Browsing by Author "Sanchez de Groot, Natalia"

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  • A coordinated response at the transcriptome and interactome level is required to ensure uropathogenic Escherichia coli survival during bacteremia
    Sanchez de Groot, Natalia; Torrent Burgas, Marc (MDPI, 2019)
    Localized infections or disruption of the skin barrier can enable the entry of bacteria into the bloodstream, possibly leading to acute inflammation and sepsis. There is currently no holistic view on how bacteria can survive ...
  • Advances in the characterization of RNA-binding proteins
    Marchese, Domenica, 1986-; Sanchez de Groot, Natalia; Lorenzo Gotor, Maria de las Nieves; Livi, Carmen Maria; Tartaglia, Gian Gaetano (Wiley, 2016)
    From transcription, to transport, storage, and translation, RNA depends on association with different RNA-binding proteins (RBPs). Methods based on next-generation sequencing and protein mass-spectrometry have started to ...
  • Affinity and competition for TBP are molecular determinants of gene expression noise
    Ravarani, Charles N.J.; Chalancon, Guilhem; Breker, Michal; Sanchez de Groot, Natalia; Madan Babu, M. (Nature Publishing Group, 2016)
    Cell-to-cell variation in gene expression levels (noise) generates phenotypic diversity and is an important phenomenon in evolution, development and disease. TATA-box binding protein (TBP) is an essential factor that is ...
  • Bacteria use structural imperfect mimicry to hijack the host interactome
    Sanchez de Groot, Natalia; Torrent Burgas, Marc (Public Library of Science (PLoS), 2020)
    Bacteria use protein-protein interactions to infect their hosts and hijack fundamental pathways, which ensures their survival and proliferation. Hence, the infectious capacity of the pathogen is closely related to its ...
  • Centrality in the host-pathogen interactome is associated with pathogen fitness during infection
    Crua Asensio, Núria; Muñoz Giner, Elisabet; Sanchez de Groot, Natalia; Torrent, Marc (Nature Publishing Group, 2017)
    To perform their functions proteins must interact with each other, but how these interactions influence bacterial infection remains elusive. Here we demonstrate that connectivity in the host-pathogen interactome is directly ...
  • Characterization of soft amyloid cores in human prion-like proteins
    Batlle, Cristina; Sanchez de Groot, Natalia; Iglesias, Valentin; Navarro, Susanna; Ventura, Salvador (Nature Publishing Group, 2017)
    Prion-like behaviour is attracting much attention due to the growing evidences that amyloid-like self-assembly may reach beyond neurodegeneration and be a conserved functional mechanism. The best characterized functional ...
  • Protein aggregation into insoluble deposits protects from oxidative stress
    Carija, Anita; Navarro, Susanna; Sanchez de Groot, Natalia; Ventura, Salvador (Elsevier, 2017)
    Protein misfolding and aggregation have been associated with the onset of neurodegenerative disorders. Recent studies demonstrate that the aggregation process can result in a high diversity of protein conformational states, ...
  • RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43
    Zacco, Elsa; Graña-Montes, Ricardo; Martin, Stephen R.; Sanchez de Groot, Natalia; Alfano, Caterina; Tartaglia, Gian Gaetano; Pastore, Annalisa (Elsevier, 2019)
    Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are incurable motor neuron diseases associated with muscle weakness, paralysis and respiratory failure. Accumulation of TAR DNA-binding protein 43 (TDP-43) ...
  • RNA structure drives interaction with proteins
    Sanchez de Groot, Natalia; Armaos, Alexandros, 1989-; Graña-Montes, Ricardo; Alriquet, Marion; Calloni, Giulia; Vabulas, R. Martin; Tartaglia, Gian Gaetano (Nature Research, 2019)
    The combination of high-throughput sequencing and in vivo crosslinking approaches leads to the progressive uncovering of the complex interdependence between cellular transcriptome and proteome. Yet, the molecular determinants ...
  • RNA-protein interactions: central players in coordination of regulatory networks
    Armaos, Alexandros, 1989-; Zacco, Elsa; Sanchez de Groot, Natalia; Tartaglia, Gian Gaetano (Wiley-VCH Verlag, 2021)
    Changes in the abundance of protein and RNA molecules can impair the formation of complexes in the cell leading to toxicity and death. Here we exploit the information contained in protein, RNA and DNA interaction networks ...
  • The fitness cost and benefit of phase-separated protein deposits
    Sanchez de Groot, Natalia; Torrent, Marc; Ravarani, Charles N.J.; Trusina, Ala; Ventura, Salvador; Babu, M. Madan (Wiley-VCH Verlag, 2019)
    Phase separation of soluble proteins into insoluble deposits is associated with numerous diseases. However, protein deposits can also function as membrane-less compartments for many cellular processes. What are the fitness ...