Browsing by Author "Stadhouders, Ralph"

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  • Stik, Grégoire; Vidal, Enrique; Barrero, Mercedes; Cuartero, Sergi; Vila-Casadesús, Maria; Mendieta Esteban, Julen, 1992-; Tian, Tian V.; Choi, Jinmi; Berenguer, Clara; Abad, Amaya; Borsari, Beatrice, 1992-; Le Dily, François; Cramer, Patrick; Martí Renom, Marc A.; Stadhouders, Ralph; Graf, T. (Thomas) (Nature Research, 2020)
    Three-dimensional organization of the genome is important for transcriptional regulation1-7. In mammals, CTCF and the cohesin complex create submegabase structures with elevated internal chromatin contact frequencies, ...
  • Vivori, Claudia, 1989-; Papasaikas, Panagiotis; Stadhouders, Ralph; Di Stefano, Bruno, 1984-; Ribó Rubio, Anna; Berenguer, Clara; Generoso, Serena Francesca, 1988-; Mallol, Anna; Sardina, Jose Luis; Payer, Bernhard; Graf, T. (Thomas); Valcárcel, J. (Juan) (BioMed Central, 2021)
    Background: Somatic cell reprogramming is the process that allows differentiated cells to revert to a pluripotent state. In contrast to the extensively studied rewiring of epigenetic and transcriptional programs required ...
  • Vidal Ocabo, Enrique; Le Dily, François; Quilez Oliete, Javier; Stadhouders, Ralph; Cuartero, Yasmina; Graf, T. (Thomas); Martí Renom, Marc A.; Beato, Miguel; Filion, Guillaume (Oxford University Press, 2018)
    The three-dimensional conformation of genomes is an essential component of their biological activity. The advent of the Hi-C technology enabled an unprecedented progress in our understanding of genome structures. However, ...
  • Stikker, Bernard S.; Stik, Grégoire; van Ouwerkerk, Antoinette F.; Trap, Lianne; Spicuglia, Salvatore; Hendriks, Rudi W.; Stadhouders, Ralph (BioMed Central, 2022)
    Genome-wide association studies have identified 3p21.31 as the main risk locus for severe COVID-19, although underlying mechanisms remain elusive. We perform an epigenomic dissection of 3p21.31, identifying a CTCF-dependent ...
  • Lucic, Bojana; Chen, Heng-Chang; Kuzman, Maja; Zorita, Eduard; Wegner, Julia; Minneker, Vera; Wang, Wei; Fronza, Raffaele; Laufs, Stefanie; Schmidt, Manfred; Stadhouders, Ralph; Roukos, Vassilis; Vlahovicek, Kristian; Filion, Guillaume; Lusic, Marina (Nature Research, 2019)
    HIV-1 recurrently targets active genes and integrates in the proximity of the nuclear pore compartment in CD4+ T cells. However, the genomic features of these genes and the relevance of their transcriptional activity for ...
  • Lim, Ai Ing; Stadhouders, Ralph; Graf, T. (Thomas); Di Santo, James P. (Elsevier, 2017)
    Innate lymphoid cells (ILCs) represent innate versions of T helper and cytotoxic T cells that differentiate from committed ILC precursors (ILCPs). How ILCPs give rise to mature tissue-resident ILCs remains unclear. Here, ...
  • Stadhouders, Ralph; Vidal Ocabo, Enrique; Serra, François; Di Stefano, Bruno, 1984-; Le Dily, François; Quilez Oliete, Javier; Gómez, Antonio; Collombet, Samuel; Berenguer, Clara; Cuartero, Yasmina; Hecht, Jochen; Filion, Guillaume; Beato, Miguel; Martí Renom, Marc A.; Graf, T. (Thomas) (Nature Publishing Group, 2018)
    Chromosomal architecture is known to influence gene expression, yet its role in controlling cell fate remains poorly understood. Reprogramming of somatic cells into pluripotent stem cells (PSCs) by the transcription factors ...
  • Di Stefano, Marco; Stadhouders, Ralph; Farabella, Irene; Castillo Andreo, David; Serra, François; Graf, T. (Thomas); Marti-Renom, Marc A. (Nature Research, 2020)
    Chromosome structure is a crucial regulatory factor for a wide range of nuclear processes. Chromosome conformation capture (3C)-based experiments combined with computational modelling are pivotal for unveiling 3D chromosome ...
  • Brouwer, Rutger W.; Hout, Mirjam C. van den; IJcken, Wilfred F. van; Soler, Eric; Stadhouders, Ralph (Humana Press (Springer Imprint), 2017)
    The development and widespread implementation of chromosome conformation capture (3C) technology has allowed unprecedented new insight into how chromosomes are folded in three-dimensional (3D) space. 3C and its derivatives ...

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