Browsing by Author "Soler, María José"

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  • ADAM17 inhibition may exert a protective effect on COVID-19
    Palau González, Vanesa; Riera, Marta; Soler, María José (Oxford University Press, 2020)
  • Antimyeloperoxidase and proteinase 3 antibodies for nephritis flare prediction in ANCA-associated-vasculitis
    Rodríguez, Eva; Latzke, Belén; Sierra Carpio, Milagros; Romera, Ana María; Siedel, Diego; Agraz, Irene; Soler, María José; García Carro, Clara; Draibe, Juliana; Prada, Francisco José de la; Villacorta, Javier; Buxeda, Anna; Sierra Ochoa, Adriana; Lozano, Inés; Durán, Xavier; Barrios Barrera, Clara; Pascual, Julio (Pascual Santos); Spanish Group for the Study of Glomerular Diseases (GLOSEN) (Oxford University Press, 2021)
    Background: The value of myeloperoxidase and proteinase 3 antibodies titers in the assessment of renal disease activity and flare prediction in patients with ANCA-associated-vasculitis (AAV) is not well-known. Methods: ...
  • Bloqueo del sistema renina-angiotensina-aldosterona en pacientes con enfermedad renal diabética avanzada
    Bermejo García, Sheila; García, Carles Oriol; Rodríguez García, Eva; Barrios Barrera, Clara; Otero, Sol; Mojal, Sergio; Pascual Santos, Julio; Soler, María José (Elsevier, 2018)
    BACKGROUND AND OBJECTIVES: Diabetic kidney disease is the leading cause of end-stage chronic kidney disease. The renin-angiotensin-aldosterone system (RAAS) blockade has been shown to slow the progression of diabetic kidney ...
  • Both specific endothelial and proximal tubular Adam17 deletion protect against diabetic nephropathy
    Palau González, Vanesa; Nugraha, Bramasta; Benito, David; Pascual Santos, Julio; Emmert, Maximilian Y.; Hoerstrup, Simon P.; Riera, Marta; Soler, María José (MDPI, 2021)
    ADAM17 is a disintegrin and metalloproteinase capable of cleaving the ectodomains of a diverse variety of molecules including TNF-α, TGF-α, L-selectin, and ACE2. We have previously demonstrated that renal ADAM17 is upregulated ...
  • Characterization of ACE and ACE2 Expression within Different Organs of the NOD Mouse
    Roca-Ho, Heleia; Riera Oliva, Marta; Palau González, Vanesa; Pascual Santos, Julio; Soler, María José (MDPI, 2017)
    Renin angiotensin system (RAS) is known to play a key role in several diseases such as diabetes, and renal and cardiovascular pathologies. Its blockade has been demonstrated to delay chronic kidney disease progression and ...
  • Crystal-induced podocytopathy producing collapsing focal segmental glomerulosclerosis in monoclonal gammopathy of renal significance: a case report
    Buxeda, Anna; Said, Samar; Nasr, Samih H.; Soler, María José; Howard, Mathew T.; Maguire, Leo J.; Fervenza, Fernando C. (Elsevier, 2021)
    Monoclonal gammopathy-associated crystalline podocytopathy causing collapsing focal segmental glomerulosclerosis (FSGS) is very rare and has been associated with pamidronate therapy. We present the case of a 53-year-old ...
  • Effect of insulin on ACE2 activity and kidney function in the non-obese diabetic mouse (PLoS ONE (2014))
    Riera Oliva, Marta; Márquez, Eva; Clotet, Sergi; Gimeno Beltran, Javier; Roca-Ho, Heleia; Lloreta Trull, Josep, 1958-; Juanpere, Nuria; Batlle, Daniel; Pascual Santos, Julio; Soler, María José (Public Library of Science (PLoS), 2014)
    We studied the non-obese diabetic (NOD) mice model because it develops autoimmune diabetes that resembles human type 1 diabetes. In diabetic mice, urinary albumin excretion (UAE) was ten-fold increased at an “early stage” ...
