Browsing by Author "Serra Pascual, Selma A., 1981-"

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  • A Single Amino Acid Deletion (ΔF1502) in the S6 Segment of CaV2.1 Domain III Associated with Congenital Ataxia Increases Channel Activity and Promotes Ca2+ Influx
    Bahamonde Santos, María Isabel, 1972-; Serra Pascual, Selma A., 1981-; Drechsel, Oliver; Rahman, Rubayte; Marcé-Grau, Anna; Prieto, Marta; Ossowski, Stephan; Macaya, Alfons; Fernández-Fernández, José Manuel, 1967- (Public Library of Science (PLoS), 2015)
    Mutations in the CACNA1A gene, encoding the pore-forming CaV2.1 (P/Q-type) channel α1A subunit, result in heterogeneous human neurological disorders, including familial and sporadic hemiplegic migraine along with episodic ...
  • Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area
    Zhao, Runchen; Afthinos, Alexandros; Zhu, Tian; Mistriotis, Panagiotis; Li, Yizeng; Serra Pascual, Selma A., 1981-; Zhang, Yuqi; Yankaskas, Christopher L.; He, Shuyu; Valverde, M. A. (Miguel Ángel), 1963-; Sun, Sean X.; Konstantopoulos, Konstantinos (American Association for the Advancement of Science (AAAS), 2019)
    How cells sense hydraulic pressure and make directional choices in confinement remains elusive. Using trifurcating Ψ-like microchannels of different hydraulic resistances and cross-sectional areas, we discovered that the ...
  • Confinement sensing and signal optimization via Piezo1/PKA and myosin II pathways
    Hung, Wei-Chien; Yang, Jessica R.; Yankaskas, Christopher L.; Wong, Bin Sheng; Wu, Pei-Hsun; Pardo Pastor, Carlos; Serra Pascual, Selma A., 1981-; Chiang, Meng-Jung; Gu, Zhizhan; Wirtz, Denis; Valverde, M. A. (Miguel Ángel), 1963-; Zhang, Jin; Konstantopoulos, Konstantinos (Elsevier, 2016)
    Cells adopt distinct signaling pathways to optimize cell locomotion in different physical microenvironments. However, the underlying mechanism that enables cells to sense and respond to physical confinement is unknown. ...
  • Cross talk between β subunits, intracellular Ca2+ signaling, and SNAREs in the modulation of CaV 2.1 channel steady-state inactivation
    Serra Pascual, Selma A., 1981-; Gené, Gemma; Elorza Vidal, Xabier; Fernández-Fernández, José Manuel, 1967- (Wiley, 2018)
    Modulation of CaV 2.1 channel activity plays a key role in interneuronal communication and synaptic plasticity. SNAREs interact with a specific synprint site at the second intracellular loop (LII-III) of the CaV 2.1 ...
  • IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid
    Fernandes, Jacqueline; Lorenzo, Ivan M.; Andrade, Yaniré N.; Garcia-Elias Heras, Anna; Serra Pascual, Selma A., 1981-; Fernández-Fernández, José Manuel, 1967-; Valverde, M. A. (Miguel Ángel), 1963- (Rockefeller University Press, 2008)
    Mechanical and osmotic sensitivity of the transient receptor potential vanilloid 4 (TRPV4) channel depends on phospholipase A(2) (PLA(2)) activation and the subsequent production of the arachidonic acid metabolites, ...
  • Murine ES-derived pancreatic acinar cells recapitulate features of early pancreatic differentiation
    Rovira Clusellas, Meritxell; Delaspre, Fabien; Massumi, Mohammad; Serra Pascual, Selma A., 1981-; Valverde, M. A. (Miguel Ángel), 1963-; Lloreta Trull, Josep, 1958-; Dufresne, Marlène; Payré, Bruno; Konieczny, Stephen F.; Savatier, Pierre; Real, Francisco X.; Skoudy, Anouchka (Elsevier, 2008)
    Background & Aims: Acinar cells constitute 90% of the pancreas epithelium, are polarized, and secrete digestive enzymes. These cells play a crucial role in pancreatitis and pancreatic cancer. However, there are limited ...
  • Screening of CACNA1A and ATP1A2 genes in hemiplegic migraine: clinical, genetic, and functional studies
    Carreño, Oriel; Corominas, Roser; Serra Pascual, Selma A., 1981-; Sintas, Cèlia; Fernández Castillo, Noelia; Vila Pueyo, Marta; Toma, Claudio; Gené, Gemma; Pons, Roser; Llaneza, Miguel; Sobrido, María Jesús; Grinberg, Daniel; Valverde, M. A. (Miguel Ángel), 1963-; Fernández-Fernández, José Manuel, 1967-; Macaya, Alfons; Cormand, Bru (Wiley, 2013)
    Hemiplegic migraine (HM) is a rare and severe subtype of autosomal dominant migraine, characterized by a complex aura including some degree of motor weakness. Mutations in four genes (CACNA1A, ATP1A2, SCN1A and PRRT2) have ...
  • Structural determinants of 5′,6′-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel
    Berna Erro, Alejandro; Izquierdo Serra, Mercè; Sepúlveda, Romina V.; Rubio Moscardó, Fanny; Doñate-Macián, Pau; Serra Pascual, Selma A., 1981-; Carrillo García, Julia, 1993-; Perálvarez Marín, Alex; González Nilo, Fernando; Fernández-Fernández, José Manuel, 1967-; Valverde, M. A. (Miguel Ángel), 1963- (Nature Publishing Group, 2017)
    TRPV4 cation channel activation by cytochrome P450-mediated derivatives of arachidonic acid (AA), epoxyeicosatrienoic acids (EETs), constitute a major mechanisms of endothelium-derived vasodilatation. Besides, TRPV4 ...