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A Mediterranean diet supplemented with extra virgin olive oil or nuts improves endothelial markers involved in blood pressure control in hypertensive women

Storniolo, Carolina Emilia; Casillas, Rosario; Bulló, Mònica; Castañer, Olga; Ros, Emilio; Sáez, Guillermo; Toledo, Estefania; Estruch, Ramón; Ruiz-Gutiérrez, Valentina; Fitó Colomer, Montserrat; Martínez-González, Miguel A.; Salas-Salvadó, Jordi; Mitjavila, María Teresa; Moreno, Juan José (Springer, 2017)

PURPOSE: Serum nitric oxide (NO) reduction and increased endothelin-1 (ET-1) play a pivotal role in endothelial dysfunction and hypertension. Considering that traditional Mediterranean diet (TMD) reduces blood pressure ...
Adopting a high-polyphenolic diet is associated with an improved glucose profile: Prospective analysis within the PREDIMED-Plus trial

Tresserra-Rimbau, Anna; Fitó Colomer, Montserrat; Castañer, Olga; López Grau, Mercè; Vila Vergaz, Manel; Salas-Salvadó, Jordi (MDPI, 2022)

Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a ...
American Heart Association's life simple 7 and the risk of atrial fibrillation in the PREDIMED study cohort

Díaz-Gutiérrez, Jesús; Martínez-González, Miguel A.; Alonso, Alvaro; Toledo, Estefania; Salas-Salvadó, Jordi; Sorlí, José Vicente; Ros, Emilio; Fitó Colomer, Montserrat; Estruch, Ramón; Arós, Fernando; Fiol, Miquel; Lapetra, José; Gómez-Gracia, Enrique; Serra-Majem, Luis; Pintó Sala, Xavier; Portolés, Olga; Babio, Nancy; Castañer, Olga; Ruiz-Canela, Miguel (Elsevier, 2023)

Background and aims: The American Heart Association proposed 7 ideal cardiovascular health metrics (Life's Simple 7 [LS7]) namely, not smoking, body mass index <25 kg/m2, healthy diet, moderate physical activity ≥150 ...
Association between the 2018 WCRF/AICR and the low-risk lifestyle scores with colorectal cancer risk in the Predimed Study

Barrubés, Laura; Babio, Nancy; Hernández-Alonso, Pablo; Toledo, Estefania; Estruch, Ramón; Ros, Emilio; Fitó Colomer, Montserrat; Alonso-Gómez, Ángel; Fiol, Miquel; Lapetra, José; Serra-Majem, Luis; Pintó Sala, Xavier; Ruiz-Canela, Miguel; Corella, Dolores; Castañer, Olga; Macías-González, Manuel; Salas-Salvadó, Jordi (MDPI, 2020)

Limited longitudinal studies have been conducted to evaluate colorectal cancer (CRC) incidence based on the updated 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations or other ...
Association of adherence to the mediterranean diet with urinary factors favoring renal lithiasis: cross-sectional study of overweight individuals with metabolic síndrome

Prieto, Rafael M.; Rodríguez, Adrian; Sanchís, Pilar; Morey, Marga; Fiol, Miquel; Grases, Félix; Castañer, Olga; Martínez-González, Miguel A.; Salas-Salvadó, Jordi; Romaguera, Dora (MDPI, 2019)

Our purpose was to study the relationship of adherence to the Mediterranean diet (MedDiet) with urinary factors that favor the formation of renal calcium and uric acid stones in overweight and obese participants who had ...
Baseline drinking water consumption and changes in body weight and waist circumference at 2-years of follow-up in a senior Mediterranean population

Paz-Graniel, Indira; Schröder, Helmut, 1958-; Castañer, Olga; Salas-Salvadó, Jordi (Elsevier, 2021)

Background & aims: The association between drinking water consumption and adiposity has been poorly explored. Therefore, we aimed to analyse the associations between the frequency of drinking water consumption and body ...
Benefits of the Mediterranean Diet: Insights From the PREDIMED Study.

Martínez-González, Miguel A.; Salas-Salvadó, Jordi; Estruch, Ramón; Corella, Dolores; Fitó Colomer, Montserrat; Ros, Emilio; PREDIMED investigators (Elsevier, 2015)

The PREDIMED (PREvención con DIeta MEDiterránea) multicenter, randomized, primary prevention trial assessed the long-term effects of the Mediterranean diet (MeDiet) on clinical events of cardiovascular disease (CVD). We ...
CD142+/CD61+, CD146+ and CD45+ microparticles predict cardiovascular events in high risk patients following a Mediterranean diet supplemented with nuts.

