Browsing by Author "Rubio Moscardó, Fanny"

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  • LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions
    Serra, Selma A.; Stojakovic, Predrag; Amat, Ramon; Rubio Moscardó, Fanny; Latorre Doménech, Pablo, 1993-; Seisenbacher, Gerhard; Canadell, David; Böttcher, René; Aregger, Michael; Moffat, Jason; Nadal Clanchet, Eulàlia de; Valverde, M. A. (Miguel Ángel), 1963-; Posas Garriga, Francesc (National Academy of Sciences, 2021)
    Regulation of cell volume is essential for tissue homeostasis and cell viability. In response to hypertonic stress, cells need rapid electrolyte influx to compensate water loss and to prevent cell death in a process known ...
  • Lymphocyte Activation Dynamics Is Shaped by Hereditary Components at Chromosome Region 17q12-q21
    Carreras Sureda, Amado, 1986-; Rubio Moscardó, Fanny; Olvera, Alex; Argilaguet Marqués, Jordi, 1977-; Kiefer, Kerstin, 1986-; Mothe, Beatriz; Meyerhans, Andreas; Brander, Christian; Vicente García, Rubén, 1978- (Public Library of Science (PLoS), 2016)
    Single nucleotide polymorphisms (SNPs) located in the chromosome region 17q12-q21 are risk factors for asthma. Particularly, there are cis-regulatory haplotypes within this region that regulate differentially the expression ...
  • Methylglyoxal produced by amyloid-β peptide-induced nitrotyrosination of triosephosphate isomerase triggers neuronal death in Alzheimer's disease
    Tajes Orduña, Marta; Eraso Pichot, Abel; Rubio Moscardó, Fanny; Guivernau Almazán, Biuse, 1988-; Ramos Fernández, Eva, 1984-; Bosch Morató, Mònica, 1986-; Guix Ràfols, Francesc Xavier; Clarimón Echevarría, Jordi; Miscione, Gian Pietro; Boada, Mercè; Gil Gómez, Gabriel; Suzuki, Toshiharu; Molina, Henrik; Villà i Freixa, Jordi; Vicente García, Rubén, 1978-; Muñoz López, Francisco José, 1964- (IOS Press, 2014)
    Amyloid-β peptide (Aβ) aggregates induce nitro-oxidative stress, contributing to the characteristic neurodegeneration found in Alzheimer's disease (AD). One of the most strongly nitrotyrosinated proteins in AD is the ...
  • Methylglyoxal reduces mitochondrial potential and activates Bax and caspase-3 in neurons: implications for alzheimer's disease
    Tajes Orduña, Marta; Eraso Pichot, Abel; Rubio Moscardó, Fanny; Guivernau Almazán, Biuse, 1988-; Bosch Morató, Mònica, 1986-; Valls Comamala, Victòria, 1987-; Miscione, Gian Pietro; Villà i Freixa, Jordi; Suzuki, Toshiharu; Muñoz López, Francisco José, 1964- (Elsevier, 2014)
    Alzheimer's disease (AD) is characterized by the oxidative stress generated from amyloid β-peptide (Aβ) aggregates. It produces protein nitrotyrosination, after the reaction with nitric oxide to form peroxynitrite, being ...
  • Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset alzheimer's disease patients alter calcium homeostasis
    Rubio Moscardó, Fanny; Bosch Morató, Mònica, 1986-; Plata, Cristina; Gené, Gemma; Muñoz López, Francisco José, 1964-; Valverde, M. A. (Miguel Ángel), 1963-; Clarimón Echevarría, Jordi (Public Library of Science (PLoS), 2013)
    Calcium signaling in the brain is fundamental to the learning and memory process and there is evidence to suggest that its dysfunction is involved in the pathological pathways underlying Alzheimer’s disease (AD). Recently, ...
  • Structural determinants of 5′,6′-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel
    Berna Erro, Alejandro; Izquierdo Serra, Mercè; Sepúlveda, Romina V.; Rubio Moscardó, Fanny; Doñate-Macián, Pau; Serra Pascual, Selma A., 1981-; Carrillo García, Julia, 1993-; Perálvarez Marín, Alex; González Nilo, Fernando; Fernández-Fernández, José Manuel, 1967-; Valverde, M. A. (Miguel Ángel), 1963- (Nature Publishing Group, 2017)
    TRPV4 cation channel activation by cytochrome P450-mediated derivatives of arachidonic acid (AA), epoxyeicosatrienoic acids (EETs), constitute a major mechanisms of endothelium-derived vasodilatation. Besides, TRPV4 ...
  • The mechanosensitive Piezo1 channel controls endosome trafficking for an efficient cytokinetic abscission
    Carrillo García, Julia, 1993-; Herrera-Fernández, Víctor; Serra, Selma A.; Rubio Moscardó, Fanny; Vogel-González, Marina; Doñate-Macián, Pau; Hevia, Covadonga F.; Pujades Corbi, Cristina; Valverde, M. A. (Miguel Ángel), 1963- (American Association for the Advancement of Science (AAAS), 2021)
    Mechanical forces are exerted throughout cytokinesis, the final step of cell division. Yet, how forces are transduced and affect the signaling dynamics of cytokinetic proteins remains poorly characterized. We now show that ...
  • The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity
    Doñate-Macián, Pau; Jungfleisch, Jennifer, 1986-; Pérez Vilaró, Gemma, 1985-; Rubio Moscardó, Fanny; Perálvarez Marín, Alex; Díez Antón, Juana, 1962-; Valverde, M. A. (Miguel Ángel), 1963- (Nature Publishing Group, 2018)
    Ion channels are well placed to transduce environmental cues into signals used by cells to generate a wide range of responses, but little is known about their role in the regulation of RNA metabolism. Here we show that the ...