Browsing by Author "Solé, Carme"

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  • A genetic analysis reveals novel histone residues required for transcriptional reprogramming upon stress
    Viéitez Manrique, Cristina, 1984-; Martínez Cebrián, Gerard, 1992-; Solé, Carme; Böttcher, René; Potel, Clement M.; Savitski, Mikhail M.; Onnebo, Sara; Fabregat, Marc; Shilatifard, Ali; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Oxford University Press, 2020)
    Cells have the ability to sense, respond and adapt to environmental fluctuations. Stress causes a massive reorganization of the transcriptional program. Many examples of histone post-translational modifications (PTMs) have ...
  • Control of Cdc28 CDK1 by a stress-induced lncRNA
    Nadal Ribelles, Mariona, 1984-; Solé, Carme; Xu, Zhenyu; Steinmetz, Lars M.; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Elsevier, 2014)
    Genomic analysis has revealed the existence of a large number of long noncoding RNAs (lncRNAs) with different functions in a variety of organisms, including yeast. Cells display dramatic changes of gene expression upon ...
  • Control of Ubp3 ubiquitin protease activity by the Hog1 SAPK modulates transcription upon osmostress
    Solé, Carme; Nadal Ribelles, Mariona, 1984-; Kraft, Claudine; Peter, Matthias; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Nature Publishing Group, 2011)
    Protein ubiquitylation is a key process in the regulation of many cellular processes. The balance between the activity of ubiquitin ligases and that of proteases controls the level of ubiquitylation. In response to ...
  • Data-driven identification of inherent features of eukaryotic stress-responsive genes
    Latorre Doménech, Pablo, 1993-; Böttcher, René; Nadal Ribelles, Mariona, 1984-; Li, Constance H.; Solé, Carme; Martínez Cebrián, Gerard, 1992-; Boutros, Paul C.; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Oxford University Press, 2022)
    Living organisms are continuously challenged by changes in their environment that can propagate to stresses at the cellular level, such as rapid changes in osmolarity or oxygen tension. To survive these sudden changes, ...
  • H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes
    Nadal Ribelles, Mariona, 1984-; Mas Martín, Glòria; Millán Zambrano, Gonzalo; Solé, Carme; Ammerer, Gustav; Chávez, Sebastián; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Oxford University Press, 2015)
    Chromatin remodeling is essential for proper adaptation to extracellular stimuli. The p38-related Hog1 SAPK is an important regulator of transcription that mediates chromatin remodeling upon stress. Hog1 targets the RSC ...
  • Interaction Dynamics Determine Signaling and Output Pathway Responses
    Stojanovski, Klement; Ferrar, Tony; Benisty, Hannah, 1986-; Uschner, Friedemann; Delgado Blanco, Javier; Jimenez, Javier; Solé, Carme; Nadal Clanchet, Eulàlia de; Klipp, E., 1965-; Posas Garriga, Francesc; Serrano Pubull, Luis, 1982-; Kiel, Christina (Elsevier, 2017)
    The understanding of interaction dynamics in signaling pathways can shed light on pathway architecture and provide insights into targets for intervention. Here, we explored the relevance of kinetic rate constants of a key ...
  • A novel role for lncRNAs in cell cycle control during stress adaptation
    Solé, Carme; Nadal Ribelles, Mariona, 1984-; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Springer, 2015)
    Eukaryotic cells have developed sophisticated systems to constantly monitor changes in the extracellular environment and to orchestrate a proper cellular response. To maximize survival, cells delay cell-cycle progression ...
  • Phosphorylation and proteasome recognition of the mRNA-Binding protein Cth2 facilitates yeast adaptation to iron deficiency
    Romero, Antonia M.; Martínez Pastor, Mar; Du, Gang; Solé, Carme; Carlos, María; Vergara, Sandra V.; Sanvisens, Nerea; Wohlschlegel, James A.; Toczyski, David P.; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de; Martínez-Pastor, María T.; Thiele, Dennis J.; Puig, Sergi (American Society for Microbiology, 2018)
    Iron is an indispensable micronutrient for all eukaryotic organisms due to its participation as a redox cofactor in many metabolic pathways. Iron imbalance leads to the most frequent human nutritional deficiency in the ...
  • Regulation of transcription elongation in response to osmostress
    Silva, Andrea; Cavero, Santiago; Begley, Victoria; Solé, Carme; Böttcher, René; Chávez, Sebastián; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Public Library of Science (PLoS), 2017)
    Cells trigger massive changes in gene expression upon environmental fluctuations. The Hog1 stress-activated protein kinase (SAPK) is an important regulator of the transcriptional activation program that maximizes cell ...
  • Structural disruption of BAF chromatin remodeller impairs neuroblastoma metastasis by reverting an invasiveness epigenomic program
    Jiménez, Carlos; Antonelli, Roberta; Nadal-Ribelles, Mariona; Devis-Jauregui, Laura; Latorre Doménech, Pablo, 1993-; Solé, Carme; Masanas, Marc; Molero-Valenzuela, Adrià; Soriano, Aroa; Sánchez de Toledo, Josep; Llobet-Navas, David; Roma, Josep; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de; Gallego, Soledad; Moreno, Lucas; Segura, Miguel F. (BioMed Central, 2022)
    Background: Epigenetic programming during development is essential for determining cell lineages, and alterations in this programming contribute to the initiation of embryonal tumour development. In neuroblastoma, neural ...
  • Timing of gene expression in a cell-fate decision system
    Aymoz, Delphine; Solé, Carme; Pierre, Jean-Jerrold; Schmitt, Marta; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc; Pelet, Serge (Wiley-Blackwell, 2018)
    During development, morphogens provide extracellular cues allowing cells to select a specific fate by inducing complex transcriptional programs. The mating pathway in budding yeast offers simplified settings to understand ...