Visualitza per autoria "Sala Vila, Aleix"

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  • Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum
    Milà Alomà, Marta; Salvadó, Gemma; Gispert López, Juan Domingo; Vilor Tejedor, Natàlia, 1988-; Grau-Rivera, Oriol; Sala Vila, Aleix; Sánchez Benavides, Gonzalo; Arenaza Urquijo, Eider M.; Crous-Bou, Marta; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Molinuevo, José Luis; ALFA Study (Wiley, 2020)
    Introduction: The biological pathways involved in the preclinical stage of the Alzheimer's continuum are not well understood. Methods: We used NeuroToolKit and Elecsys® immunoassays to measure cerebrospinal fluid (CSF) ...
  • Amyloid-β positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to lower hippocampal volume
    Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Milà Alomà, Marta; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Operto, Grégory; Domingo Gispert, Juan; Vilor Tejedor, Natàlia, 1988-; Sala Vila, Aleix; Crous-Bou, Marta; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Molinuevo, José Luis; ALFA Study (Elsevier, 2021)
    Neurofilament light chain (NfL) is an axonal protein that when measured in cerebrospinal fluid (CSF) serves as a biomarker of neurodegeneration. We aimed at investigating the association among CSF NfL, presence of Subjective ...
  • Arsenic levels in immigrant children from countries at risk of consuming arsenic polluted water compared to children from Barcelona.
    Piñol, S.; Sala Vila, Aleix; Guzman, C.; Marcos, S.; Joya, Xavier; Puig, Carme; Velasco, Manel; Velez, D.; Vall Combelles, Oriol; García Algar, Oscar (Springer Verlag, 2015)
    Arsenic is a highly toxic element that pollutes groundwater, being a major environmental problem worldwide, especially in the Bengal Basin. About 40% of patients in our outpatient clinics come from those countries, and ...
  • Association of weight change with cerebrospinal fluid biomarkers and amyloid positron emission tomography in preclinical Alzheimer's disease
    Grau-Rivera, Oriol; Navalpotro Gómez, Irene; Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Milà Alomà, Marta; Arenaza Urquijo, Eider M.; Salvadó, Gemma; Sala Vila, Aleix; Shekari, Mahnaz; González de Echávarri, José Maria; Minguillón, Carolina; Niñerola-Baizán, Aida; Perissinotti, Andrés; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (BioMed Central, 2021)
    Background: Recognizing clinical manifestations heralding the development of Alzheimer's disease (AD)-related cognitive impairment could improve the identification of individuals at higher risk of AD who may benefit from ...
  • Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies
    Harris, William S.; Sala Vila, Aleix; The Fatty Acids and Outcomes Research Consortium (FORCE) (Nature Research, 2021)
    The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood ...
  • ChREBP-driven DNL and PNPLA3 expression induced by liquid fructose are essential in the production of fatty liver and hypertriglyceridemia in a high-fat diet-fed rat model
    Velázquez, Ana Magdalena; Bentanachs, Roger; Sala Vila, Aleix; Lázaro, Iolanda; Rodríguez-Morató, Jose, 1987-; Sánchez, Rosa María; Alegret, Marta; Roglans, Núria; Laguna, Juan Carlos (Wiley, 2022)
    Scope: The aim of this study is to delineate the contribution of dietary saturated fatty acids (FA) versus liquid fructose to fatty liver and hypertriglyceridemia. Methods and results: Three groups of female rats are ...
  • Circulating linoleic acid at the time of myocardial infarction and risk of primary ventricular fibrillation
    Oliveras, Teresa; Lázaro, Iolanda; Rueda, Ferran; Cediel, German; Bhatt, Deepak L.; Fitó Colomer, Montserrat; Madrid-Gambin, Francisco; Pozo Mendoza, Óscar J., 1975-; Harris, William S.; García-García, Cosme; Sala Vila, Aleix; Bayés-Genís, Antoni (Nature Research, 2022)
    Primary ventricular fibrillation (PVF) is a major driver of cardiac arrest in the acute phase of ST-segment elevation myocardial infarction (STEMI). Enrichment of cardiomyocyte plasma membranes with dietary polyunsaturated ...
