Browsing by Author "Shekari, Mahnaz"

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  • Bucci, Marco; Savitcheva, Irina; Farrar, Gill; Salvadó, Gemma; Collij, Lyduine E.; Doré, Vincent; Gispert López, Juan Domingo; Gunn, Roger; Hanseeuw, Bernard; Hansson, Oskar; Shekari, Mahnaz; Lhommel, Renaud; Molinuevo, José Luis; Rowe, Christopher; Sur, Cyrille; Whittington, Alex; Buckley, Christopher, 1948-; Nordberg, Agneta (Springer, 2021)
    Background: [18F]flutemetamol PET scanning provides information on brain amyloid load and has been approved for routine clinical use based upon visual interpretation as either negative (equating to none or sparse amyloid ...
  • Cacciaglia, Raffaele; Salvadó, Gemma; Molinuevo, José Luis; Shekari, Mahnaz; Falcón, Carles; Operto, Grégory; Suárez-Calvet, Marc; Milà Alomà, Marta; Sala, Arianna; Rodriguez-Vieitez, Elena; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Blennow, Kaj; Zetterberg, Henrik; Gispert López, Juan Domingo; Alzheimer’s Disease Neuroimaging Initiative; ALFA Study (Nature Research, 2022)
    Amyloid (Aβ) pathology is the earliest detectable pathophysiological event along the Alzheimer's continuum, which can be measured both in the cerebrospinal fluid (CSF) and by Positron Emission Tomography (PET). Yet, these ...
  • Brugulat Serrat, Anna, 1986-; Sánchez Benavides, Gonzalo; Cacciaglia, Raffaele; Shekari, Mahnaz; Milà Alomà, Marta; Vilor Tejedor, Natàlia, 1988-; Operto, Grégory; Falcón, Carles; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; Minguillón, Carolina; Fauria, Karine; Suárez-Calvet, Marc; Gispert López, Juan Domingo; ALFA Study (Springer, 2023)
    Purpose: To determine whether the APOE-ε4 allele modulates the relationship between regional β-amyloid (Aβ) accumulation and cognitive change in middle-aged cognitively unimpaired (CU) participants. Methods: The 352 CU ...
  • Grau-Rivera, Oriol; Navalpotro Gómez, Irene; Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Milà Alomà, Marta; Arenaza Urquijo, Eider M.; Salvadó, Gemma; Sala Vila, Aleix; Shekari, Mahnaz; González de Echávarri, José Maria; Minguillón, Carolina; Niñerola-Baizán, Aida; Perissinotti, Andrés; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (BioMed Central, 2021)
    Background: Recognizing clinical manifestations heralding the development of Alzheimer's disease (AD)-related cognitive impairment could improve the identification of individuals at higher risk of AD who may benefit from ...
  • Salvadó, Gemma; Milà Alomà, Marta; Shekari, Mahnaz; Minguillón, Carolina; Fauria, Karine; Niñerola-Baizán, Aida; Perissinotti, Andrés; Kollmorgen, Gwendlyn; Buckley, Christopher, 1948-; Farrar, Gill; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Wiley, 2021)
    Introduction: The association between cerebral amyloid-β accumulation and downstream CSF biomarkers is not fully understood, particularly in asymptomatic stages. Methods: In 318 cognitively unimpaired participants, we ...
  • Milà Alomà, Marta; Shekari, Mahnaz; Salvadó, Gemma; Gispert López, Juan Domingo; Arenaza Urquijo, Eider M.; Operto, Grégory; Falcón, Carles; Vilor Tejedor, Natàlia, 1988-; Grau-Rivera, Oriol; Sala Vila, Aleix; Sánchez Benavides, Gonzalo; González de Echávarri, José Maria; Minguillón, Carolina; Suárez-Calvet, Marc; Molinuevo, José Luis; ALFA Study (BioMed Central, 2021)
    Background: Understanding the changes that occur in the transitional stage between absent and overt amyloid-β (Aβ) pathology within the Alzheimer's continuum is crucial to develop therapeutic and preventive strategies. The ...
