Browsing by Author "Sánchez Benavides, Gonzalo"

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  • A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials
    Sola Llopis, Susana de; Torre Fornell, Rafael de la; Sánchez Benavides, Gonzalo; Benejam, Bessy; Cuenca Royo, Aida Ma, 1981-; Del Hoyo Soriano, Laura; Rodríguez, Joan; Catuara Solarz, Silvina, 1986-; Sánchez Gutiérrez, Judit; Dueñas-Espín, Iván, 1979-; Hernández, Gimena; Peña-Casanova, J. (Jordi); Langohr, Klaus; Videla, Sebastià; Blehaut, Henry; Farré Albaladejo, Magí; Dierssen, Mara; TESDAD Study Group (Frontiers, 2015)
    The recent prospect of pharmaceutical interventions for cognitive impairment of Down syndrome (DS) has boosted a number of clinical trials in this population. However, running the trials has raised some methodological ...
  • Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum
    Milà Alomà, Marta; Salvadó, Gemma; Gispert López, Juan Domingo; Vilor Tejedor, Natàlia, 1988-; Grau-Rivera, Oriol; Sala Vila, Aleix; Sánchez Benavides, Gonzalo; Arenaza Urquijo, Eider M.; Crous-Bou, Marta; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Molinuevo, José Luis; ALFA Study (Wiley, 2020)
    Introduction: The biological pathways involved in the preclinical stage of the Alzheimer's continuum are not well understood. Methods: We used NeuroToolKit and Elecsys® immunoassays to measure cerebrospinal fluid (CSF) ...
  • Amyloid-β positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to lower hippocampal volume
    Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Milà Alomà, Marta; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Operto, Grégory; Domingo Gispert, Juan; Vilor Tejedor, Natàlia, 1988-; Sala Vila, Aleix; Crous-Bou, Marta; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Molinuevo, José Luis; ALFA Study (Elsevier, 2021)
    Neurofilament light chain (NfL) is an axonal protein that when measured in cerebrospinal fluid (CSF) serves as a biomarker of neurodegeneration. We aimed at investigating the association among CSF NfL, presence of Subjective ...
  • APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals
    Cacciaglia, Raffaele; Molinuevo, José Luis; Falcón, Carles; Sánchez Benavides, Gonzalo; Gramunt Fombuena, Nina; Brugulat Serrat, Anna, 1986-; Esteller, Manel; Morán, Sebastián; Fauria, Karine; Gispert López, Juan Domingo; ALFA Study (Elsevier, 2019)
    The APOE-ε4 genotype is the highest genetic risk factor for Alzheimer's disease (AD). In cognitively unimpaired individuals, it has been related to altered brain morphology, function and earlier amyloid beta accumulation. ...
  • APOE-ε4 shapes the cerebral organization in cognitively intact individuals as reflected by structural gray matter networks
    Cacciaglia, Raffaele; Molinuevo, José Luis; Falcón, Carles; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Brugulat Serrat, Anna, 1986-; Blennow, Kaj; Zetterberg, Henrik; Gispert López, Juan Domingo; ALFA Study (Oxford University Press, 2020)
    Gray matter networks (GMn) provide essential information on the intrinsic organization of the brain and appear to be disrupted in Alzheimer's disease (AD). Apolipoprotein E (APOE)-ε4 represents the major genetic risk factor ...
  • Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults
    Grau-Rivera, Oriol; Operto, Grégory; Falcón, Carles; Sánchez Benavides, Gonzalo; Cacciaglia, Raffaele; Brugulat Serrat, Anna, 1986-; Gramunt Fombuena, Nina; Salvadó, Gemma; Suárez-Calvet, Marc; Minguillón, Carolina; Iranzo, Alex; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (BioMed Central, 2020)
    Background: Mounting evidence links poor sleep quality with a higher risk of late-life dementia. However, the structural and cognitive correlates of insomnia are still not well understood. The study aims were to characterize ...
  • Association of weight change with cerebrospinal fluid biomarkers and amyloid positron emission tomography in preclinical Alzheimer's disease
    Grau-Rivera, Oriol; Navalpotro Gómez, Irene; Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Milà Alomà, Marta; Arenaza Urquijo, Eider M.; Salvadó, Gemma; Sala Vila, Aleix; Shekari, Mahnaz; González de Echávarri, José Maria; Minguillón, Carolina; Niñerola-Baizán, Aida; Perissinotti, Andrés; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (BioMed Central, 2021)
    Background: Recognizing clinical manifestations heralding the development of Alzheimer's disease (AD)-related cognitive impairment could improve the identification of individuals at higher risk of AD who may benefit from ...