  • Circulating Omega-3 fatty acids and incident adverse events in patients with acute myocardial infarction
    Lázaro, Iolanda; Rueda, Ferran; Cediel, German; Ortega, Emilio; García-García, Cosme; Sala Vila, Aleix; Bayés-Genís, Antoni (Elsevier, 2020)
    Background: Dietary omega-3 eicosapentaenoic acid (EPA) has multiple cardioprotective properties. The proportion of EPA in serum phosphatidylcholine (PC) mirrors dietary EPA intake during previous weeks. Circulating EPA ...
  • Cognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF biomarker profile
    Milà Alomà, Marta; Shekari, Mahnaz; Salvadó, Gemma; Gispert López, Juan Domingo; Arenaza Urquijo, Eider M.; Operto, Grégory; Falcón, Carles; Vilor Tejedor, Natàlia, 1988-; Grau-Rivera, Oriol; Sala Vila, Aleix; Sánchez Benavides, Gonzalo; González de Echávarri, José Maria; Minguillón, Carolina; Suárez-Calvet, Marc; Molinuevo, José Luis; ALFA Study (BioMed Central, 2021)
    Background: Understanding the changes that occur in the transitional stage between absent and overt amyloid-β (Aβ) pathology within the Alzheimer's continuum is crucial to develop therapeutic and preventive strategies. The ...
  • CSF synaptic biomarkers in the preclinical stage of Alzheimer disease and their association with MRI and PET: a cross-sectional study
    Milà Alomà, Marta; Brinkmalm, Ann; Ashton, Nicholas J.; Kvartsberg, Hlin; Shekari, Mahnaz; Operto, Grégory; Salvadó, Gemma; Falcon, Carles; Domingo Gispert, Juan; Vilor Tejedor, Natàlia, 1988-; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Sala Vila, Aleix; Sanchez-Benavides, Gonzalo; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Niñerola-Baizán, Aida; Perissinotti, Andrés; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Zetterberg, Henrik; Molinuevo, José Luis; Blennow, Kaj; Suárez-Calvet, Marc; ALFA Study (Lippincott Williams & Wilkins, 2021)
    Background and objectives: To determine whether CSF synaptic biomarkers are altered in the early preclinical stage of the Alzheimer continuum and associated with Alzheimer disease (AD) risk factors, primary pathology, and ...
  • DHA intake relates to better cerebrovascular and neurodegeneration neuroimaging phenotypes in middle-aged adults at increased genetic risk of Alzheimer disease
    Sala Vila, Aleix; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Milà Alomà, Marta; Grau-Rivera, Oriol; González de Echávarri, José Maria; Crous-Bou, Marta; Minguillón, Carolina; Fauria, Karine; Operto, Grégory; Falcón, Carles; Salvadó, Gemma; Cacciaglia, Raffaele; Ingala, Silvia; Barkhof, Frederik; Schröder, Helmut, 1958-; Scarmeas, Nikolaos; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (American Society for Nutrition, 2021)
    Background: The number of APOE-ε4 alleles is a major nonmodifiable risk factor for sporadic Alzheimer disease (AD). There is increasing evidence on the benefits of dietary DHA (22:6n-3) before the onset of AD symptoms, ...
  • Dietary α‐Linolenic Acid, Marine ω‐3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study
    Sala Vila, Aleix; Muñoz, Miguel Ángel; Fitó Colomer, Montserrat; Ros, Emilio; PREDIMED investigators (American Heart Association- Wiley, 2016)
    BACKGROUND: Epidemiological evidence suggests a cardioprotective role of α-linolenic acid (ALA), a plant-derived ω-3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω-3 fatty acids ...
  • Effect of nuts on markers of inflammation and oxidative stress: a narrative review
    Rajaram, Sujatha; Teixeira Damasceno, Nágila Raquel; Marques Braga, Ribanna Aparecida; Martinez, Raquel; Kris-Etherton, Penny, M.; Sala Vila, Aleix (MDPI, 2023)
    Oxidative stress and inflammation are mediators in the pathophysiology of several non-communicable diseases (NCDs). Tree nuts and peanuts lower risk factors of cardiometabolic disease, including blood lipids, blood pressure ...
