real, Jose M.; Frühbeck, Gema; Gómez Ambrosi, Javier; Jiménez Murcia, Susana; Menchón, José M.; Casanueva, Felipe F.; Fernández Aranda, Fernando; Tinahones Madueño, Francisco José; Garrido-Sanchez, Lourdes (Public Library of Science (PLoS), 2017)
    Introduction: Sensory factors may play an important role in the determination of appetite and food choices. Also, some adipokines may alter or predict the perception and pleasantness of specific odors. We aimed to analyze ...
  • Analysis of free hydroxytyrosol in human plasma following the administration of olive oil.
    Pastor, Antonio; Rodríguez-Morató, Jose, 1987-; Olesti Muñoz, Eulàlia, 1991-; Pujadas Bastardes, Mitona; Pérez Mañá, Clara; Khymenets, Olha, 1974-; Fitó Colomer, Montserrat; Covas Planells, Maria Isabel; Solà, Rosa; Motilva, Maria-José; Farré Albaladejo, Magí; Torre Fornell, Rafael de la (Elsevier, 2016)
    Hydroxytyrosol (HT) from olive oil, a potent bioactive molecule with health benefits, has a poor bioavailability, its free form (free HT) being undetectable so far. This fact leads to the controversy whether attained HT ...
  • Application of the athlete biological passport approach to the detection of growth hormone doping
    Equey, Tristan; Pastor, Antonio; Torre Fornell, Rafael de la; Thomas, Andreas; Giraud, Sylvain; Thevis, Mario; Kuuranne, Tiia; Baume, Norbert; Barroso, Osquel; Aikin, Reid (Oxford University Press, 2022)
    Context: because of its anabolic and lipolytic properties, growth hormone (GH) use is prohibited in sport. Two methods based on population-derived decision limits are currently used to detect human GH (hGH) abuse: the hGH ...
  • Approaches to evaluate the pharmacology of new psychoactive substances
    Olesti Muñoz, Eulàlia, 1991- (Universitat Pompeu Fabra, 2018-11-29)
    In the last decade, the rapid emergence of a group of compounds known as novel psychoactive substances (NPS) has become a worrying problem due to their ambiguous legal status, their easy availability, their extensive ...
  • Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index
    Pardo, María Luisa; Crujeiras, Ana B.; Amil, María; Agüera, Zaida; Jiménez Murcia, Susana; Baños, Rosa M.; Botella, Cristina; Torre Fornell, Rafael de la; Estivill, Xavier, 1955-; Fagundo, Ana B.; Fernández Real, Jose M.; Fernández García, José C.; Frühbeck, Gema; Gómez Ambrosi, Javier; Rodríguez, Roser; Tinahones Madueño, Francisco José; Fernández Aranda, Fernando; Casanueva, Felipe F. (Hindawi, 2014)
    FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also ...
  • Beer phenolic composition of simple phenols, prenylated flavonoids and alkylresorcinols
    Boronat Rigol, Anna, 1990-; Soldevila-Domenech, Natalia; Rodríguez-Morató, Jose, 1987-; Martínez-Huélamo, Miriam; Lamuela-Raventós, Rosa M.; Torre Fornell, Rafael de la (MDPI, 2020)
    Beer is a fermented beverage with beneficial phenolic compounds and is widely consumed worldwide. The current study aimed to describe the content of three families of phenolic compounds with relevant biological activities: ...
  • Bioavailability of epigallocatechin gallate administered with different nutritional strategies in healthy volunteers
    Andreu Fernandez, Vicente; Almeida Toledano, Laura; Pizarro Lozano, Mª Nieves; Navarro-Tapia, Elisabet; Gómez-Roig, María Dolores; Torre Fornell, Rafael de la; García-Algar, Oscar (MDPI, 2020)
    The flavanol epigallocatechin gallate (EGCG) is being tested for the treatment of several diseases in humans. However, its bioavailability and pharmacokinetic profile needs a better understanding to enable its use in ...
  • Bioavailability study of a transdermal patch formulation of rivastigmine compared with exelon in healthy subjects
    Morte, Adelaida; Vaqué, Anna; Iniesta, Marc; Schug, Barbara; Koch, Cornelius; Torre Fornell, Rafael de la; Schurad, Bjoern (Springer, 2022)
    Background and objectives: rivastigmine is a reversible cholinesterase inhibitor indicated for the treatment of all stages of Alzheimer's disease (AD). Transdermal patch formulation allows smooth and continuous drug delivery. ...
  • Biomarkers and cognitive function in Down syndrome : validation for phenotyping cognitive impairment
    Xicota Vila, Laura, 1987- (Universitat Pompeu Fabra, 2016-10-27)
    Clinical trials seeking to improve cognitive performance are in dire need of biochemical biomarkers that reflect the processes taking place in the brain. In Down syndrome, this information is crucial to understand the ...
  • Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams-Beuren syndrome
    Navarro Romero, Alba, 1990-; Galera López, Lorena, 1993-; Ortiz Romero, Paula, 1994-; Llorente-Ovejero, Alberto; Los Reyes-Ramírez, Lucía de; Bengoetxea de Tena, Iker; Garcia-Elias Heras, Anna; Mas-Stachurska, Aleksandra; Reixachs i Solé, Marina; Pastor, Antonio; Torre Fornell, Rafael de la; Maldonado, Rafael, 1961-; Benito Villabriga, Begoña; Eyras Jiménez, Eduardo; Rodríguez-Puertas, Rafael; Campuzano Uceda, María Victoria; Ozaita Mintegui, Andrés, 1969- (eLife, 2022)
    Williams-Beuren syndrome (WBS) is a rare genetic multisystemic disorder characterized by mild-to-moderate intellectual disability and hypersocial phenotype, while the most life-threatening features are cardiovascular ...