Listar por autoría "Shekari, Mahnaz"

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  • A multisite analysis of the concordance between visual image interpretation and quantitative analysis of [18F]flutemetamol amyloid PET images
    Bucci, Marco; Savitcheva, Irina; Farrar, Gill; Salvadó, Gemma; Collij, Lyduine E.; Doré, Vincent; Gispert López, Juan Domingo; Gunn, Roger; Hanseeuw, Bernard; Hansson, Oskar; Shekari, Mahnaz; Lhommel, Renaud; Molinuevo, José Luis; Rowe, Christopher; Sur, Cyrille; Whittington, Alex; Buckley, Christopher, 1948-; Nordberg, Agneta (Springer, 2021)
    Background: [18F]flutemetamol PET scanning provides information on brain amyloid load and has been approved for routine clinical use based upon visual interpretation as either negative (equating to none or sparse amyloid ...
  • Age, sex and APOE-ε4 modify the balance between soluble and fibrillar β-amyloid in non-demented individuals: topographical patterns across two independent cohorts
    Cacciaglia, Raffaele; Salvadó, Gemma; Molinuevo, José Luis; Shekari, Mahnaz; Falcón, Carles; Operto, Grégory; Suárez-Calvet, Marc; Milà Alomà, Marta; Sala, Arianna; Rodriguez-Vieitez, Elena; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Blennow, Kaj; Zetterberg, Henrik; Gispert López, Juan Domingo; Alzheimer’s Disease Neuroimaging Initiative; ALFA Study (Nature Research, 2022)
    Amyloid (Aβ) pathology is the earliest detectable pathophysiological event along the Alzheimer's continuum, which can be measured both in the cerebrospinal fluid (CSF) and by Positron Emission Tomography (PET). Yet, these ...
  • APOE-ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals
    Brugulat Serrat, Anna, 1986-; Sánchez Benavides, Gonzalo; Cacciaglia, Raffaele; Shekari, Mahnaz; Milà Alomà, Marta; Vilor Tejedor, Natàlia, 1988-; Operto, Grégory; Falcón, Carles; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; Minguillón, Carolina; Fauria, Karine; Suárez-Calvet, Marc; Gispert López, Juan Domingo; ALFA Study (Springer, 2023)
    Purpose: To determine whether the APOE-ε4 allele modulates the relationship between regional β-amyloid (Aβ) accumulation and cognitive change in middle-aged cognitively unimpaired (CU) participants. Methods: The 352 CU ...
  • Association of weight change with cerebrospinal fluid biomarkers and amyloid positron emission tomography in preclinical Alzheimer's disease
    Grau-Rivera, Oriol; Navalpotro Gómez, Irene; Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Milà Alomà, Marta; Arenaza Urquijo, Eider M.; Salvadó, Gemma; Sala Vila, Aleix; Shekari, Mahnaz; González de Echávarri, José Maria; Minguillón, Carolina; Niñerola-Baizán, Aida; Perissinotti, Andrés; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (BioMed Central, 2021)
    Background: Recognizing clinical manifestations heralding the development of Alzheimer's disease (AD)-related cognitive impairment could improve the identification of individuals at higher risk of AD who may benefit from ...
  • Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer's disease and neurodegeneration stratified by sex
    Cumplido-Mayoral, Irene; Operto, Grégory; Falcón, Carles; Shekari, Mahnaz; Cacciaglia, Raffaele; Milà Alomà, Marta; Minguillón, Carolina; Suárez-Calvet, Marc; Gispert López, Juan Domingo; OASIS study (eLife, 2023)
    Brain-age can be inferred from structural neuroimaging and compared to chronological age (brain-age delta) as a marker of biological brain aging. Accelerated aging has been found in neurodegenerative disorders like Alzheimer's ...
  • Cerebral amyloid-β load is associated with neurodegeneration and gliosis: Mediation by p-tau and interactions with risk factors early in the Alzheimer's continuum
    Salvadó, Gemma; Milà Alomà, Marta; Shekari, Mahnaz; Minguillón, Carolina; Fauria, Karine; Niñerola-Baizán, Aida; Perissinotti, Andrés; Kollmorgen, Gwendlyn; Buckley, Christopher, 1948-; Farrar, Gill; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Wiley, 2021)
    Introduction: The association between cerebral amyloid-β accumulation and downstream CSF biomarkers is not fully understood, particularly in asymptomatic stages. Methods: In 318 cognitively unimpaired participants, we ...
  • Cognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF biomarker profile
    Milà Alomà, Marta; Shekari, Mahnaz; Salvadó, Gemma; Gispert López, Juan Domingo; Arenaza Urquijo, Eider M.; Operto, Grégory; Falcón, Carles; Vilor Tejedor, Natàlia, 1988-; Grau-Rivera, Oriol; Sala Vila, Aleix; Sánchez Benavides, Gonzalo; González de Echávarri, José Maria; Minguillón, Carolina; Suárez-Calvet, Marc; Molinuevo, José Luis; ALFA Study (BioMed Central, 2021)
    Background: Understanding the changes that occur in the transitional stage between absent and overt amyloid-β (Aβ) pathology within the Alzheimer's continuum is crucial to develop therapeutic and preventive strategies. The ...
