Browsing by Author "Tieves, Florian"

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  • Selective Synthesis of the Human Drug Metabolite 5′-Hydroxypropranolol by an Evolved Self-Sufficient Peroxygenase
    Gomez de Santos, Patricia; Cañellas, Marina; Tieves, Florian; Younes, Sabry H. H.; Molina-Espeja, Patricia; Hofrichter, Martin; Hollmann, Frank; Guallar i Tasies, Víctor; Alcalde, Miguel Angel (American Chemical Society (ACS), 2018)
    Propranolol is a widely used beta-blocker that is metabolized by human liver P450 monooxygenases into equipotent hydroxylated human drug metabolites (HDMs). It is paramount for the pharmaceutical industry to evaluate the ...