Browsing by Author "Serrano, Manuel"

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  • Christou-Kent, Marie; Cuartero, Sergi; Garcia-Cabau, Carla; Ruehle, Julia; Naderi, Julian; Erber, Julia; Neguembor, Maria Victoria; Plana Carmona, Marcos, 1993-; Alcoverro-Bertran, Marc; Andrés Aguayo, Luisa de; Klonizakis, Antonios; Julià Vilella, Eric; Lynch, Cian J.; Serrano, Manuel; Hnisz, Denes; Salvatella, Xavier; Graf, T. (Thomas); Stik, Grégoire (Elsevier, 2023)
    Cell identity is orchestrated through an interplay between transcription factor (TF) action and genome architecture. The mechanisms used by TFs to shape three-dimensional (3D) genome organization remain incompletely ...
  • Chondronasiou, Dafni; Martínez de Villarreal, Jaime; Melendez, Elena; Lynch, Cian J.; Pozo, Natalia del; Kovatcheva, Marta; Aguilera, Mònica; Prats, Neus; Real, Francisco X.; Serrano, Manuel (Elsevier, 2022)
    Differentiated cells can be converted into pluripotent stem cells by expressing the transcription factors OCT4, SOX2, KLF4, and MYC (OSKM) in a process known as reprogramming. Here, using single-cell RNA sequencing of ...
  • Arc-Chagnaud, Coralie; Salvador-Pascual, Andrea; Garcia-Dominguez, Esther; Olaso-Gonzalez, Gloria; Correas, Angela G.; Serna, Eva; Brioche, Thomas; Chopard, Angele; Fernandez-Marcos, Pablo J.; Serrano, Manuel; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962-; Sebastiá, Vicente; Viña, Jose; Gomez-Cabrera, Mari Carmen (Wiley, 2021)
    Background: Frailty is a major age-associated syndrome leading to disability. Oxidative damage plays a significant role in the promotion of frailty. The cellular antioxidant system relies on reduced nicotinamide adenine ...
  • Domínguez-López, Inés; Kovatcheva, Marta; Casas, Rosa; Toledo, Estefania; Fitó Colomer, Montserrat; Ros, Emilio; Estruch, Ramón; Serrano, Manuel; Lamuela-Raventós, Rosa M. (Wiley, 2024)
    Background: Vitamin B12 is an essential nutrient that is involved in numerous physiological processes, and its deficiency can lead to various complications, including neurological and haematological disorders. Some studies ...
  • Ruiz, Sergio; Lopez Contreras, Andres J.; Gabut, Mathieu; Marion, Rosa M.; Gutiérrez Martínez, Paula; Bua, Sabela; Ramírez, Oscar; Olalde Marquínez, Íñigo, 1987-; Rodrigo Perez, Sara; Li, Han; Marquès i Bonet, Tomàs, 1975-; Serrano, Manuel; Blasco, Maria A.; Batada, Nizar N.; Fernández Capetillo, Oscar (Nature Publishing Group, 2015)
    The generation of induced pluripotent stem cells (iPSC) from adult somatic cells is one of the most remarkable discoveries in recent decades. However, several works have reported evidence of genomic instability in iPSC, ...
  • Melendez, Elena; Chondronasiou, Dafni; Mosteiro, Lluc; Martínez de Villarreal, Jaime; Fernández-Alfara, Marcos; Lynch, Cian J.; Grimm, Dirk; Real, Francisco X.; Alcamí, José; Climent, Núria; Pietrocola, Federico; Serrano, Manuel (Company of Biologists, 2022)
    The ectopic expression of the transcription factors OCT4, SOX2, KLF4 and MYC (OSKM) enables reprogramming of differentiated cells into pluripotent embryonic stem cells. Methods based on partial and reversible in vivo ...
  • Martínez de Villarreal, Jaime; Kalisz, Mark; Piedrafita, Gabriel; Graña-Castro, Osvaldo; Chondronasiou, Dafni; Serrano, Manuel; Real, Francisco X. (Oxford University Press, 2023)
    Transposable elements (TE) have played a major role in configuring the structures of mammalian genomes through evolution. In normal conditions, the expression of these elements is repressed by different epigenetic regulation ...
  • Plana-Carmona, Marcos; Stik, Grégoire; Bulteau, Romain; Segura-Morales, Carolina; Alcázar, Noelia; Wyatt, Christopher Douglas Robert, 1988-; Klonizakis, Antonios; Andrés Aguayo, Luisa de; Gasnier, Maxime; Tian, Tian V.; Torcal Garcia, Guillem, 1991-; Vila-Casadesús, Maria; Plachta, Nicolas; Serrano, Manuel; Francesconi, Mirko; Graf, T. (Thomas) (Elsevier, 2022)
    IL-6 has been shown to be required for somatic cell reprogramming into induced pluripotent stem cells (iPSCs). However, how Il6 expression is regulated and whether it plays a role during embryo development remains unknown. ...
  • Vilas, Jéssica M.; Ferreirós, Alba; Carneiro, Carmen; Morey Ramonell, Lluís; Silva-Álvarez, Sabela da; Fernandes, Tânia; Abad, María; Di Croce, Luciano; García Caballero, Tomás; Serrano, Manuel; Rivas, Carmen; Vidal, Anxo; Collado, Manuel (Impact Journals, 2015)
    Cellular reprogramming to iPSCs has uncovered unsuspected links between tumor suppressors and pluripotency factors. Using this system, it was possible to identify tumor suppressor p27 as a repressor of Sox2 during ...
  • Guerra, Carmen; Mijimolle, Nieves; Dhawahir, Alma; Dubus, Pierre; Barradas, Marta; Serrano, Manuel; Campuzano Uceda, María Victoria; Barbacid, Mariano (Elsevier, 2003)
    We have targeted a K-ras allele in mouse embryonic stem (ES) cells to express a K-Ras(V12) oncoprotein along with a marker protein (beta-geo) from a single bicistronic transcript. Expression of this oncogenic allele requires ...

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