Browsing by Author "Schaefer, Martin H."

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  • Crépieux, Pascale; Poupon, Anne; Langonné Gallay, Nathalie; Reiter, Éric R.; Delgado Blanco, Javier; Schaefer, Martin H.; Bourquard, Thomas; Serrano Pubull, Luis, 1982-; Kiel, Christina (Frontiers, 2017)
    G protein-coupled receptors (GPCRs) are membrane receptors critically involved in sensing the environment and orchestrating physiological processes. As such, they transduce extracellular signals such as hormone, ...
  • Cramer, Dina; Serrano Pubull, Luis, 1982-; Schaefer, Martin H. (eLife, 2016)
    Copy number alterations (CNAs) in cancer patients show a large variability in their number, length and position, but the sources of this variability are not known. CNA number and length are linked to patient survival, ...
  • Schaefer, Martin H.; Serrano Pubull, Luis, 1982- (Nature Publishing Group, 2016)
    One of the biggest mysteries in cancer research remains why mutations in certain genes cause cancer only at specific sites in the human body. The poor correlation between the expression level of a cancer gene and the tissues ...
  • Alanis-Lobato, Gregorio; Andrade-Navarro, Miguel A.; Schaefer, Martin H. (Oxford University Press, 2017)
    The increasing number of experimentally detected interactions between proteins makes it difficult for researchers to extract the interactions relevant for specific biological processes or diseases. This makes it necessary ...
  • Benisty, Hannah, 1986-; Weber, Marc; Hernandez-Alias, Xavier; Schaefer, Martin H.; Serrano Pubull, Luis, 1982- (National Academy of Sciences, 2020)
    It is well known that in cancer gene families some members are more frequently mutated in tumor samples than their family counterparts. A paradigmatic case of this phenomenon is KRAS from the RAS family. Different explanations ...
  • Zapata Ortiz, Luis, 1985-; Pich, Oriol; Serrano Pubull, Luis, 1982-; Kondrashov, Fyodor A., 1979-; Ossowski, Stephan; Schaefer, Martin H. (BioMed Central, 2018)
    Background: Natural selection shapes cancer genomes. Previous studies used signatures of positive selection to identify genes driving malignant transformation. However, the contribution of negative selection against somatic ...
  • Head, Sarah A.; Hernandez-Alias, Xavier; Yang, Jae-Seong; Ciampi, Ludovica; Beltran-Sastre, Violeta; Torres Méndez, Antonio, 1992-; Irimia Martínez, Manuel; Schaefer, Martin H.; Serrano Pubull, Luis, 1982- (Public Library of Science (PLoS), 2021)
    RNA splicing is widely dysregulated in cancer, frequently due to altered expression or activity of splicing factors (SFs). Microexons are extremely small exons (3-27 nucleotides long) that are highly evolutionarily conserved ...
  • Hernandez-Alias, Xavier; Katanski, Christopher D.; Zhang, Wen; Assari, Mahdi; Watkins, Christopher P.; Schaefer, Martin H.; Serrano Pubull, Luis, 1982-; Pan, Tao (Oxford University Press, 2023)
    Transfer RNA (tRNA) utilizes multiple properties of abundance, modification, and aminoacylation in translational regulation. These properties were typically studied one-by-one; however, recent advance in high throughput ...
  • Hosp, Fabian; Gutiérrez Ángel, Sara; Schaefer, Martin H.; Cox, Jürgen; Meissner, Felix; Hipp, Mark Steffen; Hartl, F. Ulrich; Klein, Rüdiger; Dudanova, Irina; Mann, Matthias (Elsevier, 2017)
    Aggregation of polyglutamine-expanded huntingtin exon 1 (HttEx1) in Huntington's disease (HD) proceeds from soluble oligomers to late-stage inclusions. The nature of the aggregates and how they lead to neuronal dysfunction ...
  • Dmitrijeva, Marija; Ossowski, Stephan; Serrano Pubull, Luis, 1982-; Schaefer, Martin H. (Oxford University Press, 2018)
    DNA methylation is an epigenetic mechanism known to affect gene expression and aberrant DNA methylation patterns have been described in cancer. However, only a small fraction of differential methylation events target genes ...
  • Hernandez-Alias, Xavier; Benisty, Hannah, 1986-; Schaefer, Martin H.; Serrano Pubull, Luis, 1982- (Cell Press, 2021)
    Viruses need to hijack the translational machinery of the host cell for a productive infection to happen. However, given the dynamic landscape of tRNA pools among tissues, it is unclear whether different viruses infecting ...
  • Hernandez Alias, Xavier (Universitat Pompeu Fabra, 2023-02-28)
    Malgrat teixits diferents presenten diferències en l'ús de codons i en els repertoris d'anticodons dels ARNt, el coneixement sobre la co-adaptació entre codó-anticodó en eucariotes multicel·lulars és incomplet. D'una banda, ...
  • Hernandez-Alias, Xavier; Benisty, Hannah, 1986-; Schaefer, Martin H.; Serrano Pubull, Luis, 1982- (Wiley-VCH Verlag, 2020)
    Different tissues express genes with particular codon usage and anticodon tRNA repertoires. However, the codon-anticodon co-adaptation in humans is not completely understood, nor is its effect on tissue-specific protein ...
  • Hernandez-Alias, Xavier; Benisty, Hannah, 1986-; Radusky, Leandro; Serrano Pubull, Luis, 1982-; Schaefer, Martin H. (BioMed Central, 2023)
    Background: Codon usage and nucleotide composition of coding sequences have profound effects on protein expression. However, while it is recognized that different tissues have distinct tRNA profiles and codon usages in ...

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