Browsing by Author "Serrano, Antonio L."

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  • Mann, Christopher J.; Perdiguero, Eusebio, 1968-; Kharraz, Yacine; Aguilar, Susana; Pessina, Patrizia; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2011)
    The repair process of damaged tissue involves the coordinated activities of several cell types in response to local and systemic signals. Following acute tissue injury, infiltrating inflammatory cells and resident stem ...
  • Vidal Iglesias, Berta; Ardite, Esther; Suelves, Mònica; Ruiz Bonilla, Vanesa, 1979-; Janué, Anna; Flick, Matthew J.; Degen, Jay L.; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Oxford University Press, 2012)
    In Duchenne muscular dystrophy (DMD), a persistently altered and reorganizing extracellular matrix (ECM) within inflamed muscle promotes damage and dysfunction. However, the molecular determinants of the ECM that mediate ...
  • Sala, David; Ivanova, Saska; Plana, Natàlia; Ribas, Vicent; Duran, Jordi; Bach, Daniel; Turkseven, Saadet; Laville, Martine; Vidal, Hubert; Karczewska-Kupczewska, Monika; Kowalska, Irina; Straczkowski, Marek; Testar, Xavier; Palacín Mateo, Manuel; Sandri, Marco; Serrano, Antonio L.; Zorzano, Antonio (American Society for Clinical Investigation, 2014)
    A precise balance between protein degradation and synthesis is essential to preserve skeletal muscle mass. Here, we found that TP53INP2, a homolog of the Drosophila melanogaster DOR protein that regulates autophagy in ...
  • Perdiguero, Eusebio, 1968-; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Elsevier, 2017)
    Fibro/adipogenic progenitors (FAPs) are emerging as crucial regulators of fibrous and fat deposits during skeletal muscle regeneration. In a recent issue of Cell, Kopinke et al. (2017) report that primary cilia induce the ...
  • Pessina, Patrizia; Kharraz, Yacine; Jardí, Mercè; Fukada, So-ichiro; Serrano, Antonio L.; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (Elsevier, 2015)
    Preservation of cell identity is necessary for homeostasis of most adult tissues. This process is challenged every time a tissue undergoes regeneration after stress or injury. In the lethal Duchenne muscular dystrophy ...
  • Arc-Chagnaud, Coralie; Salvador-Pascual, Andrea; Garcia-Dominguez, Esther; Olaso-Gonzalez, Gloria; Correas, Angela G.; Serna, Eva; Brioche, Thomas; Chopard, Angele; Fernandez-Marcos, Pablo J.; Serrano, Manuel; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962-; Sebastiá, Vicente; Viña, Jose; Gomez-Cabrera, Mari Carmen (Wiley, 2021)
    Background: Frailty is a major age-associated syndrome leading to disability. Oxidative damage plays a significant role in the promotion of frailty. The cellular antioxidant system relies on reduced nicotinamide adenine ...
  • Muñoz Cánoves, Pura, 1962-; Scheele, Camilla; Pedersen, Bente K.; Serrano, Antonio L. (Wiley, 2013)
    Interleukin (IL)-6 is a cytokine with pleiotropic functions in different tissues and organs. Skeletal muscle produces and releases significant levels of IL-6 after prolonged exercise and is therefore considered as a myokine. ...
  • Testoni, Giorgia; Duran, Jordi; García-Rocha, Mar; Vilaplana, Francisco; Serrano, Antonio L.; Sebastián, David; López Soldado, Iliana; Sullivan, Mitchell A.; Slebe Concha, Juan Felipe, 1981-; Vilaseca, Marta; Muñoz Cánoves, Pura, 1962-; Guinovart, Joan J. (Joan Josep), 1947- (Elsevier, 2017)
    Glycogenin is considered essential for glycogen synthesis, as it acts as a primer for the initiation of the polysaccharide chain. Against expectations, glycogenin-deficient mice (Gyg KO) accumulate high amounts of glycogen ...
  • Kharraz, Yacine; Guerra, Joan; Mann, Christopher J.; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Hindawi, 2013)
    Effective repair of damaged tissues and organs requires the coordinated action of several cell types, including infiltrating inflammatory cells and resident cells. Recent findings have uncovered a central role for macrophages ...
  • Pessina, Patrizia; Cabrera, Daniel; Morales, María Gabriela; Riquelme, Cecilia A; Gutiérrez, Jaime; Serrano, Antonio L.; Brandan, Enrique; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2014)
    Background: Fibrosis, an excessive collagen accumulation, results in scar formation, impairing function of vital organs and tissues. Fibrosis is a hallmark of muscular dystrophies, including the lethal Duchenne muscular ...
  • Perdiguero, Eusebio, 1968-; Sousa-Victor, Pedro; Ruiz Bonilla, Vanesa, 1979-; Jardí, Mercè; Caelles Franch, Carme; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Rockefeller University Press, 2011)
    Repair of damaged tissue requires the coordinated action of inflammatory and tissue-specific cells to restore homeostasis, but the underlying regulatory mechanisms are poorly understood. In this paper, we report new roles ...
  • Ardite, Esther; Perdiguero, Eusebio, 1968-; Vidal Iglesias, Berta; Gutarra, Susana; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Rockefeller University Press, 2012)
    There is a widespread awareness that the wealth of preclinical toxicity data that the pharmaceutical industry has generated in recent decades is not exploited as efficiently as it could be. Enhanced data availability for ...
  • Bengal, Eyal; Perdiguero, Eusebio, 1968-; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (F1000Research, 2017)
    Adult muscle stem cells, originally called satellite cells, are essential for muscle repair and regeneration throughout life. Besides a gradual loss of mass and function, muscle aging is characterized by a decline in the ...
  • Guerrero, Lucia; Marco Ferreres, Raquel; Serrano, Antonio L.; Arredondo, Juan Jose; Cervera, Margarita (Elsevier, 2010)
    Although tight quantitative control of gene expression is required to ensure that organs and tissues function correctly, the transcriptional mechanisms underlying this process still remain poorly understood. Here, we ...
  • Segalés Dalmau, Jessica; Perdiguero, Eusebio, 1968-; Serrano, Antonio L.; Sousa-Victor, Pedro; Ortet Cortada, Laura; Jardí, Mercè; Budanov, Andrei V.; García-Prat, Laura, 1987-; Sandri, Marco; Thomson, David M.; Karin, Michael; Hee Lee, Jun; Muñoz Cánoves, Pura, 1962- (Nature Research, 2020)
    A unique property of skeletal muscle is its ability to adapt its mass to changes in activity. Inactivity, as in disuse or aging, causes atrophy, the loss of muscle mass and strength, leading to physical incapacity and poor ...
  • Kharraz, Yacine; Guerra, Joana; Pessina, Patrizia; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Hindawi, 2014)
    Fibrosis is the aberrant deposition of extracellular matrix (ECM) components during tissue healing leading to loss of its architecture and function. Fibrotic diseases are often associated with chronic pathologies and occur ...

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