  • Effect of walnut consumption on neuropsychological development in healthy adolescents: a multi-school randomised controlled trial
    Pinar-Martí, Ariadna; Gignac, Florence; Fernández-Barrés, Sílvia; Romaguera Bosch, Dora; Sala Vila, Aleix; Lázaro, Iolanda; Ranzani, Otavio; Persavento, Cecilia; Delgado, Anna; Carol, Albert; Torrent, Jaume; Gonzalez, Judith; Roso, Eduard; Barrera Gómez, Jose; López Vicente, Mònica, 1988-; Nieuwenhuijsen, Mark J.; Turner, Michelle C.; Basagaña Flores, Xavier; Sunyer Deu, Jordi; Julvez, Jordi (Elsevier, 2023)
    Background: Omega-3 fatty acids are critical for neuropsychological functioning. Adolescence is increasingly believed to entail brain vulnerability to dietary intake. The potential benefit on adolescent neurodevelopment ...
  • Effects of a low dose of caffeine alone or as part of a green coffee extract, in a rat dietary model of lean non-alcoholic fatty liver disease without inflammation
    Velázquez, Ana Magdalena; Roglans, Núria; Bentanachs, Roger; Gené, Maria; Sala Vila, Aleix; Lázaro, Iolanda; Rodríguez-Morató, Jose, 1987-; Sánchez, Rosa María; Laguna, Juan Carlos; Alegret, Marta (MDPI, 2020)
    Non-alcoholic fatty liver disease is a highly prevalent condition without specific pharmacological treatment, characterized in the initial stages by hepatic steatosis. It was suggested that lipid infiltration in the liver ...
  • Effects of walnut consumption for 2 Years on lipoprotein subclasses among healthy elders: findings from the WAHA randomized controlled trial
    Rajaram, Sujatha; Cofán, Montserrat; Sala Vila, Aleix; Haddad, Ella; Serra-Mir, Mercè; Bitok, Edward; Roth, Irene; Freitas-Simoes, Tania-Marisa; Kaur, Amandeep; Valls Pedret, Cinta; Domenech, Mónica; Oda, Keiji; Corella, Dolores; Sabaté, Joan; Ros, Emilio (Lippincott Williams & Wilkins, 2021)
  • Ellagic tcid as a Tool to limit the diabetes burden: updated evidence
    Amor, Antonio J.; Gómez-Guerrero, Carmen; Ortega, Emilio; Sala Vila, Aleix; Lázaro, Iolanda (MDPI, 2020)
    Oxidative stress contributes not only to the pathogenesis of type 2 diabetes (T2D) but also to diabetic vascular complications. It follows that antioxidants might contribute to limiting the diabetes burden. In this review ...
  • Fatty acids composition of blood cell membranes and peripheral inflammation in the PREDIMED Study: a cross-sectional analysis
    Muralidharan, Jananee; Papandreou, Christopher; Sala Vila, Aleix; Rosique-Esteban, Nuria; Fitó Colomer, Montserrat; Estruch, Ramón; Martínez-González, Miguel A.; Corella, Dolores; Ros, Emilio; Razquin, Cristina; Castañer, Olga; Salas-Salvadó, Jordi; Bulló, Mònica (MDPI, 2019)
    There is limited evidence from epidemiological studies for the inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. Therefore, this study examined associations between baseline (n = 282) and ...
  • Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity
    Barradas, Marta; Lázaro, Iolanda; Pozo Mendoza, Óscar J., 1975-; Sala Vila, Aleix; Fernandez-Marcos, Pablo J. (Nature Research, 2022)
    Fasting exerts beneficial effects in mice and humans, including protection from chemotherapy toxicity. To explore the involved mechanisms, we collect blood from humans and mice before and after 36 or 24 hours of fasting, ...
  • Genetically predicted telomere length and Alzheimer's disease endophenotypes: a Mendelian randomization study
    Rodríguez-Fernández, Blanca; Vilor Tejedor, Natàlia, 1988-; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Operto, Grégory; Minguillón, Carolina; Navarro i Cuartiellas, Arcadi, 1969-; Gispert López, Juan Domingo; Sala Vila, Aleix; ALFA Study (BioMed Central, 2022)
    Telomere length (TL) is associated with biological aging, consequently influencing the risk of age-related diseases such as Alzheimer's disease (AD). We aimed to evaluate the potential causal role of TL in AD endophenotypes ...

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