Browsing by Author "Sabarinathan, Radhakrishnan"

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  • Vento-Tormo, Roser; Company Nevado, Juan; Rodríguez Ubreva, Javier; de la Rica, Lorenzo; Urquiza, José M.; Javierre, Biola M.; Sabarinathan, Radhakrishnan; Luque, Ana; Esteller, Manel; Aran, Josep M.; Álvarez Errico, Damiana; Ballestar, Esteban (BioMed Central, 2016)
    Background: The role of cytokines in establishing specific transcriptional programmes in innate immune cells has long been recognized. However, little is known about how these extracellular factors instruct innate immune ...
  • Sabarinathan, Radhakrishnan; Mularoni, Loris; Deu-Pons, Jordi; Gonzalez-Perez, Abel; López Bigas, Núria (Nature Publishing Group, 2016)
    Somatic mutations are the driving force of cancer genome evolution. The rate of somatic mutations appears to be greatly variable across the genome due to variations in chromatin organization, DNA accessibility and replication ...
  • Mularoni, Loris; Sabarinathan, Radhakrishnan; González-Pérez, Abel; López Bigas, Núria; Déu Pons, Jordi (Universitat Pompeu Fabra, 2016-06-06)
    Method to identify genomic regions, both coding and non-coding, bearing mutations with significant shift towards high functional impact across a cohort of tumos (FMbias), which are candidates to function as cancer drivers, ...
  • Mularoni, Loris; Sabarinathan, Radhakrishnan; Déu Pons, Jordi; González-Pérez, Abel; López Bigas, Núria (BioMed Central, 2016)
    Distinguishing the driver mutations from somatic mutations in a tumor genome is one of the major challenges of cancer research. This challenge is more acute and far from solved for non-coding mutations. Here we present ...
  • Frigola, Joan; Sabarinathan, Radhakrishnan; Mularoni, Loris; Muiños, Ferran; Gonzalez-Perez, Abel; López Bigas, Núria (Nature Publishing Group, 2017)
    While recent studies have identified higher than anticipated heterogeneity of mutation rate across genomic regions, mutations in exons and introns are assumed to be generated at the same rate. Here we find fewer somatic ...