  • Milà Alomà, Marta; Brinkmalm, Ann; Ashton, Nicholas J.; Kvartsberg, Hlin; Shekari, Mahnaz; Operto, Grégory; Salvadó, Gemma; Falcon, Carles; Domingo Gispert, Juan; Vilor Tejedor, Natàlia, 1988-; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Sala Vila, Aleix; Sanchez-Benavides, Gonzalo; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Niñerola-Baizán, Aida; Perissinotti, Andrés; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Zetterberg, Henrik; Molinuevo, José Luis; Blennow, Kaj; Suárez-Calvet, Marc; ALFA Study (Lippincott Williams & Wilkins, 2021)
    Background and objectives: To determine whether CSF synaptic biomarkers are altered in the early preclinical stage of the Alzheimer continuum and associated with Alzheimer disease (AD) risk factors, primary pathology, and ...
  • Benedet, Andrea L.; Milà Alomà, Marta; Salvadó, Gemma; Shekari, Mahnaz; Operto, Gregory; Gispert López, Juan Domingo; Minguillón, Carolina; Molinuevo, José Luis; Suárez-Calvet, Marc; Translational Biomarkers in Aging and Dementia (TRIAD) study; ALFA Study; BioCogBank Paris Lariboisière cohort (American Medical Association, 2021)
    Importance: Glial fibrillary acidic protein (GFAP) is a marker of reactive astrogliosis that increases in the cerebrospinal fluid (CSF) and blood of individuals with Alzheimer disease (AD). However, it is not known whether ...
  • Stankeviciute, Laura; Falcón, Carles; Operto, Grégory; Garcia, Marina; Shekari, Mahnaz; Iranzo, Alex; Niñerola-Baizán, Aida; Perissinotti, Andrés; Minguillón, Carolina; Fauria, Karine; Molinuevo, José Luis; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Cacciaglia, Raffaele; Gispert López, Juan Domingo; Grau-Rivera, Oriol; ALFA Study (Wiley, 2023)
    Introduction: Poor sleep quality is associated with cognitive outcomes in Alzheimer's disease (AD). We analyzed the associations between self-reported sleep quality and brain structure and function in cognitively unimpaired ...
  • Suárez-Calvet, Marc; Milà Alomà, Marta; Gispert López, Juan Domingo; Salvadó, Gemma; Minguillón, Carolina; Shekari, Mahnaz; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; Sala Vila, Aleix; González de Echávarri, José Maria; Molinuevo, José Luis; ALFA Study (Wiley, 2020)
    In Alzheimer's disease (AD), tau phosphorylation in the brain and its subsequent release into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease evolution. The main aim of our study was ...
  • Lantero Rodriguez, Juan; Snellman, Anniina; Benedet, Andrea L.; Milà Alomà, Marta; Camporesi, Elena; Montoliu-Gaya, Laia; Ashton, Nicholas J.; Vrillon, Agathe; Karikari, Thomas K.; Domingo Gispert, Juan; Salvadó, Gemma; Shekari, Mahnaz; Toomey, Christina E.; Lashley, Tammaryn L.; Zetterberg, Henrik; Suárez-Calvet, Marc; Brinkmalm, Gunnar; Rosa-Neto, Pedro; Blennow, Kaj (Wiley, 2021)
    Alzheimer's disease (AD) is characterised by a long preclinical phase. Although phosphorylated tau (p-tau) species such as p-tau217 and p-tau231 provide accurate detection of early pathological changes, other biomarkers ...
  • Vilor Tejedor, Natàlia, 1988-; Ciampa, Iacopo; Operto, Grégory; Falcón, Carles; Suárez-Calvet, Marc; Crous-Bou, Marta; Shekari, Mahnaz; Arenaza Urquijo, Eider M.; Milà Alomà, Marta; Grau-Rivera, Oriol; Minguillón, Carolina; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Guigó Serra, Roderic; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (BioMed Central, 2021)
    Background: Perivascular spaces (PVS) have an important role in the elimination of metabolic waste from the brain. It has been hypothesized that the enlargement of PVS (ePVS) could be affected by pathophysiological mechanisms ...
