Browsing by Author "Rossell, David"

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  • chroGPS, a global chromatin positioning system for the functional analysis and visualization of the epigenome
    Font-Burgada, Joan; Reina García, Óscar, 1976-; Rossell, David; Azorín Marín, Fernando (Oxford University Press, 2014)
    Development of tools to jointly visualize the genome and the epigenome remains a challenge. chroGPS is a computational approach that addresses this question. chroGPS uses multidimensional scaling techniques to represent ...
  • Essays on high-dimensional bayesian inference
    Torrens i Dinarès, Miquel (Universitat Pompeu Fabra, 2022-11-04)
    This thesis studies the capabilities of Bayesian estimators in high-dimen-sional generalised linear models, with a particular focus on treatment effect estimation. The first of four chapters provides the necessary background, ...
  • KairosMS: a new solution for the processing of hyphenated ultrahigh resolution mass spectrometry data
    Gavard, Remy; Jones, Hugh E.; Palacio Lozano, Diana Catalina; Thomas, Mary J.; Rossell, David; Spencer, Simon E.F.; Barrow, Mark P. (American Chemical Society (ACS), 2020)
    The use of hyphenated Fourier transform mass spectrometry (FTMS) methods affords additional information about complex chemical mixtures. Coeluted components can be resolved thanks to the ultrahigh resolving power, which ...
  • Pushing the analytical limits: new insights into complex mixtures using mass spectra segments of constant ultrahigh resolving power
    Palacio Lozano, Diana Catalina; Gavard, Remy; Arenas Diaz, Juan P.; Thomas, Mary J.; Stranz, David D.; Mejía-Ospino, Enrique; Guzman, Alexander; Spencer, Simon E.F.; Rossell, David; Barrow, Mark P. (Royal Society of Chemistry, 2019)
    A new strategy has been developed for characterization of the most challenging complex mixtures to date, using a combination of custom-designed experiments and a new data pre-processing algorithm. In contrast to traditional ...
  • Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
    Calon, Alexandre; Lonardo, Enza; Berenguer-Llergo, Antonio; Espinet, Elisa; Hernando-Momblona, Xavier; Iglesias Coma, Mar; Sevillano, Marta; Palomo-Ponce, Sergio; Tauriello, Daniele V.F.; Byrom, Daniel; Cortina Duran, Carme; Morral Martínez, Clara, 1989-; Barceló, Carles; Tosi, Sebastien; Riera, Antoni; Attolini, Camille Stephan-Otto; Rossell, David; Sancho, Elena; Batlle Gómez, Eduard (Nature Publishing Group, 2015)
    Recent molecular classifications of colorectal cancer (CRC) based on global gene expression profiles have defined subtypes displaying resistance to therapy and poor prognosis. Upon evaluation of these classification systems, ...
  • The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse
    Merlos-Suárez, Anna; Barriga de Vicente, Francisco Martín, 1983-; Jung, Peter; Iglesias Coma, Mar; Céspedes, María Virtudes; Rossell, David; Sevillano, Marta; Hernando-Momblona, Xavier; Silva-Diz, Victoria da; Muñoz, Purificación; Clevers, Hans; Sancho, Elena; Mangues, Ramon; Batlle Gómez, Eduard (Elsevier, 2011)
    A frequent complication in colorectal cancer (CRC) is regeneration of the tumor after therapy. Here, we report that a gene signature specific for adult intestinal stem cells (ISCs) predicts disease relapse in CRC patients. ...

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