Chiva-Blanch, Gemma; Crespo, Javier; Suades Soler, Rosa, 1984-; Arderiu, Gemma; Padró, Teresa; Vilahur, Gemma; Cubedo, Judith; Corella, Dolores; Salas-Salvadó, Jordi; Arós, Fernando; Martínez-González, Miguel A.; Ros, Emilio; Fitó Colomer, Montserrat; Estruch, Ramón; Badimón, Lina, 1953- (Schattauer, 2016)

Circulating microparticles (cMPs) are small phospholipid-rich microvesicles shed by activated cells that play a pivotal role in cell signalling related to the pathogenesis of atherothrombosis. We aimed to investigate the ...
CD3(+)/CD45(+) and SMA-α(+) circulating microparticles are increased in individuals at high cardiovascular risk who will develop a major cardiovascular event.

Chiva-Blanch, Gemma; Suades Soler, Rosa, 1984-; Crespo, Javier; Vilahur, Gemma; Arderiu, Gemma; Padró, Teresa; Corella, Dolores; Salas-Salvadó, Jordi; Arós, Fernando; Martínez-González, Miguel A.; Ros, Emilio; Fitó Colomer, Montserrat; Estruch, Ramón; Badimón, Lina, 1953- (Elsevier, 2016)

Circulating microparticles (cMPs) are phospholipid-rich blebs of 0.1–1.0 μm in size shed from the plasma membrane of eukaryotic cells when injured, activated, or undergoing apoptosis. MPs have been shown to reflect cellular ...
CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial.

Corella, Dolores; Asensio, Eva María; Coltell, Oscar; Sorlí, José Vicente; Ramón, Estruch; Martínez-González, Miguel A.; Salas-Salvadó, Jordi; Castañer, Olga; Arós, Fernando; Lapetra, José; Serra-Majem, Luis; Gómez-Gracia, Enrique; Ortega‑Azorín, Carolina; Fiol, Miquel; Díez Espino, Javier; Díaz‑López, Andrés; Fitó Colomer, Montserrat; Ros, Emilio; Ordovás, José M. (Springer Verlag, 2016)

BACKGROUND: Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). Circadian rhythms are generated by ...
Consumption of iogurt, low-fat milk, and other low-fat dairy products is associated with lower risk of metabolic syndrome incidence in an elderly mediterranean population.

Babio, Nancy; Becerra-Tomás, Nerea; Martínez-González, Miguel A.; Corella, Dolores; Estruch, Ramón; Ros, Emilio; Sayón-Orea, Carmen; Fitó Colomer, Montserrat; Serra-Majem, Luis; Arós, Fernando; Lamuela-Raventós, Rosa M.; Lapetra, José; Gómez-Gracia, Enrique; Fiol, Miquel; Díaz‑López, Andrés; Sorlí, José Vicente; Martínez, José Alfredo; Salas-Salvadó, Jordi; PREDIMED investigators (American Society for Nutrition, 2015)

BACKGROUND: The association between consumption of dairy products and the risk of developing metabolic syndrome (MetS) is unclear./nOBJECTIVE: The purpose of this study was to evaluate the associations between consumption ...
COSMIC project: consensus on the objectives of the metabolic syndrome in clinic

Pedro-Botet, Juan Carlos; Ascaso Gimilio, Juan Francisco; Barrios Alonso, Vivencio; Sierra, Alejandro de la; Escalada, Francisco Javier; Millán Núñez-Cortés, Jesús; Mostaza, José María; Pérez-Martínez, Pablo; Pintó Sala, Xavier; Salas-Salvadó, Jordi; Valdivielso, Pedro (Dove Medical Pres, 2018)

Metabolic syndrome (MetS), a disorder with a high and growing prevalence, is a recognized risk factor for cardiovascular disease (CVD) and type 2 diabetes. It is a constellation of clinical and metabolic risk factors that ...
Dairy product consumption and risk of type 2 diabetes in an elderly Spanish Mediterranean population at high cardiovascular risk.

Díaz‑López, Andrés; Bulló, Mònica; Martínez-González, Miguel A.; Corella, Dolores; Estruch, Ramón; Fitó Colomer, Montserrat; Gómez-Gracia, Enrique; Fiol, Miquel; García de la Corte, Francisco Javier; Ros, Emilio; Babio, Nancy; Serra-Majem, Luis; Pinto, Xavier; Muñoz, Miguel Ángel; Francés, Francisco; Buil-Cosiales, Pilar; Salas-Salvadó, Jordi (Springer Verlag , 2016)

PURPOSE The possible effects of dairy consumption on diabetes prevention remain controversial. The aim of this study was to investigate the association between the dairy consumption and type 2 diabetes (T2D) risk in an ...
Dietary inflammatory index and anthropometric measures of obesity in a population sample at high cardiovascular risk from the PREDIMED (PREvención con DIeta MEDiterránea) trial.

