Browsing by Author "Tilgner, Hagen, 1980-"

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  • Absence of canonical marks of active chromatin in developmentally regulated genes
    Pérez-Lluch, Sílvia; Blanco, Enrique; Tilgner, Hagen, 1980-; Curado, Joao; Ruiz-Romero, Marina; Corominas Guiu, Montserrat; Guigó Serra, Roderic (Nature Research, 2015)
    The interplay of active and repressive histone modifications is assumed to have a key role in the regulation of gene expression. In contrast to this generally accepted view, we show that the transcription of genes temporally ...
  • Deep sequencing of subcellular RNA fractions shows splicing to be predominantly co-transcriptional in the human genome but inefficient for lncRNAs
    Tilgner, Hagen, 1980-; Knowles, David G.; Johnson, Rory; Davis, Carrie A.; Chakrabortty, Sudipto; Djebali, Sarah; Curado, Joao; Snyder, Michael; Gingeras, Thomas R.; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press (CSHL Press), 2012)
    Splicing remains an incompletely understood process. Recent findings suggest that chromatin structure participates in its regulation. Here, we analyze the RNA from subcellular fractions obtained through RNA-seq in the cell ...
  • Erratum to: Promoter-like epigenetic signatures in exons displaying cell type-specific splicing
    Curado, Joao; Iannone, Camilla, 1984-; Tilgner, Hagen, 1980-; Valcárcel, J. (Juan); Guigó Serra, Roderic (BioMed Central, 2016)
    After the publication of this work [1] an error was noticed in Fig. 7. The panel‘h’ is missing from Fig. 7. Please see the corrected figure below. The publisher apologises for this error.
  • From chromatin to splicing: RNA-processing as a total artwork
    Tilgner, Hagen, 1980-; Guigó Serra, Roderic (Taylor & Francis (Routledge), 2010)
    RNA plays a central role in the determination of the phenotype of the cell. The molecular mechanisms involved in primary RNA synthesis and subsequent post-processing are not completely understood, but there is increasing ...
  • Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast
    Maxwell, Christopher A.; Guigó Serra, Roderic; Curado, Joao; Tilgner, Hagen, 1980-; Pujana, Miguel Angel (Public Library of Science (PLoS), 2011)
    Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue organization is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of stem and progenitor cells in normal ...
  • Landscape of transcription in human cells
    Djebali, Sarah; Merkel, Angelika; Tanzer, Andrea; Lagarde, Julien; Röder, Maik; Curado, Joao; Derrien, Thomas; Ferreira, Pedro G.; González, David; Johnson, Rory; Kingswood, Colin; Ribeca, Paolo; Sammeth, Michael; Skancke, Jorgen; Tilgner, Hagen, 1980-; Guigó Serra, Roderic; Gingeras, Thomas R. (Nature Publishing Group, 2012)
    Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic ...
  • Modelling splicing
    Tilgner, Hagen, 1980- (Universitat Pompeu Fabra, 2011-06-02)
    L’Splicing de les molècules d’ARN és el procés pel qual les seqüències interposades (“introns”) s’eliminen, i les seqüències restants es concatenen per a formar l’ARN madur. La investigació recent mostra que gairebé tots els ...
  • Promoter-like epigenetic signatures in exons displaying cell type-specific splicing
    Curado, Joao; Iannone, Camilla, 1984-; Tilgner, Hagen, 1980-; Valcárcel, J. (Juan); Guigó Serra, Roderic (BioMed Central, 2015)
    Background. Pre-mRNA splicing occurs mainly co-transcriptionally, and both nucleosome density and histone modifications have been proposed to play a role in splice site recognition and regulation. However, the extent and ...
  • Role of six single nucleotide polymorphisms, risk factors in coronary disease, in OLR1 alternative splicing
    Tejedor Vaquero, Juan Ramón, 1984-; Tilgner, Hagen, 1980-; Iannone, Camilla, 1984-; Guigó Serra, Roderic; Valcárcel, J. (Juan) (Cambridge University Press, 2015)
    The OLR1 gene encodes the oxidized low-density lipoprotein receptor (LOX-1), which is responsible for the cellular uptake of oxidized LDL (Ox-LDL), foam cell formation in atheroma plaques and atherosclerotic plaque rupture. ...
  • The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression
    Derrien, Thomas; Johnson, Rory; Bussotti, Giovanni, 1983-; Tanzer, Andrea; Djebali, Sarah; Tilgner, Hagen, 1980-; Guernec, Gregory; Martin, David; Merkel, Angelika; Knowles, David G.; Lagarde, Julien; Veeravalli, Lavanya; Ruan, Xiaoan; Ruan, Yijun; Lassmann, Timo; Carninci, Piero; Brown, James B.; Lipovich, Leonard; González, José M.; Thomas, Mark; Davis, Carrie A.; Shiekhattar, Ramin; Gingeras, Thomas R.; Hubbard, Tim J.; Notredame, Cedric; Harrow, Jennifer; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press (CSHL Press), 2012)
    The human genome contains many thousands of long noncoding RNAs (lncRNAs). While several studies have demonstrated compelling biological and disease roles for individual examples, analytical and experimental approaches to ...