  • Associations between air pollution and biomarkers of Alzheimer's disease in cognitively unimpaired individuals
    Alemany, Silvia; Vilor Tejedor, Natàlia, 1988-; Milà Alomà, Marta; Suárez-Calvet, Marc; Salvadó, Gemma; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Grau-Rivera, Oriol; Minguillón, Carolina; Fauria, Karine; Domingo Gispert, Juan; Gascon Merlos, Mireia, 1984-; Nieuwenhuijsen, Mark J.; Sunyer Deu, Jordi; ALFA Study (Elsevier, 2021)
    Background: Air quality contributes to incidence of Alzheimer's disease (AD) although the underlying neurobiological mechanisms are unclear. This study was aimed to examine the association between air pollution and ...
  • Awareness of cognitive decline in patients with alzheimer's disease: a systematic review and meta-Analysis
    Cacciamani, Federica; Houot, Marion; Gagliardi, Geoffroy; Dubois, Bruno; Sikkes, Sietske; Sánchez Benavides, Gonzalo; Denicolò, Elena; Molinuevo, José Luis; Vannini, Patrizia; Epelbaum, Stéphane (Frontiers, 2021)
    Background: Identifying a poor degree of awareness of cognitive decline (ACD) could represent an early indicator of Alzheimer's disease (AD). Objectives: (1) to understand whether there is evidence of poor ACD in the ...
  • Cognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF biomarker profile
    Milà Alomà, Marta; Shekari, Mahnaz; Salvadó, Gemma; Gispert López, Juan Domingo; Arenaza Urquijo, Eider M.; Operto, Grégory; Falcón, Carles; Vilor Tejedor, Natàlia, 1988-; Grau-Rivera, Oriol; Sala Vila, Aleix; Sánchez Benavides, Gonzalo; González de Echávarri, José Maria; Minguillón, Carolina; Suárez-Calvet, Marc; Molinuevo, José Luis; ALFA Study (BioMed Central, 2021)
    Background: Understanding the changes that occur in the transitional stage between absent and overt amyloid-β (Aβ) pathology within the Alzheimer's continuum is crucial to develop therapeutic and preventive strategies. The ...
  • Cross-sectional and longitudinal association of sleep and Alzheimer biomarkers in cognitively unimpaired adults
    Blackman, Jonathan; Stankeviciute, Laura; Arenaza Urquijo, Eider M.; Suárez-Calvet, Marc; Sánchez Benavides, Gonzalo; Vilor Tejedor, Natàlia, 1988-; Iranzo, Alejandro; Molinuevo, José Luis; Gispert López, Juan Domingo; Coulthard, Elizabeth; Grau-Rivera, Oriol; European Prevention of Alzheimer’s Disease (EPAD) Consortium (Oxford University Press, 2022)
    Sleep abnormalities are prevalent in Alzheimer's disease, with sleep quality already impaired at its preclinical stage. Epidemiological and experimental data point to sleep abnormalities contributing to the risk of Alzheimer's ...
  • Dementia risk communication. A user manual for brain health Services-part 3 of 6
    Visser Leonie N.C.; Minguillón, Carolina; Sánchez Benavides, Gonzalo; Abramowicz, Marc; Altomare, Daniele; Fauria, Karine; Frisoni, Giovanni B.; Georges, Jean; Ribaldi, Federica; Scheltens, Philip; Jetsk van der Schaar, Philip; Zwan, Marissa; van der Flier, Wiesje M.; Molinuevo, José Luis (BioMed Central, 2021)
    Growing evidence suggests dementia incidence can be reduced through prevention programs targeting risk factors. To accelerate the implementation of such prevention programs, a new generation of brain health services (BHS) ...
  • Desarrollo, estudio de equivalencia y datos normativos de la versión española B del Free and Cued Selective Reminding Test
    Grau-Guinea, L.; Pérez Enríquez, Carmen; García Escobar, Greta; Arrondo-Elizarána, C.; Pereira-Cutiño, B.; Florido-Santiago, Mercedes; Piqué-Candini, J.; Planas, Albert; Paez, M.; Peña Casanova, Jordi; Sánchez Benavides, Gonzalo (Elsevier, 2018)
    INTRODUCTION: The Free and Cued Selective Reminding Test (FCSRT) is widely used for the assessment of verbal episodic memory, mainly in patients with Alzheimer disease. A Spanish version of the FCSRT and normative data ...
  • Development, equivalence study, and normative data of version B of the Spanish-language Free and Cued Selective Reminding Test
    Grau-Guinea, L.; Pérez Enríquez, Carmen; García Escobar, Greta; Arrondo-Elizarána, C.; Pereira-Cutiño, B.; Florido-Santiago, Mercedes; Piqué-Candini, J.; Planas, Albert; Paez, M.; Peña Casanova, Jordi; Sánchez Benavides, Gonzalo (Elsevier, 2021)
    Introduction: The Free and Cued Selective Reminding Test (FCSRT) is widely used for the assessment of verbal episodic memory, mainly in patients with Alzheimer disease. A Spanish-language version of the FCSRT and normative ...
