Browsing by Author "Rothman, Nathaniel"

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  • A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Rothman, Nathaniel; Real, Francisco X.; Serra, Consol; Lloreta, Josep, 1958-; Chanock, Stephen J. (Nature Research, 2010)
    We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a ...
  • A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background
    García Closas, Montserrat; Hein, David W.; Silverman, Debra T.; Malats i Riera, Núria; Yeager, Meredith; Jacobs, Kevin; Doll, Mark A.; Figueroa, Jonine D.; Baris, Dalsu; Schwenn, Molly; Kogevinas, Manolis; Johnson, Alison; Chatterjee, Nilanjan; Moore, Lee E.; Moeller, Timothy; Real, Francisco X.; Chanock, Stephen J.; Rothman, Nathaniel (Lippincott Williams & Wilkins, 2011)
    The arylamine N-acetyltransferase 2 (NAT2) slow acetylation phenotype is an established risk factor for urinary bladder cancer. We reported earlier on this risk association using NAT2 phenotypic categories inferred from ...
  • Application of multi-SNP approaches Bayesian LASSO and AUC-RF to detect main effects of inflammatory-gene variants associated with bladder cancer risk
    López De Maturana, Evangelina; Ye, Yuanqing; Calle, M. Luz; Rothman, Nathaniel; Urrea, Víctor; Kogevinas, Manolis; Petrus, Sandra; Chanock, Stephen J.; Tardón, Adonina; García Closas, Montserrat; González Neira, Anna; Vellalta, Gemma; Carrato, Alfredo; Navarro i Cuartiellas, Arcadi, 1969-; Lorente-Galdós, Belén, 1981-; Silverman, Debra T.; Real, Francisco X.; Wu, Xifeng; Malats i Riera, Núria (Public Library of Science (PLoS), 2013)
    The relationship between inflammation and cancer is well established in several tumor types, including bladder cancer. We performed an association study between 886 inflammatory-gene variants and bladder cancer risk in ...
  • Bladder cancer and reproductive factors among women in Spain
    Huang, An-Tsun; Kogevinas, Manolis; Silverman, Debra T.; Malats i Riera, Núria; Rothman, Nathaniel; Tardón, Adonina; Serra, Consol; García Closas, Reina; Carrato, Alfredo; Cantor, Kenneth P (Springer, 2009)
    Hormonal factors, possibly related to reproductive characteristics, may play a role in the risk of bladder cancer among women. To study this, we investigated the effects of reproductive factors on female bladder cancer ...
  • Coffee consumption, genetic susceptibility and bladder cancer risk
    Villanueva, Cristina M.; Silverman, Debra T.; Murta-Nascimento, Cristiane; Malats i Riera, Núria; García Closas, Montserrat; Castro Domínguez, Francisco; Tardón, Adonina; García Closas, Reina; Serra, Consol; Carrato, Alfredo; Rothman, Nathaniel; Real, Francisco X.; Dosemeci, Mustafa; Kogevinas, Manolis (Springer, 2009)
    Objective: We evaluated the bladder cancer risk associated with coffee consumption in a case–control study in Spain and examined the gene–environment interactions for genetic variants of caffeine-metabolizing enzymes. ...
  • A fast and accurate method to detect allelic genomic imbalances underlying mosaic rearrangements using SNP array data
    González Ruiz, Juan Ramón; Rodríguez Santiago, Benjamín; Cáceres, Alejandro; Pique Regi, Roger; Rothman, Nathaniel; Chanock, Stephen J.; Armengol i Dulcet, Lluís; Pérez Jurado, Luis Alberto (BioMed Central, 2011)
    Background: Mosaicism for copy number and copy neutral chromosomal rearrangements has been recently identified as a relatively common source of genetic variation in the normal population. However its prevalence is poorly ...
  • Genetic and non-genetic predictors of LINE-1 methylation in leukocyte DNA
    Tajuddin, Salman Muhammad; Amaral, André F.S.; Fernández, Agustín F.; Rodriguez Rodero, Sandra; Rodríguez, Ramón María; Moore, Lee E.; Tardón, Adonina; Carrato, Alfredo; García Closas, Montserrat; Silverman, Debra T.; Jackson, Brian P.; García Closas, Reina; Cook, Ashley L.; Cantor, Kenneth P; Chanock, Stephen J.; Kogevinas, Manolis; Rothman, Nathaniel; Real, Francisco X.; Malats i Riera, Núria (National Institute of Environmental Health Sciences (NIEHS), 2013)
    Background: Altered DNA methylation has been associated with various diseases. Objective: We evaluated the association between levels of methylation in leukocyte DNA at long interspersed nuclear element 1 (LINE-1) and ...