  • Endothelial ADAM17 expression in the progression of kidney injury in an obese mouse model of pre-diabetes
    Palau González, Vanesa; Jarrín, Josué; Villanueva, Sofia; Benito, David; Márquez, Eva; Rodríguez, Eva; Soler, María José; Oliveras, Anna; Gimeno, Javier; Sans Atxer, Laia; Crespo Barrio, Marta; Pascual Santos, Julio; Barrios Barrera, Clara; Riera Oliva, Marta (MDPI, 2021)
    Disintegrin and metalloproteinase domain 17 (ADAM17) activates inflammatory and fibrotic processes through the shedding of various molecules such as Tumor Necrosis Factor-α (TNF-α) or Transforming Growht Factor-α (TGF-α). ...
  • Endothelin Blockade in Diabetic Kidney Disease.
    Anguiano Gómez, Lidia; Riera Oliva, Marta; Pascual Santos, Julio; Soler, María José (MDPI, 2015)
    Diabetic kidney disease (DKD) remains the most common cause of chronic kidney disease and multiple therapeutic agents, primarily targeted at the renin-angiotensin system, have been assessed. Their only partial effectiveness ...
  • Exploring renal changes after bariatric surgery in patients with severe obesity
    Oliveras, Anna; Vázquez, Susana; Soler, María José; Galceran Herrera, Isabel; Duran Jordà, Xavier, 1974-; Goday Arno, Alberto; Benaiges Foix, David; Crespo Barrio, Marta; Pascual Santos, Julio; Riera Oliva, Marta (MDPI, 2022)
    Obesity-related hyperfiltration leads to an increased glomerular filtration rate (GFR) and hyperalbuminuria. These changes are reversible after bariatric surgery (BS). We aimed to explore obesity-related renal changes ...
  • Factores predictivos de nefropatía no diabética en pacientes diabéticos. Utilidad de la biopsia renal
    Bermejo García, Sheila; Soler, María José; Gimeno Beltran, Javier; Barrios Barrera, Clara; Rodríguez, Eva; Mojal, Sergio; Pascual Santos, Julio (Sociedad Española de Nefrologia, 2016)
    Antecedentes y objetivos: La afectación renal del diabético solo puede determinarse mediante biopsia renal, que presenta una elevada prevalencia de lesiones no diabéticas. Los objetivos del estudio fueron determinar la ...
  • Gonadectomy prevents the increase in blood pressure and glomerular injury in angiotensin-converting enzyme 2 knockout diabetic male mice. Effects on renin-angiotensin system.
    Clotet, Sergi; Soler, María José; Rebull, Marta; Gimeno Beltran, Javier; Gurley, Susan Bailey; Pascual Santos, Julio; Riera Oliva, Marta (Lippincott Williams & Wilkins, 2016)
    BACKGROUND: Angiotensin-converting enzyme 2 (ACE2) deletion worsens kidney injury, and its amplification ameliorates diabetic nephropathy. Male sex increases the incidence, prevalence, and progression of chronic kidney ...
  • Impact of recurrent acute kidney injury on patient outcomes
    Rodriguez García, Eva; Arias Cabrales, Carlos Enrique; Bermejo García, Sheila; Sierra Ochoa, Adriana; Burballa Tàrrega, Carla, 1988-; Soler, María José; Barrios Barrera, Clara (Karger (S. Karger AG), 2018)
    BACKGROUND/AIMS: Recurrent acute kidney injury (AKI) is common among patients after a first hospitalized AKI. However, little is known about the prognosis of recurrent AKI episodes in chronic kidney disease (CKD) development, ...
  • Kidney biopsy in patients with cancer along the last decade: a multicenter study
    Bolufer, Mónica; García Carro, Clara; Blasco Pelícano, Miquel; Quintana, Luis; Shabaka, Amir; Rabasco, Cristina; Draibe, Juliana; Merino, Anna; Melero, María Rosa; Alonso, Fabiola; Buxeda, Anna; Batalha, Paula; Visús, Maria Teresa; Soler, María José (MDPI, 2022)
    Background: currently, following the new advances in cancer treatments and the increasing prevalence of kidney disease in the population, more kidney biopsies are being performed. The aim of our study is to analyze clinical ...
