Browsing by Author "Szu-Tu, Chelsea"

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  • Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia
    Beneyto Calabuig, Sergi; Szu-Tu, Chelsea; Velten, Lars (Elsevier, 2023)
    Inter-patient variability and the similarity of healthy and leukemic stem cells (LSCs) have impeded the characterization of LSCs in acute myeloid leukemia (AML) and their differentiation landscape. Here, we introduce ...
  • Fast and inexpensive whole-genome sequencing library preparation from intact yeast cells
    Vonesch, Sibylle C.; Li, Shengdi; Szu-Tu, Chelsea; Henning, Bianca P.; Dobrev, Nikolay; Steinmetz, Lars M. (Oxford University Press, 2021)
    Through the increase in the capacity of sequencing machines massively parallel sequencing of thousands of samples in a single run is now possible. With the improved throughput and resulting drop in the price of sequencing, ...
  • Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics
    Velten, Lars; Story, Benjamin A.; Hernández-Malmierca, Pablo; Raffel, Simon; Leonce, Daniel R.; Milbank, Jennifer; Paulsen, Malte; Demir, Aykut; Szu-Tu, Chelsea; Frömel, Robert; Lutz, Christoph; Novak, Daniel; Jann, Johann-Christoph; Pabst, Caroline; Boch, Tobias; Hofmann, Wolf-Karsten; Müller-Tidow, Carsten; Trumpp, Andreas; Haas, Simon; Steinmetz, Lars M. (Nature Research, 2021)
    Cancer stem cells drive disease progression and relapse in many types of cancer. Despite this, a thorough characterization of these cells remains elusive and with it the ability to eradicate cancer at its source. In acute ...

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