  • DHA intake relates to better cerebrovascular and neurodegeneration neuroimaging phenotypes in middle-aged adults at increased genetic risk of Alzheimer disease
    Sala Vila, Aleix; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Milà Alomà, Marta; Grau-Rivera, Oriol; González de Echávarri, José Maria; Crous-Bou, Marta; Minguillón, Carolina; Fauria, Karine; Operto, Grégory; Falcón, Carles; Salvadó, Gemma; Cacciaglia, Raffaele; Ingala, Silvia; Barkhof, Frederik; Schröder, Helmut, 1958-; Scarmeas, Nikolaos; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (American Society for Nutrition, 2021)
    Background: The number of APOE-ε4 alleles is a major nonmodifiable risk factor for sporadic Alzheimer disease (AD). There is increasing evidence on the benefits of dietary DHA (22:6n-3) before the onset of AD symptoms, ...
  • Enhancing the sensitivity of memory tests: reference data for the free and cued selective reminding test and the logical memory task from cognitively healthy subjects with normal alzheimer's disease cerebrospinal fluid biomarker levels
    Brugulat Serrat, Anna, 1986-; Cañas-Martínez, Alba; Canals-Gispert, Lidia; Marne, Paula; Gramunt Fombuena, Nina; Suárez-Calvet, Marc; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Zetterberg, Henrik; Blennow, Kaj; Gispert López, Juan Domingo; Molinuevo, José Luis; Sánchez Benavides, Gonzalo; ALFA Study (IOS Press, 2021)
    Background: Cognitive performance of a given individual should be interpreted in the context of reference standards obtained in cognitively healthy populations. Recent evidence has shown that removing asymptomatic individuals ...
  • Episodic memory and executive functions in cognitively healthy individuals display distinct neuroanatomical correlates which are differentially modulated by aging
    Cacciaglia, Raffaele; Molinuevo, José Luis; Sánchez Benavides, Gonzalo; Falcón, Carles; Gramunt Fombuena, Nina; Brugulat Serrat, Anna, 1986-; Grau-Rivera, Oriol; Gispert López, Juan Domingo; ALFA Study (Wiley, 2018)
    The neuroanatomical bases of episodic memory (EM) and executive functions (EFs) have been widely addressed in patients with brain damage and in individuals with neurologic disorders. These studies reported that larger brain ...
  • Estudios normativos españoles (Proyecto NEURONORMA Plus): normas para las pruebas Delis Kaplan-Design Fluency Test (DK-DFT), Color Trails Tests (CTT) y Dual Task (DT)
    García Escobar, Greta; Pérez Enríquez, Carmen; Arrondo-Elizarána, C.; Pereira-Cutiño, B.; Grau-Guinea, L.; Florido-Santiago, Mercedes; Piqué-Candini, J.; Manero, Rosa María; Puig-Pijoan, Albert; Peña Casanova, Jordi; Sánchez Benavides, Gonzalo (Elsevier, 2021)
    Introducción: las tareas de atención compleja y fluencia no verbal se utilizan en las valoraciones neuropsicológicas con el objetivo de explorar subdominios de las funciones ejecutivas. El objetivo de este estudio es ...
  • Estudios normativos españoles (proyecto NEURONORMA-Plus): normas para el Wisconsin Card Sorting Test (WCST), la Figura Compleja Modificada de Taylor (FCMT) y el Ruff-Light Trail Learning Test (RULIT)
    Pérez Enríquez, Carmen; García Escobar, Greta; Florido-Santiago, Mercedes; Piqué-Candini, J.; Arrondo-Elizarána, C.; Grau-Guinea, L.; Pereira-Cutiño, B.; Manero, Rosa María; Puig-Pijoan, Albert; Peña Casanova, Jordi; Sánchez Benavides, Gonzalo (Elsevier, 2021)
    Objetivo: ell presente estudio tiene como objetivo proporcionar normas y ajustes para edad, educación y género para el Wisconsin Card Sorting Test (WCST), la Figura Compleja Modificada de Taylor (FCMT) y el Ruff-Light Trail ...
  • Exploring cognitive and biological correlates of sleep quality and their potential links with Alzheimer's disease (ALFASleep project). Protocol for an observational study
    Fauria, Karine; Minguillón, Carolina; Sánchez Benavides, Gonzalo; Arenaza Urquijo, Eider M.; Suárez-Calvet, Marc; Domingo Gispert, Juan; Grau-Rivera, Oriol (BMJ Publishing Group, 2022)
    Introduction: the growing worldwide prevalence of Alzheimer's disease (AD) and the lack of effective treatments pose a dire medical challenge. Sleep disruption is also prevalent in the ageing population and is increasingly ...