  • Genetic variation in the TP53 pathway and bladder cancer risk: a comprehensive analysis
    Pineda, Silvia; Milne, Roger L.; Calle, M. Luz; Rothman, Nathaniel; López De Maturana, Evangelina; Herranz, Jesús; Kogevinas, Manolis; Chanock, Stephen J.; Tardón, Adonina; Márquez, Mirari; Guey, Lin T.; García Closas, Montserrat; Lloreta, Josep, 1958-; Baum, Erin; González Neira, Anna; Carrato, Alfredo; Navarro i Cuartiellas, Arcadi, 1969-; Silverman, Debra T.; Real, Francisco X.; Malats i Riera, Núria (Public Library of Science (PLoS), 2014)
    Introduction: Germline variants in TP63 have been consistently associated with several tumors, including bladder cancer, indicating the importance of TP53 pathway in cancer genetic susceptibility. However, variants in other ...
  • Genome-wide CNV analysis replicates the association between GSTM1 deletion and bladder cancer: a support for using continuous measurement from SNP-array data
    Marenne, Gaëlle; Real, Francisco X.; Rothman, Nathaniel; Rodríguez Santiago, Benjamín; Pérez Jurado, Luis Alberto; Kogevinas, Manolis; García Closas, Montserrat; Silverman, Debra T.; Chanock, Stephen J.; Génin, Emmanuelle; Malats i Riera, Núria (BioMed Central, 2012)
    BACKGROUND: Structural variations such as copy number variants (CNV) influence the expression of different phenotypic traits. Algorithms to identify CNVs through SNP-array platforms are available. The ability to evaluate ...
  • Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study
    Moore, Lee E.; Pfeiffer, Ruth M.; Poscablo, Cristina; Real, Francisco X.; Kogevinas, Manolis; Silverman, Debra T.; García Closas, Reina; Chanock, Stephen J.; Tardón, Adonina; Serra, Consol; Carrato, Alfredo; Dosemeci, Mustafa; García Closas, Montserrat; Esteller, Manel; Fraga, Mario F.; Rothman, Nathaniel; Malats i Riera, Núria (Elsevier, 2008)
    BACKGROUND: DNA hypomethylation has been suggested to cause genomic instability and increase cancer risk. We aimed to test the hypothesis that DNA hypomethylation is associated with increased risk of bladder cancer. METHODS: ...
  • Large-scale pathway-based analysis of bladder cancer genome-wide association data from five studies of European background
    Menashe, Idan; Real, Francisco X.; Kogevinas, Manolis; Serra, Consol; Lloreta, Josep, 1958-; Rothman, Nathaniel (Public Library of Science (PLoS), 2012)
    Pathway analysis of genome-wide association studies (GWAS) offer a unique opportunity to collectively evaluate genetic variants with effects that are too small to be detected individually. We applied a pathway analysis to ...
  • LINE-1 methylation in granulocyte DNA and trihalomethane exposure is associated with bladder cancer risk
    Salas, Lucas A.; Villanueva Belmonte, Cristina; Tajuddin, Salman Muhammad; Amaral, André F.S.; Fernández, Agustín F.; Moore, Lee E.; Carrato, Alfredo; Tardón, Adonina; Serra, Consol; García Closas, Reina; Basagaña Flores, Xavier; Rothman, Nathaniel; Silverman, Debra T.; Cantor, Kenneth P; Kogevinas, Manolis; Real, Francisco X.; Fraga, Mario F.; Malats i Riera, Núria (Taylor & Francis (Routledge), 2014)
    DNA methylation changes contribute to bladder carcinogenesis. Trihalomethanes (THM), a class of disinfection by-products, are associated with increased urothelial bladder cancer (UBC) risk. THM exposure in animal models ...
  • LINE-1 methylation in leukocyte DNA, interaction with phosphatidylethanolamine N-methyltransferase variants and bladder cancer risk
    Amaral, André F.S.; Tajuddin, Salman Muhammad; Fernández, Agustín F.; Chanock, Stephen J.; Silverman, Debra T.; Tardón, Adonina; Carrato, Alfredo; García Closas, Montserrat; Jackson, Brian P.; Toraño, Estela; Márquez, Miriam; González Urdinguio, Rocío; García Closas, Reina; Rothman, Nathaniel; Kogevinas, Manolis; Real, Francisco X.; Fernández Fraga, Mario; Malats i Riera, Núria (Cancer Research UK, 2014)
    Background: Aberrant global DNA methylation is shown to increase cancer risk. LINE-1 has been proven a measure of global DNA methylation. The objectives of this study were to assess the association between LINE-1 methylation ...
