Browsing by Author "Sestan, Nenad"

Sort by: Order: Results:

  • Differential Gene Expression in the Human Brain Is Associated with Conserved, but Not Accelerated, Noncoding Sequences
    Meyer, Kyle A.; Marquès i Bonet, Tomàs, 1975-; Sestan, Nenad (Oxford University Press, 2017)
    Previous studies have found that genes which are differentially expressed within the developing human brain disproportionately neighbor conserved noncoding sequences (CNSs) that have an elevated substitution rate in humans ...
  • Molecular and cellular reorganization of neural circuits in the human lineage
    Sousa, André M. M.; Zhu, Ying; Raghanti, Mary Ann; Kitchen, Robert R.; Onorati, Marco; Tebbenkamp, Andrew T. N.; Stutz, Bernardo; Meyer, Kyle A.; Li, Mingfeng; Kawasawa, Yuka Imamura; Liu, Fuchen; García Pérez, Raquel, 1989-; Mele, Marta; Carvalho, Tiago Loureiro de, 1987-; Skarica, Mario; Gulden, Forrest O.; Pletikos, Mihovil; Shibata, Akemi; Stephenson, Alexa R.; Edler, Melissa K.; Ely, John J.; Elsworth, John D.; Horvath, Tamas L.; Hof, Patrick R.; Hyde, Thomas M.; Kleinman, Joel E.; Weinberger, Daniel R.; Reimers, Mark; Lifton, Richard P.; Mane, Shrikant M.; Noonan, James P.; State, Matthew W.; Lein, Ed S.; Knowles, James A.; Marquès i Bonet, Tomàs, 1975-; Sherwood, Chet C.; Gerstein, Mark B.; Sestan, Nenad (American Association for the Advancement of Science (AAAS), 2017)
    To better understand the molecular and cellular differences in brain organization between human and nonhuman primates, we performed transcriptome sequencing of 16 regions of adult human, chimpanzee, and macaque brains. ...
  • Spatiotemporal transcriptomic divergence across human and macaque brain development
    Zhu, Ying; Sousa, André M. M.; Gao, Tianliuyun; Skarica, Mario; Li, Mingfeng; Santpere Baró, Gabriel, 1981-; Esteller Cucala, Paula; Juan, David; Ferrández Peral, Luis, 1991-; Gulden, Forrest O.; Yang, Mo; Miller, Daniel J.; Marquès i Bonet, Tomàs, 1975-; Kawasawa, Yuka Imamura; Zhao, Hongyu; Sestan, Nenad (American Association for the Advancement of Science (AAAS), 2018)
    Human nervous system development is an intricate and protracted process that requires precise spatiotemporal transcriptional regulation. We generated tissue-level and single-cell transcriptomic data from up to 16 brain ...
  • Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells
    Franjic, Daniel; Santpere Baró, Gabriel, 1981-; Sestan, Nenad (Elsevier, 2022)
    The hippocampal-entorhinal system supports cognitive functions, has lifelong neurogenic capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To investigate neurogenic potential and cellular ...
  • Whole-genome and RNA sequencing reveal variation and transcriptomic coordination in the developing human prefrontal cortex
    Werling, Donna M.; Santpere Baró, Gabriel, 1981-; Sestan, Nenad (Elsevier, 2020)
    Gene expression levels vary across developmental stage, cell type, and region in the brain. Genomic variants also contribute to the variation in expression, and some neuropsychiatric disorder loci may exert their effects ...