  • Membrane attack complex and factor H in humans with acute kidney injury
    Rodriguez García, Eva; Gimeno Beltran, Javier; Arias Cabrales, Carlos Enrique; Barrios Barrera, Clara; Redondo Pachón, María Dolores; Soler, María José; Crespo Barrio, Marta; Sierra Ochoa, Adriana; Riera Oliva, Marta; Pascual Santos, Julio (Karger (S. Karger AG), 2018)
    BACKGROUND AND AIMS: Complement system seems to play an important role in the pathogenesis of Acute Kidney Injury (AKI). The aim of this study was to investigate the role of complement system in the pathogenesis of human ...
  • MMP-10 is increased in early stage diabetic kidney disease and can be reduced by renin-angiotensin system blockade
    Mora-Gutiérrez, José María; Rodríguez, José Antonio; Fernández-Seara, María A.; Orbe, Josune; Escalada, Francisco Javier; Soler, María José; Slon Roblero, María Fernanda; Riera Oliva, Marta; Páramo, José Antonio; García-Fernández, Nuria (Nature Research, 2020)
    Matrix metalloproteinases have been implicated in diabetic microvascular complications. However, little is known about the pathophysiological links between MMP-10 and the renin-angiotensin system (RAS) in diabetic kidney ...
  • Podocytopathy in patients with monoclonal gammopathy: three patients and literature review
    Ribas Closa, Andrés; Puche Gallego, Adrián; Gimeno, Javier; Sans Atxer, Laia; Barrios Barrera, Clara; Márquez, Eva; Naranjo‐Hans, Dolores; Lloveras Rubio, Belen; Lop Gros, Joan; Ramos, Natàlia; Soler, María José; Gabaldon, Alejandra; Crespo Barrio, Marta; Rodríguez, Eva (Oxford University Press, 2021)
    Background: renal manifestations of monoclonal gammopathies are of increasing interest among nephrologists. Typical manifestations include light chain cast nephropathy, amyloidosis or renal damage mediated by monoclonal ...
  • Redefining the role of ADAM17 in renal proximal tubular cells and its implications in an obese mouse model of pre-diabetes
    Palau González, Vanesa; Villanueva, Sofia; Jarrín, Josué; Benito, David; Márquez, Eva; Rodríguez, Eva; Soler, María José; Oliveras, Anna; Gimeno Beltran, Javier; Sans Atxer, Laia; Crespo Barrio, Marta; Pascual Santos, Julio; Barrios Barrera, Clara; Riera Oliva, Marta (MDPI, 2021)
    Acute and chronic kidney lesions induce an increase in A Disintegrin And Metalloproteinase domain 17 (ADAM17) that cleaves several transmembrane proteins related to inflammatory and fibrotic pathways. Our group has ...
  • Renin-angiotensin system blockers and the risk of COVID-19-related mortality in patients with kidney failure
    Soler, María José; Noordzij, Marlies; Abramowicz, Daniel; de Arriba, Gabriel; Basile, Carlo; van Buren, Marjolijn; Covic, Adrian; Crespo Barrio, Marta; Duivenvoorden, Raphaël; Massy, Ziad A.; Ortiz, Alberto; Sanchez, J. Emilio; Petridou, Emily; Stevens, Kate; White, Colin; Vart, Priya; Gansevoort, Ron T.; ERACODA Collaborators (American Society of Nephrology, 2021)
    Background and objectives: There is concern about potential deleterious effects of angiotensin-converting enzyme inhibitors (ACEis) and angiotensin II receptor blockers (ARBs) in patients with coronavirus disease 2019 ...
  • Risk factors associated with major complications after ultrasound-guided percutaneous renal biopsy of native kidneys
    Pombas, Beatriz; Sánchez Parrila, Juan; Radosevic, Aleksandar; Gimeno Beltran, Javier; Busto Barrera, Marcos; Barrios Barrera, Clara; Sans Atxer, Laia; Pascual Santos, Julio; Soler, María José (Karger (S. Karger AG), 2020)
    Introduction: Percutaneous renal biopsy (PRB) of native kidneys is an important tool for diagnosis and management of renal disease. In this study, we analyzed the success, safety, and risk complications of PRB in our center. ...