Browsing by Author "Schlesner, Matthias"

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  • Sieverling, Lina; Hong, Chen; Koser, Sandra D.; Ginsbach, Philip; Kleinheinz, Kortine; Hutter, Barbara; Braun, Delia M.; Cortés-Ciriano, Isidro; Xi, Ruibin; Kabbe, Rolf; Park, Peter J.; Eils, Roland; Schlesner, Matthias; PCAWG Structural Variation Working Group; Brors, Benedikt; Rippe, Karsten; Jones, David T. W.; Feuerbach, Lars; PCAWG Consortium; Ossowski, Stephan; Estivill, Xavier, 1955- (Nature Research, 2020)
    Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ...
  • Tirier, Stephan M.; Park, Jeongbin; Preußer, Friedrich; Amrhein, Lisa; Gu, Zuguang; Steiger, Simon; Mallm, Jan-Philipp; Krieger, Teresa; Waschow, Marcel; Eismann, Björn; Gut, Marta; Gut, Ivo Glynne; Rippe, Karsten; Schlesner, Matthias; Theis, Fabian; Fuchs, Christiane; Ball, Claudia R.; Glimm, Hanno; Eils, Roland; Conrad, Christian (Nature Research, 2019)
    Patient-derived 3D cell culture systems are currently advancing cancer research since they potentiate the molecular analysis of tissue-like properties and drug response under well-defined conditions. However, our understanding ...
  • Blanco-Carmona, Enrique; Narayanan, Ashwin; Hernandez, Inmaculada; Nieto, Juan C.; Elosua-Bayés, Marc; Sun, Xueyuan; Schmidt, Claudia; Pamir, Necmettin; Özduman, Koray; Herold-Mende, Christel; Pagani, Francesca; Cominelli, Manuela; Taranda, Julian; Wick, Wolfgang; von Deimling, Andreas; Poliani, Pietro Luigi; Rehli, Michael; Schlesner, Matthias; Heyn, Holger; Turcan, Sevin (Elsevier, 2023)
    The isocitrate dehydrogenase (IDH) gene is recurrently mutated in adult diffuse gliomas. IDH-mutant gliomas are categorized into oligodendrogliomas and astrocytomas, each with unique pathological features. Here, we use ...

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