Browsing by Author "Sánchez-Mejías, Avencia"

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  • CRISPR-Analytics (CRISPR-A): A platform for precise analytics and simulations for gene editing
    Sanvicente García, Marta; García Valiente, Albert; Jouide, Socayna; Jaraba-Wallace, Jessica; Bautista, Eric; Escobosa Olmo, Marc; Sánchez-Mejías, Avencia; Güell Cargol, Marc, 1982- (Public Library of Science (PLoS), 2023)
    Gene editing characterization with currently available tools does not always give precise relative proportions among the different types of gene edits present in an edited bulk of cells. We have developed CRISPR-Analytics, ...
  • Find and cut-and-transfer (FiCAT) mammalian genome engineering
    Pallarès-Masmitjà, Maria; Ivančić, Dimitrije; Mir-Pedrol, Júlia; Jaraba-Wallace, Jessica; Tagliani, Tommaso; Oliva Miguel, Baldomero; Rahmeh, Amal; Sánchez-Mejías, Avencia; Güell Cargol, Marc, 1982- (Nature Research, 2021)
    While multiple technologies for small allele genome editing exist, robust technologies for targeted integration of large DNA fragments in mammalian genomes are still missing. Here we develop a gene delivery tool (FiCAT) ...
  • INSERT-seq enables high-resolution mapping of genomically integrated DNA using Nanopore sequencing
    Ivančić, Dimitrije; Mir-Pedrol, Júlia; Jaraba-Wallace, Jessica; Rafel i Fontanals, Núria, 1954-; Sánchez-Mejías, Avencia; Güell Cargol, Marc, 1982- (BioMed Central, 2022)
    Comprehensive characterisation of genome engineering technologies is relevant for their development and safe use in human gene therapy. Short-read based methods can overlook insertion events in repetitive regions. We develop ...

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