Browsing by Author "Salvatella, Xavier"

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  • A glutamine-based single α-helix scaffold to target globular proteins
    Escobedo, Albert; Piccirillo, Jonathan; Aranda, Juan; Diercks, Tammo; Mateos, Borja; Garcia-Cabau, Carla; Sánchez-Navarro, Macarena; Topal, Busra; Biesaga, Mateusz; Staby, Lasse; Kragelund, Birthe B.; García, Jesús; Millet, Oscar; Orozco, Modesto; Coles, Murray; Crehuet, Ramon; Salvatella, Xavier (Nature Research, 2022)
    The binding of intrinsically disordered proteins to globular ones can require the folding of motifs into α-helices. These interactions offer opportunities for therapeutic intervention but their modulation with small molecules ...
  • FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth.
    Slebe Concha, Juan Felipe, 1981-; Rojo, Federico; Vinaixa, Maria; García-Rocha, Mar; Testoni, Giorgia; Guiu, Marc; Planet, Evarist; Samino, Sara; Arenas, Enrique J.; Beltran Marqués, Antoni; Rovira Guerín, Ana; Lluch, Ana; Salvatella, Xavier; Yanes, Oscar; Albanell Mestres, Joan; Guinovart, Joan J. (Joan Josep), 1947-; Gomis, Roger R. (Nature Publishing Group, 2016)
    The mechanisms that allow breast cancer (BCa) cells to metabolically sustain rapid growth are poorly understood. Here we report that BCa cells are dependent on a mechanism to supply precursors for intracellular lipid ...
  • Homage to Chris Dobson
    Baum, Jean; Chiti, Fabrizio; de Simone, Alfonso; Knowles, Tuomas P.J.; Kumita, Janet R.; Radford, Sheena E.; Robinson, Carol V.; Salvatella, Xavier; Valelli, Karen; Vendruscolo, Michele; Pastore, Annalisa; Tartaglia, Gian Gaetano (Frontiers, 2019)
  • Regulation of androgen receptor activity by transient interactions of its transactivation domain with general transcription regulators
    De Mol, Eva; Szulc, Elzbieta; Di Sanza, Claudio; Martínez-Cristóbal, Paula; Bertoncini, Carlos W.; Fenwick, R. Bryn; Frigolé-Vivas, Marta; Masín, Marianela; Hunter, Irene; Buzón, Víctor; Brun-Heath, Isabelle; García, Jesús; De Fabritiis, Gianni; Estébanez-Perpiñá, Eva; McEwan, Iain J.; Nebreda, Ángel R.; Salvatella, Xavier (Elsevier, 2018)
    The androgen receptor is a transcription factor that plays a key role in the development of prostate cancer, and its interactions with general transcription regulators are therefore of potential therapeutic interest. The ...