Browsing by Author "Soriano Tarraga, Carolina"

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  • Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study
    Cullell, Natalia; Soriano Tarraga, Carolina; Gallego-Fabrega, Cristina; Cárcel-Márquez, Jara; Muiño, Elena; Llucià-Carol, Laia; Lledós, Miquel; Esteller, Manel; Castro de Moura, Manuel; Montaner, Joan; Rosell, Anna; Delgado, Pilar; Martí-Fàbregas, Joan; Krupinski, Jerzy; Roquer, Jaume; Jiménez Conde, Jordi; Fernández-Cadenas, Israel (BioMed Central, 2022)
    Background and purpose: the neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play ...
  • Association of apolipoprotein E with intracerebral hemorrhage risk by race/ethnicity: a meta-analysis
    Marini, Sandro; Roquer, Jaume; Jiménez Conde, Jordi; Giralt-Steinhauer, Eva; Elosua Llanos, Roberto; Cuadrado-Godia, Elisa; Soriano Tarraga, Carolina; Anderson, Christopher D.; International Stroke Genetics Consortium (American Medical Association, 2019)
    Importance: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic ...
  • Biological Age is a predictor of mortality in Ischemic Stroke
    Soriano Tarraga, Carolina; Giralt-Steinhauer, Eva; Mola Caminal, Marina; Ois Santiago, Angel Javier; Rodríguez-Campello, Ana; Cuadrado-Godia, Elisa; Fernández-Cadenas, Israel; Cullell, Natalia; Roquer, Jaume; Jiménez Conde, Jordi (Nature Research, 2018)
    Age and stroke severity are the main mortality predictors after ischemic stroke. However, chronological age and biological age are not exactly concordant. Age-related changes in DNA methylation in multiple CpG sites across ...
  • DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques and blood tissues
    Gallego-Fabrega, Cristina; Cullell, Natalia; Soriano Tarraga, Carolina; Carrera, Caty; Torres-Aguila, Nuria P.; Muiño, Elena; Cárcel-Márquez, Jara; Castro de Moura, Manuel; Fernández Sanlés, Alba, 1988-; Esteller, Manel; Elosua Llanos, Roberto; Jiménez Conde, Jordi; Roquer, Jaume; Montaner, Joan; Krupinski, Jerzy; Fernández-Cadenas, Israel (Impact Journals, 2020)
    Background and purpose: Polymorphisms and serum levels of Matrix Metalloproteinases (MMP) and Tissue Inhibitor of Metalloproteinases (TIMP) have been studied with regard to atheromatous plaques and ischemic stroke, while ...
  • Epigenetic clock explains white matter hyperintensity burden irrespective of chronological age
    Jiménez-Balado, Joan; Giralt-Steinhauer, Eva; Fernández-Pérez, Isabel; Rey, Lucía; Cuadrado-Godia, Elisa; Ois, Ángel; Rodríguez-Campello, Ana; Soriano Tarraga, Carolina; Lazcano, Uxue; Macias-Gómez, Adrià; Suárez-Pérez, Antoni; Revert, Anna; Estragués-Gázquez, Isabel; Beltrán Mármol, Marlyn Briggith; Medrano-Martorell, Santiago; Capellades, Jaume; Roquer, Jaume; Jiménez Conde, Jordi (MDPI, 2023)
    In this manuscript we studied the relationship between WMH and biological age (B-age) in patients with acute stroke. We included in this study 247 patients with acute stroke recruited at Hospital del Mar having both ...
  • Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
    Min, Josine L.; Soriano Tarraga, Carolina; Giralt-Steinhauer, Eva; Ruiz Arenas, Carlos, 1990-; Jiménez Conde, Jordi; Roquer, Jaume; González, Juan Ramón; Bustamante Pineda, Mariona; Sunyer Deu, Jordi; Relton, Caroline (Nature Research, 2021)
    Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. In the present study, we describe results of DNAm quantitative trait ...
  • Glycated hemoglobin value combined with initial glucose levels for evaluating mortality risk in patients with ischemic stroke.
    Roquer, Jaume; Giralt-Steinhauer, Eva; Cerdà, Georgina; Rodríguez-Campello, Ana; Cuadrado-Godia, Elisa; Jiménez Conde, Jordi; Vivanco Hidalgo, Rosa María; Soriano Tarraga, Carolina; Roman Degano, Irene; Ois Santiago, Angel Javier (Karger, 2015)
    BACKGROUND: Hyperglycemia is a marker of poor outcome in acute ischemic stroke (IS) patients. We aimed at evaluating the effect of combined HbA1c and first glucose measurement values on 3-month mortality prediction. METHODS: ...
  • Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study.
    Sayols, Sergi; Subirana Cachinero, Isaac; Lluís Ganella, Carla, 1984-; Civeira, Fernando; Roquer, Jaume; Do, AN; Absher, Devin; Cenarro, A.; Muñoz, Dani; Soriano Tarraga, Carolina; Jiménez Conde, Jordi; Ordovás, José M.; Sentí Clapés, Mariano; Aslibekyan, Stella W.; Marrugat de la Iglesia, Jaume; Arnett, Donna K.; Elosua Llanos, Roberto (Oxford University Press, 2016)
    Lipid traits (total, low-densityand high-density lipoproteincholesterol, and triglycerides) are risk factors for cardiovascular disease. DNA methylation is an inherited but also modifiable epigenetic mark ...
  • Identification of a new locus and validation of previously reported loci showing differential methylation associated with smoking. The REGICOR study.
