Browsing by Author "Segalés Dalmau, Jessica"

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  • Brain-muscle communication prevents muscle aging by maintaining daily physiology
    Kumar, Arun; Vaca Dempere, Mireia, 1994-; Mortimer, Thomas; Deryagin, Oleg; Smith, Jacob G.; Petrus, Paul; Koronowski, Kevin B.; Greco, Carolina M.; Segalés Dalmau, Jessica; Andrés, Eva; Lukesova, Vera; Zinna, Valentina M.; Welz, Patrick-Simon; Serrano Sánchez, Antonio L.; Perdiguero, Eusebio, 1968-; Sassone-Corsi, Paolo; Aznar Benitah, Salvador; Muñoz Cánoves, Pura, 1962- (American Association for the Advancement of Science (AAAS), 2024)
    A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In arrhythmic mice showing ...
  • CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration
    Sreenivasan, Krishnamoorthy; Rodríguez de la Rosa, Alejandra; Kim, Johnny; Mesquita, Diana; Segalés Dalmau, Jessica; Gómez del Arco, Pablo; Espejo, Isabel; Ianni, Alessandro; Di Croce, Luciano; Relaix, Frederic; Redondo, Juan Miguel; Braun, Thomas; Serrano Sánchez, Antonio L.; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (Elsevier, 2021)
    Regeneration of skeletal muscle requires resident stem cells called satellite cells. Here, we report that the chromatin remodeler CHD4, a member of the nucleosome remodeling and deacetylase (NuRD) repressive complex, is ...
  • Chromatin-wide and transcriptome profiling integration uncovers p38α MAPK as a global regulator of skeletal muscle differentiation
    Segalés Dalmau, Jessica; Islam, Abul, 1978-; Kumar, Roshan; Liu, Qi-Cai; Sousa-Victor, Pedro; Dilworth, F. Jeffrey; Ballestar, Esteban; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2016)
    Background: Extracellular stimuli induce gene expression responses through intracellular signaling mediators. The p38 signaling pathway is a paradigm of the mitogen-activated protein kinase (MAPK) family that, although ...
  • Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy
    Hong, Xiaotong; Isern, Joan; Campanario, Silvia; Perdiguero, Eusebio, 1968-; Ramírez Pardo, Ignacio; Segalés Dalmau, Jessica; Hernansanz-Agustín, Pablo; Curtabbi, Andrea; Deryagin, Oleg; Pollán, Angela; González-Reyes, José A.; Villalba, José M.; Sandri, Marco; Serrano Sánchez, Antonio L.; Enríquez, José Antonio; Muñoz Cánoves, Pura, 1962- (Elsevier, 2022)
    Skeletal muscle regeneration depends on the correct expansion of resident quiescent stem cells (satellite cells), a process that becomes less efficient with aging. Here, we show that mitochondrial dynamics are essential ...
  • Regulation of muscle stem cell functions: a focus on the p38 MAPK signaling pathway
    Segalés Dalmau, Jessica; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (Frontiers, 2016)
    Formation of skeletal muscle fibers (myogenesis) during development and after tissue injury in the adult constitutes an excellent paradigm to investigate the mechanisms whereby environmental cues control gene expression ...
  • Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration
    Moiseeva, Victoria, 1992-; Cisneros, Andrés; Sica, Valentina; Deryagin, Oleg; Andrés, Eva; Segalés Dalmau, Jessica; Ortet Cortada, Laura; Lukesova, Vera; Serrano Sánchez, Antonio L.; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (Nature Research, 2023)
    Tissue regeneration requires coordination between resident stem cells and local niche cells1,2. Here we identify that senescent cells are integral components of the skeletal muscle regenerative niche that repress regeneration ...
  • Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals
    Segalés Dalmau, Jessica; Perdiguero, Eusebio, 1968-; Serrano, Antonio L.; Sousa-Victor, Pedro; Ortet Cortada, Laura; Jardí, Mercè; Budanov, Andrei V.; García-Prat, Laura, 1987-; Sandri, Marco; Thomson, David M.; Karin, Michael; Hee Lee, Jun; Muñoz Cánoves, Pura, 1962- (Nature Research, 2020)
    A unique property of skeletal muscle is its ability to adapt its mass to changes in activity. Inactivity, as in disuse or aging, causes atrophy, the loss of muscle mass and strength, leading to physical incapacity and poor ...
  • The dystrophin glycoprotein complex regulates the epigenetic activation of muscle stem cell commitment
    Chang, Natasha C.; Sincennes, Marie-Claude; Chevalier, Fabien P.; Brun, Caroline E.; Lacaria, Melanie; Segalés Dalmau, Jessica; Muñoz Cánoves, Pura, 1962-; Ming, Hong; Rudnicki, Michael A. (Elsevier, 2018)
    Asymmetrically dividing muscle stem cells in skeletal muscle give rise to committed cells, where the myogenic determination factor Myf5 is transcriptionally activated by Pax7. This activation is dependent on Carm1, which ...

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