Browsing by Author "Segarra-Queralt, Maria"

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Mechano-biochemical systems modelling for patient stratification in osteoarthritis

Segarra-Queralt, Maria (Universitat Pompeu Fabra, 2023-12-04)

This doctoral thesis presents two different computational approaches to explore mechanistically chondrocyte dysregulation and identify biomarkers, to better understand patient stratification systems in primary knee ...
Network-based modelling of mechano-inflammatory chondrocyte regulation in early osteoarthritis

Segarra-Queralt, Maria; Piella Fenoy, Gemma; Noailly, Jérôme (Frontiers, 2023)

Osteoarthritis (OA) is a debilitating joint disease characterized by articular cartilage degradation, inflammation and pain. An extensive range of in vivo and in vitro studies evidences that mechanical loads induce changes ...
Regulatory network-based model to simulate the biochemical regulation of chondrocytes in healthy and osteoarthritic environments

Segarra-Queralt, Maria; Neidlin, Michael; Tió, Laura; Monfort, Jordi; Monllau García, Juan Carlos; González Ballester, Miguel Ángel, 1973-; Alexopoulos, Leonidas G.; Piella Fenoy, Gemma; Noailly, Jérôme (Nature Research, 2022)

In osteoarthritis (OA), chondrocyte metabolism dysregulation increases relative catabolic activity, which leads to cartilage degradation. To enable the semiquantitative interpretation of the intricate mechanisms of OA ...

Now showing items 1-3 of 3

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