    Sayols, Sergi; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Salas, Lucas A.; Vilahur Chiaraviglio, Nadia, 1982-; Corella, Dolores; Muñoz, Dani; Segura, Antoni, 1952-; Jiménez Conde, Jordi; Moran, Sebastian; Soriano Tarraga, Carolina; Roquer, Jaume; Lopez-Farré, Antonio; Marrugat de la Iglesia, Jaume; Fitó Colomer, Montserrat; Elosua Llanos, Roberto (Taylor & Francis, 2015)
    Smoking increases the risk of many diseases and could act through changes in DNA methylation patterns. The aims of this study were to determine the association between smoking and DNA methylation throughout the genome at ...
  • Intracranial aneurysm classifier using phenotypic factors: an international pooled analysis
    Morel, Sandrine; Jiménez Conde, Jordi; Cuadrado-Godia, Elisa; Soriano Tarraga, Carolina; Bijlenga, Philippe (MDPI, 2022)
    Intracranial aneurysms (IAs) are usually asymptomatic with a low risk of rupture, but consequences of aneurysmal subarachnoid hemorrhage (aSAH) are severe. Identifying IAs at risk of rupture has important clinical and ...
  • Ischemic stroke patients are biologically older than their chronological age.
    Soriano Tarraga, Carolina; Giralt-Steinhauer, Eva; Mola Caminal, Marina; Vivanco Hidalgo, Rosa María; Ois Santiago, Angel Javier; Rodríguez‐Campello, Ana; Cuadrado-Godia, Elisa; Sayols, Sergi; Elosua Llanos, Roberto; Roquer, Jaume; Jiménez‐Conde, Jordi ( Impact Journals, 2016)
    Ischemic stroke is associated with aging. It is possible to predict chronological age by measuring age-related changes in DNA methylation from multiple CpG sites across the genome, known as biological age. The difference ...
  • Long-term cardiovascular prognosis after transient ischemic attack: Associated predictors
    Ois Santiago, Angel Javier; Zabalza, Ana; Moreira Villanueva, Antía; Cuadrado-Godia, Elisa; Jiménez Conde, Jordi; Giralt-Steinhauer, Eva; Rodríguez-Campello, Ana; Soriano Tarraga, Carolina; Roquer, Jaume (Lippincott Williams & Wilkins, 2018)
    OBJECTIVE: To determine long-term cardiovascular risk after TIA and to identify the factors associated with increased risk. METHODS: This was a prospective observational registry of TIA patients admitted to the emergency ...
  • Long-term stroke recurrence after transient ischemic attack: implications of etiology
    Ois Santiago, Angel Javier; Cuadrado-Godia, Elisa; Giralt-Steinhauer, Eva; Jiménez Conde, Jordi; Soriano Tarraga, Carolina; Rodríguez-Campello, Ana; Avellaneda Gómez, Carla; Cascales Lahoz, Diego; Fernández-Pérez, Isabel; Roquer, Jaume (Korean Stroke Society, 2019)
    Background and purpose: To analyze long-term stroke recurrence (SR) characteristics after transient ischemic attack (TIA) according to initial etiological classification. Methods: A prospective cohort of 706 TIA patients ...
  • RP11-362K2.2:RP11-767I20.1 Genetic variation is associated with post-reperfusion therapy parenchymal hematoma. A GWAS meta-analysis
    Muiño, Elena; Jiménez Conde, Jordi; Roquer, Jaume; Giralt-Steinhauer, Eva; Soriano Tarraga, Carolina; The Spanish Stroke Genetic Consortium (MDPI, 2021)
    Stroke is one of the most common causes of death and disability. Reperfusion therapies are the only treatment available during the acute phase of stroke. Due to recent clinical trials, these therapies may increase their ...
  • Sex-related differences in primary intracerebral hemorrhage
    Roquer, Jaume; Rodriguez Campello, Ana; Jimenez-Conde, Jordi; Cuadrado-Godia, Elisa; Giralt-Steinhauer, Eva; Vivanco Hidalgo, Rosa María; Soriano Tarraga, Carolina; Ois Santiago, Angel Javier (Lippincott Williams & Wilkins, 2016)
    OBJECTIVE: Little information is available about sex-related differences in intracerebral hemorrhage (ICH). This is a prospective observational study to describe the sex differences in demographics, vascular risk factors, ...
  • Short-term exposure to traffic-related air pollution and ischemic stroke onset in Barcelona, Spain
    Vivanco Hidalgo, Rosa María; Wellenius, Gregory A.; Basagaña Flores, Xavier; Cirach, Marta; González, Alejandra Gómez; Ceballos, Pablo de; Zabalza, Ana; Jiménez Conde, Jordi; Soriano Tarraga, Carolina; Giralt-Steinhauer, Eva; Alastuey, Andrés; Querol, Xavier; Sunyer Deu, Jordi; Roquer, Jaume (Elsevier, 2018)
    OBJECTIVE: To assess the relationship between short-term exposure to outdoor ambient air pollutants (fine particulate matter [PM2.5] and black carbon [BC]), ischemic stroke (IS) and its different subtypes, and the potential ...
  • The copy number variation and stroke (CaNVAS) risk and outcome study
    Cole, John W.; Jiménez Conde, Jordi; Lazcano Dobao, Uxue; Soriano Tarraga, Carolina; Grond-Ginsbach, Caspar (Public Library of Science (PLoS), 2021)
    Background and purpose: The role of copy number variation (CNV) variation in stroke susceptibility and outcome has yet to be explored. The Copy Number Variation and Stroke (CaNVAS) Risk and Outcome study addresses this ...