  • Milà Alomà, Marta; Shekari, Mahnaz; Salvadó, Gemma; Ortiz Romero, Paula, 1994-; González-Escalante, Armand; Sánchez Benavides, Gonzalo; Minguillón, Carolina; Gispert López, Juan Domingo; Suárez-Calvet, Marc; Blennow, Kaj (Nature Research, 2022)
    Blood biomarkers indicating elevated amyloid-β (Aβ) pathology in preclinical Alzheimer's disease are needed to facilitate the initial screening process of participants in disease-modifying trials. Previous biofluid data ...
  • Collij, Lyduine E.; Salvadó, Gemma; de Wilde, Arno; Altomare, Daniele; Shekari, Mahnaz; Domingo Gispert, Juan; Bullich, Santiago; Stephens, Andrew W.; Barkhof, Frederik; Scheltens, Philip; Bouwman, Femke; van der Flier, Wiesje M. (Wiley, 2022)
    Introduction: we investigated amyloid-burden quantification in a mixed memory clinic population. Methods: [18 F]Florbetaben amyloid-PET (positron emission tomography) scans of 348 patients were visually read and quantified ...
  • Pemberton, Hugh G.; Collij, Lyduine E.; Heeman, Fiona; Bollack, Ariane; Shekari, Mahnaz; Salvadó, Gemma; Lopes Alves, Isadora; Vallez Garcia, David; Battle, Mark; Buckley, Christopher, 1948-; Stephens, Andrew W.; Bullich, Santiago; Garibotto, Valentina; Barkhof, Frederik; Gispert López, Juan Domingo; Farrar, Gill; AMYPAD Consortium (Springer, 2022)
    Amyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer's disease (AD) pathogenesis. The overall load and spatial distribution of brain Aβ can be determined in vivo using positron emission ...
  • Salvadó, Gemma; Milà Alomà, Marta; Shekari, Mahnaz; Operto, Grégory; Falcón, Carles; Cacciaglia, Raffaele; Minguillón, Carolina; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Gispert López, Juan Domingo; ALFA Study (SpringerOpen, 2022)
    Purpose: glial activation is one of the earliest mechanisms to be altered in Alzheimer's disease (AD). Glial fibrillary acidic protein (GFAP) relates to reactive astrogliosis and can be measured in both cerebrospinal fluid ...
  • Akinci, Muge; Sánchez Benavides, Gonzalo; Brugulat Serrat, Anna, 1986-; Peña-Gómez, Cleofé; Palpatzis, Eleni; Shekari, Mahnaz; Deulofeu, Carme; Fuentes-Julian, Sherezade; Salvadó, Gemma; González de Echávarri, José Maria; Suárez-Calvet, Marc; Minguillón, Carolina; Fauria, Karine; Molinuevo, José Luis; Domingo Gispert, Juan; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; ALFA Study (BioMed Central, 2022)
    Background: the COVID-19 pandemic may worsen the mental health of people reporting subjective cognitive decline (SCD) and therefore their clinical prognosis. We aimed to investigate the association between the intensity ...
  • Collij, Lyduine E.; Salvadó, Gemma; Shekari, Mahnaz; Lopes Alves, Isadora; Reimand, Juhan; Wink, Alle-Meije; Zwan, Marissa; Niñerola-Baizán, Aida; Perissinotti, Andrés; Scheltens, Philip; Ikonomovic, Milos D.; Smith, Adrian P.L.; Farrar, Gill; Molinuevo, José Luis; Barkhof, Frederik; Buckley, Christopher, 1948-; van Berckel, Bart N. M. (Springer, 2021)
    Purpose: To investigate the sensitivity of visual read (VR) to detect early amyloid pathology and the overall utility of regional VR. Methods: [18F]Flutemetamol PET images of 497 subjects (ALFA+ N = 352; ADC N = 145) were ...

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