Browsing by Author "Sahún, Ignasi"

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  • DREAM controls the on/off switch of specific activity-dependent transcription pathways
    Mellström, Britt; Sahún, Ignasi; Ruiz Nuño, Ana; Murtra, Patricia; Gómez Villafuertes, Rosa; Savignac, Magalí; Oliveros, Juan C.; González, Paz; Kastanauskaite, Asta; Knafo, Shira; Zhuo, Min; Higuera Matas, Alejandro; Errington, Michael L.; Maldonado, Rafael, 1961-; De Felipe, Javier; Jefferys, John G.R.; Bliss, Tim V. P.; Dierssen, Mara; Naranjo, José R. (American Society for Microbiology, 2014)
    Changes in nuclear Ca(2+) homeostasis activate specific gene expression programs and are central to the acquisition and storage of information in the brain. DREAM (downstream regulatory element antagonist modulator), also ...
  • Impaired development of neocortical circuits contributes to the neurological alterations in DYRK1A haploinsufficiency syndrome
    Arranz, Juan; Balducci, Elisa, 1981-; Arató, Krisztina, 1981-; Sánchez-Elexpuru, Gentzane; Najas Sales, Sònia, 1985-; Parras, Alberto; Rebollo, Elena; Pijuan, Isabel; Erb, Ionas; Verde, Gaetano; Sahún, Ignasi; Barallobre, María José; Lucas, José J.; Sánchez, Marina P.; de la Luna, Susana; Arbonés de Rafael, Maria Lourdes, 1959- (Elsevier, 2019)
    Autism spectrum disorders are early onset neurodevelopmental disorders characterized by deficits in social communication and restricted repetitive behaviors, yet they are quite heterogeneous in terms of their genetic basis ...
  • Intracisternal Gtf2igene therapy ameliorates deficits in cognition and synaptic plasticity of a mouse model of Williams-Beuren Syndrome
    Borralleras Fumaña, Cristina, 1988-; Sahún, Ignasi; Pérez Jurado, Luis Alberto; Campuzano Uceda, María Victoria (Nature Publishing Group, 2015)
    Williams-Beuren syndrome (WBS) is a neurodevelopmental disorder caused by a heterozygous deletion of 26-28 genes at chromosome band 7q11.23. Haploinsufficiency at GTF2I has been shown to play a major role in the neurobehavioral ...
  • Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region
    Brault, Véronique; Duchon, Arnaud; Romestaing, Caroline; Sahún, Ignasi; Pothion, Stéphanie; Karout, Mona; Borel, Christelle; Dembele, Doulaye; Bizot, Jean-Charles; Messaddeq, Nadia; Sharp, Andrew J.; Roussel, Damien; Antonarakis, Stylianos E.; Dierssen, Mara; Hérault, Yann (Public Library of Science (PLoS), 2015)
    The trisomy of human chromosome 21 (Hsa21), which causes Down syndrome (DS), is the most common viable human aneuploidy. In contrast to trisomy, the complete monosomy (M21) of Hsa21 is lethal, and only partial monosomy or ...
  • Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder
    Teixeira, Cátia M.; Martín, Eduardo D.; Sahún, Ignasi; Masachs, Nuria; Pujadas, Lluís; Corvelo, André; Bosch, Carles; Rossi, Daniela; Martínez, Albert; Maldonado, Rafael, 1961-; Dierssen, Mara; Soriano, Eduardo (Nature Publishing Group, 2011)
    Despite the impact of schizophrenia and mood disorders, which in extreme cases can lead to death, recent decades have brought little progress in the development of new treatments. Recent studies have shown that Reelin, an ...

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