  • CSF synaptic biomarkers in the preclinical stage of Alzheimer disease and their association with MRI and PET: a cross-sectional study
    Milà Alomà, Marta; Brinkmalm, Ann; Ashton, Nicholas J.; Kvartsberg, Hlin; Shekari, Mahnaz; Operto, Grégory; Salvadó, Gemma; Falcon, Carles; Domingo Gispert, Juan; Vilor Tejedor, Natàlia, 1988-; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Sala Vila, Aleix; Sanchez-Benavides, Gonzalo; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Niñerola-Baizán, Aida; Perissinotti, Andrés; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Zetterberg, Henrik; Molinuevo, José Luis; Blennow, Kaj; Suárez-Calvet, Marc; ALFA Study (Lippincott Williams & Wilkins, 2021)
    Background and objectives: To determine whether CSF synaptic biomarkers are altered in the early preclinical stage of the Alzheimer continuum and associated with Alzheimer disease (AD) risk factors, primary pathology, and ...
  • Differences between plasma and cerebrospinal fluid glial fibrillary acidic protein levels across the alzheimer disease continuum
    Benedet, Andrea L.; Milà Alomà, Marta; Salvadó, Gemma; Shekari, Mahnaz; Operto, Gregory; Gispert López, Juan Domingo; Minguillón, Carolina; Molinuevo, José Luis; Suárez-Calvet, Marc; Translational Biomarkers in Aging and Dementia (TRIAD) study; ALFA Study; BioCogBank Paris Lariboisière cohort (American Medical Association, 2021)
    Importance: Glial fibrillary acidic protein (GFAP) is a marker of reactive astrogliosis that increases in the cerebrospinal fluid (CSF) and blood of individuals with Alzheimer disease (AD). However, it is not known whether ...
  • Differential effects of sleep on brain structure and metabolism at the preclinical stages of AD
    Stankeviciute, Laura; Falcón, Carles; Operto, Grégory; Garcia, Marina; Shekari, Mahnaz; Iranzo, Alex; Niñerola-Baizán, Aida; Perissinotti, Andrés; Minguillón, Carolina; Fauria, Karine; Molinuevo, José Luis; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Cacciaglia, Raffaele; Gispert López, Juan Domingo; Grau-Rivera, Oriol; ALFA Study (Wiley, 2023)
    Introduction: Poor sleep quality is associated with cognitive outcomes in Alzheimer's disease (AD). We analyzed the associations between self-reported sleep quality and brain structure and function in cognitively unimpaired ...
  • Genetic, vascular and amyloid components of cerebral blood flow in a preclinical population
    Padrela, Beatriz E.; Lorenzini, Luigi; Collij, Lyduine E.; Vállez García, David; Coomans, Emma; Ingala, Silvia; Tomassen, Jori; Deckers, Quinten; Shekari, Mahnaz; de Geus, Eco; van de Giessen, Elsmarieke; Ten Kate, Mara; Visser, Pieter Jelle; Barkhof, Frederik; Petr, Jan; den Braber, Anouk; Mutsaerts, Henk Jmm (SAGE Publications, 2023)
    Aging-related cognitive decline can be accelerated by a combination of genetic factors, cardiovascular and cerebrovascular dysfunction, and amyloid-β burden. Whereas cerebral blood flow (CBF) has been studied as a potential ...
  • Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are detected
    Suárez-Calvet, Marc; Milà Alomà, Marta; Gispert López, Juan Domingo; Salvadó, Gemma; Minguillón, Carolina; Shekari, Mahnaz; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; Sala Vila, Aleix; González de Echávarri, José Maria; Molinuevo, José Luis; ALFA Study (Wiley, 2020)
    In Alzheimer's disease (AD), tau phosphorylation in the brain and its subsequent release into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease evolution. The main aim of our study was ...
  • P-tau235: a novel biomarker for staging preclinical Alzheimer's disease
    Lantero Rodriguez, Juan; Snellman, Anniina; Benedet, Andrea L.; Milà Alomà, Marta; Camporesi, Elena; Montoliu-Gaya, Laia; Ashton, Nicholas J.; Vrillon, Agathe; Karikari, Thomas K.; Domingo Gispert, Juan; Salvadó, Gemma; Shekari, Mahnaz; Toomey, Christina E.; Lashley, Tammaryn L.; Zetterberg, Henrik; Suárez-Calvet, Marc; Brinkmalm, Gunnar; Rosa-Neto, Pedro; Blennow, Kaj (Wiley, 2021)
    Alzheimer's disease (AD) is characterised by a long preclinical phase. Although phosphorylated tau (p-tau) species such as p-tau217 and p-tau231 provide accurate detection of early pathological changes, other biomarkers ...
  • Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer's continuum
    Vilor Tejedor, Natàlia, 1988-; Ciampa, Iacopo; Operto, Grégory; Falcón, Carles; Suárez-Calvet, Marc; Crous-Bou, Marta; Shekari, Mahnaz; Arenaza Urquijo, Eider M.; Milà Alomà, Marta; Grau-Rivera, Oriol; Minguillón, Carolina; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Guigó Serra, Roderic; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (BioMed Central, 2021)
    Background: Perivascular spaces (PVS) have an important role in the elimination of metabolic waste from the brain. It has been hypothesized that the enlargement of PVS (ePVS) could be affected by pathophysiological mechanisms ...
  • Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer's disease
    Milà Alomà, Marta; Shekari, Mahnaz; Salvadó, Gemma; Ortiz Romero, Paula, 1994-; González-Escalante, Armand; Sánchez Benavides, Gonzalo; Minguillón, Carolina; Gispert López, Juan Domingo; Suárez-Calvet, Marc; Blennow, Kaj (Nature Research, 2022)
    Blood biomarkers indicating elevated amyloid-β (Aβ) pathology in preclinical Alzheimer's disease are needed to facilitate the initial screening process of participants in disease-modifying trials. Previous biofluid data ...
  • Quantification of [18 F]florbetaben amyloid-PET imaging in a mixed memory clinic population. The ABIDE project
    Collij, Lyduine E.; Salvadó, Gemma; de Wilde, Arno; Altomare, Daniele; Shekari, Mahnaz; Domingo Gispert, Juan; Bullich, Santiago; Stephens, Andrew W.; Barkhof, Frederik; Scheltens, Philip; Bouwman, Femke; van der Flier, Wiesje M. (Wiley, 2022)
    Introduction: we investigated amyloid-burden quantification in a mixed memory clinic population. Methods: [18 F]Florbetaben amyloid-PET (positron emission tomography) scans of 348 patients were visually read and quantified ...
  • Quantification of amyloid PET for future clinical use: a state-of-the-art review
    Pemberton, Hugh G.; Collij, Lyduine E.; Heeman, Fiona; Bollack, Ariane; Shekari, Mahnaz; Salvadó, Gemma; Lopes Alves, Isadora; Vallez Garcia, David; Battle, Mark; Buckley, Christopher, 1948-; Stephens, Andrew W.; Bullich, Santiago; Garibotto, Valentina; Barkhof, Frederik; Gispert López, Juan Domingo; Farrar, Gill; AMYPAD Consortium (Springer, 2022)
    Amyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer's disease (AD) pathogenesis. The overall load and spatial distribution of brain Aβ can be determined in vivo using positron emission ...
  • Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer's continuum
    Salvadó, Gemma; Milà Alomà, Marta; Shekari, Mahnaz; Operto, Grégory; Falcón, Carles; Cacciaglia, Raffaele; Minguillón, Carolina; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Gispert López, Juan Domingo; ALFA Study (SpringerOpen, 2022)
    Purpose: glial activation is one of the earliest mechanisms to be altered in Alzheimer's disease (AD). Glial fibrillary acidic protein (GFAP) relates to reactive astrogliosis and can be measured in both cerebrospinal fluid ...
  • Subjective cognitive decline and anxious/depressive symptoms during the COVID-19 pandemic: what is the role of stress perception, stress resilience, and β-amyloid?
    Akinci, Muge; Sánchez Benavides, Gonzalo; Brugulat Serrat, Anna, 1986-; Peña-Gómez, Cleofé; Palpatzis, Eleni; Shekari, Mahnaz; Deulofeu, Carme; Fuentes-Julian, Sherezade; Salvadó, Gemma; González de Echávarri, José Maria; Suárez-Calvet, Marc; Minguillón, Carolina; Fauria, Karine; Molinuevo, José Luis; Domingo Gispert, Juan; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; ALFA Study (BioMed Central, 2022)
    Background: the COVID-19 pandemic may worsen the mental health of people reporting subjective cognitive decline (SCD) and therefore their clinical prognosis. We aimed to investigate the association between the intensity ...
  • Visual assessment of [18F]flutemetamol PET images can detect early amyloid pathology and grade its extent
    Collij, Lyduine E.; Salvadó, Gemma; Shekari, Mahnaz; Lopes Alves, Isadora; Reimand, Juhan; Wink, Alle-Meije; Zwan, Marissa; Niñerola-Baizán, Aida; Perissinotti, Andrés; Scheltens, Philip; Ikonomovic, Milos D.; Smith, Adrian P.L.; Farrar, Gill; Molinuevo, José Luis; Barkhof, Frederik; Buckley, Christopher, 1948-; van Berckel, Bart N. M. (Springer, 2021)
    Purpose: To investigate the sensitivity of visual read (VR) to detect early amyloid pathology and the overall utility of regional VR. Methods: [18F]Flutemetamol PET images of 497 subjects (ALFA+ N = 352; ADC N = 145) were ...

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