  • Mosaic uniparental disomies and aneuploidies as large structural variants of the human genome
    Rodríguez Santiago, Benjamín; Malats i Riera, Núria; Rothman, Nathaniel; Armengol i Dulcet, Lluís; García Closas, Montserrat; Kogevinas, Manolis; Villa, Olaya; Hutchinson, Amy; Earl, Julie; Marenne, Gaëlle; Jacobs, Kevin; Rico, Daniel; Tardón, Adonina; Carrato, Alfredo; Thomas, Gilles; Valencia, Alfonso; Silverman, Debra T.; Real, Francisco X.; Chanock, Stephen J.; Pérez Jurado, Luis Alberto (Elsevier, 2010)
    Mosaicism is defined as the coexistence of cells with different genetic composition within an individual, caused by postzygotic somatic mutation. Although somatic mosaicism for chromosomal abnormalities is a well-established ...
  • NAT2 slow acetylation and GSTM1 null genotypes increase bladder cancer risk: results from the Spanish Bladder Cancer Study and meta-analyses
    García Closas, Montserrat; Malats i Riera, Núria; Kogevinas, Manolis; Serra, Consol; Lloreta, Josep, 1958-; Castaño Vinyals, Gemma; Torà, Montserrat; Fernández-Avilés, Francisco; Real, Francisco X.; Rothman, Nathaniel (Elsevier, 2005)
    BACKGROUND: Many reported associations between common genetic polymorphisms and complex diseases have not been confirmed in subsequent studies. An exception could be the association between NAT2 slow acetylation, GSTM1 ...
  • NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses
    García Closas, Montserrat; Malats i Riera, Núria; Kogevinas, Manolis; Serra, Consol; Lloreta, Josep, 1958-; Real, Francisco X.; Rothman, Nathaniel (Elsevier, 2005)
    Background: Many reported associations between common genetic polymorphisms and complex diseases have not been confirmed in subsequent studies. An exception could be the association between NAT2 slow acetylation, GSTM1 ...
  • Pancreatic cancer risk and levels of trace elements
    Amaral, André F.S.; Porta Serra, Miquel; Silverman, Debra T.; Milne, Roger L.; Kogevinas, Manolis; Rothman, Nathaniel; Cantor, Kenneth P; Jackson, Brian P.; Pumarega Rodríguez, José Antonio; López, Tomàs; Carrato, Alfredo; Guarner, Luisa; Real, Francisco X.; Malats i Riera, Núria (BMJ Publishing Group, 2012)
    Background and Aims: Knowledge on the aetiology of exocrine pancreatic cancer (EPC) is scant. The best established risk factor for EPC is tobacco smoking. Among other carcinogens, tobacco contains cadmium, a metal previously ...
  • Polymorphisms in GSTT1, GSTZ1, AND CYP2E1, disinfection by-products, and risk of bladder cancer in Spain
    Cantor, Kenneth P; Villanueva Belmonte, Cristina; Silverman, Debra T.; Figueroa, Jonine D.; Real, Francisco X.; García Closas, Montserrat; Malats i Riera, Núria; Chanock, Stephen J.; Yeager, Meredith; Tardón, Adonina; García Closas, Reina; Serra, Consol; Carrato, Alfredo; Castaño Vinyals, Gemma; Samanic, Claudine; Rothman, Nathaniel; Kogevinas, Manolis (National Institute of Environmental Health Sciences (NIEHS), 2010)
    Background: Bladder cancer has been linked with long-term exposure to disinfection by-products (DBPs) in drinking water.Objectives: In this study we investigated the combined influence of DBP exposure and polymorphisms in ...
  • Prediction of non-muscle invasive bladder cancer outcomes assessed by innovative multimarker prognostic models.
    López De Maturana, Evangelina; Picornell, Antoni; Masson-Lecomte, Alexandra; Kogevinas, Manolis; Márquez, Mirari; Carrato, Alfredo; Tardón, Adonina; Lloreta, Josep, 1958-; García Closas, Montserrat; Silverman, Debra T.; Rothman, Nathaniel; Chanock, Stephen J.; Real, Francisco X.; Goddard, M. E.; Malats i Riera, Núria; SBC/EPICURO Study Investigators (BioMed Central, 2016)
    BACKGROUND: We adapted Bayesian statistical learning strategies to the prognosis field to investigate if genome-wide common SNP improve the prediction ability of clinico-pathological prognosticators and applied it to ...
  • Socioeconomic status and exposure to disinfection by-products in drinking water in Spain
    Castaño Vinyals, Gemma; Cantor, Kenneth P; Villanueva Belmonte, Cristina; Tardón, Adonina; García Closas, Reina; Serra, Consol; Carrato, Alfredo; Malats i Riera, Núria; Rothman, Nathaniel; Silverman, Debra T.; Kogevinas, Manolis (BioMed Central, 2011)
    Background: Disinfection by-products in drinking water are chemical contaminants that have been associated with cancer and other adverse effects. Exposure occurs from consumption of tap water, inhalation and dermal absorption. ...

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