Browsing by Author "Sdelci, Sara"

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  • Moretton, Amandine; Kourtis, Savvas; Gañez-Zapater, Antoni; Calabrò, Chiara; Espinar Calvo, Maria Lorena; Fontaine, Frédéric; Darai, Evangelia; Abad Cortel, Etna; Block, Samuel; Pascual-Reguant, Laura, 1990-; Pardo-Lorente, Natalia; Ghose, Ritobrata; Vander Heiden, Matthew G.; Janic, Ana; Müller, André C.; Loizou, Joanna I.; Sdelci, Sara (EMBO Press, 2023)
    While cellular metabolism impacts the DNA damage response, a systematic understanding of the metabolic requirements that are crucial for DNA damage repair has yet to be achieved. Here, we investigate the metabolic enzymes ...
  • Ghose, Ritobrata (Universitat Pompeu Fabra, 2024-03-22)
    Cancer cells are constantly subject to complex stresses in the tumour microenvironment. These stresses encapsulate a wide array of challenging stimuli from physical and mechanical forces to interference in major mechanistic ...
  • Pardo Lorente, Natalia (Universitat Pompeu Fabra, 2023-10-17)
    Subcellular compartmentalisation of metabolic enzymes may elicit specific cellular functions by establishing a unique metabolic environment. Indeed, the nuclear translocation of certain metabolic enzymes impacts epigenetics ...
  • Pascual-Reguant, Laura; Datta, Debayan; Cianferoni, Damiano; Kourtis, Savvas; Gañez-Zapater, Antoni; Cannatá, Chiara; Espinar, Lorena; García López, Laura; Musa-Afaneh, Sara; Guirola, Maria; Gkanogiannis, Anestis; Miró Canturri, Andrea; Arribas, Joaquín; Serrano Pubull, Luis, 1982-; Sdelci, Sara (EMBO Press, 2023)
    Triple-negative breast cancer (TNBC) often develops resistance to single-agent treatment, which can be circumvented using targeted combinatorial approaches. Here, we demonstrate that the simultaneous inhibition of LOXL2 ...

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