Ruiz-Canela, Miguel; Zazpe, Itziar; Shivappa, Nitin; Hébert, JR.; Sánchez-Tainta, Ana; Corella, Dolores; Salas-Salvadó, Jordi; Fitó Colomer, Montserrat; Lamuela-Raventós, Rosa M.; Rekondo, J.; Fernández-Crehuet, J.; Fiol, Miquel; Santos-Lozano, José; Serra-Majem, Luis; Pinto, Xavier; Martínez, José Alfredo; Ros, Emilio; Estruch, Ramón; Martínez-González, Miguel A. (Cambridge University Press, 2015)

The dietary inflammatory index (DII) is a new tool to assess the inflammatory potential of the diet. In the present study, we aimed to determine the association between the DII and BMI, waist circumference and waist:height ...
Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status

Khoury, Nadine; Castañer, Olga; Salas-Salvadó, Jordi (Elsevier, 2023)

Introduction The principal source of exposure to Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors ...
Dietary Polyphenols, Mediterranean Diet, Prediabetes, and Type 2 Diabetes: A Narrative Review of the Evidence

Guasch Ferré, Marta; Merino, Jorsi; Sun, Qi; Fitó Colomer, Montserrat; Salas-Salvadó, Jordi (Hindawi, 2017)

Dietary polyphenols come mainly from plant-based foods including fruits, vegetables, whole grains, coffee, tea, and nuts. Polyphenols may influence glycemia and type 2 diabetes (T2D) through different mechanisms, such as ...
Dietary total antioxidant capacity and mortality in the PREDIMED study.

Henríquez-Sánchez, P.; Sánchez-Villegas, A.; Ruano-Rodríguez, C.; Gea, Alfredo; Lamuela-Raventós, Rosa M.; Estruch, Ramón; Salas-Salvadó, Jordi; Covas Planells, Maria Isabel; Corella, Dolores; Schröder, Helmut, 1958-; Gutierrez-Bedmar, Mario; Santos-Lozano, José; Pinto, Xavier; Arós, Fernando; Fiol, Miquel; Tresserra-Rimbau, Anna; Ros, Emilio; Martínez-González, Miguel A.; Serra-Majem, Luis; PREDIMED investigators (Springer, 2016)

PURPOSE: The aim of the present study was to assess the association between the dietary total antioxidant capacity, the dietary intake of different antioxidants and mortality in a Mediterranean population at high cardiovascular ...
Does the Mediterranean diet counteract the adverse effects of abdominal adiposity?

Eguaras, Sonia; Toledo, Estefania; Buil-Cosiales, Pilar; Salas-Salvadó, Jordi; Corella, Dolores; Gutierrez-Bedmar, Mario; Santos-Lozano, José; Arós, Fernando; Fiol, Miquel; Fitó Colomer, Montserrat; Ros, Emilio; Serra-Majem, Luis; Pinto, Xavier; Martínez, José Alfredo; Sorlí, José Vicente; Muñoz, Miguel Ángel; Basora, Josep; Estruch, Ramón; Martínez-González, Miguel A.; PREDIMED investigators (Elsevier, 2015)

BACKGROUND AND AIM: We tested the hypothesis that an intervention with a Mediterranean diet (MeDiet) could mitigate the well-known harmful effects of abdominal obesity on cardiovascular health. METHODS AND RESULTS: We ...
Effectiveness of the physical activity intervention program in the PREDIMED-Plus study: a randomized controlled trial

Schröder, Helmut, 1958-; Cárdenas Fuentes, Gabriela, 1985-; Goday Arno, Alberto; Salas-Salvadó, Jordi; REDIMED-Plus investigators (BioMed Central, 2018)

BACKGROUND: The development and implementation of effective physical activity (PA) intervention programs is challenging, particularly in older adults. After the first year of the intervention program used in the ongoing ...
Effects of polyphenol, measured by a biomarker of total polyphenols in urine, on cardiovascular risk factors after a long-term follow-up in the PREDIMED Study.

Guo, Xiaohui; Tresserra-Rimbau, Anna; Estruch, Ramón; Martínez-González, Miguel A.; Medina-Remón, Alexander; Castañer, Olga; Corella, Dolores; Salas-Salvadó, Jordi; Lamuela-Raventós, Rosa M. (Hindawi Publishing Corporation, 2016)

Several epidemiological studies have shown an inverse association between the consumption of polyphenol-rich foods and risk of cardiovascular diseases. However, accuracy and reliability of these studies may be increased ...