Browsing by Author "Rodríguez de Fonseca, Fernando"

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  • Acetaminophen-induced liver injury alters the Acyl ethanolamine-based anti-inflammatory signaling system in liver
    Rivera, Patricia; Pastor, Antonio; Arrabal, Sergio; Decara, Juan M.; Vargas, Antonio; Sánchez-Marín, Laura; Pavón, Francisco Javier; Serrano, Antonia; Bautista, Dolores; Boronat Rigol, Anna, 1990-; Torre Fornell, Rafael de la; Baixeras, Elena; Lucena, Maria Isabel; Rodríguez de Fonseca, Fernando; Suárez, Juan (Frontiers, 2017)
    Protective mechanisms against drug-induced liver injury are actively being searched to identify new therapeutic targets. Among them, the anti-inflammatory N-acyl ethanolamide (NAE)-peroxisome proliferators activated receptor ...
  • Cannabinoid addiction: behavioral models and neural correlates
    Maldonado, Rafael, 1961-; Rodríguez de Fonseca, Fernando (Society for Neuroscience, 2002)
    The use of cannabis sativa preparations as recreational drugs can be traced back to the earliest civilizations. However, animal models of cannabinoid addiction allowing the exploration of neural correlates of cannabinoid ...
  • Comorbilidad psiquiátrica y valores plasmáticos de 2-acilgliceroles en consumidores de alcohol en tratamiento ambulatorio. Análisis de las diferencias de género
    García Marchena, Nuria; Araos, Pedro; Pavón, Francisco Javier; Ponce, Guillermo; Pedraz, María; Serrano, Antonia; Arias, Francisco; Romero Sanchiz, Pablo; Suárez, Juan; Pastor, Antonio; Torre Fornell, Rafael de la; Torrens, Marta; Rubio, Gabriel; Rodríguez de Fonseca, Fernando (Sociedad Científica Española de Estudios sobre el Alcohol, el Alcoholismo y las otras Toxicomanías, 2017)
    La adicción al alcohol se asocia con una elevada comorbilidad psiquiátrica que complica el tratamiento, siendo necesaria una fenotipación clínica objetiva de estos pacientes para optimizar la atención y mejorar el pronóstico. ...
  • Evaluation of plasma cytokines in patients with cocaine use disorders in abstinence identifies transforming growth factor alpha (TGFα) as a potential biomarker of consumption and dual diagnosis
    Maza-Quiroga, Rosa; García-Marchena, Nuria; Romero-Sanchiz, Pablo; Barrios, Vicente; Pedraz, María; Serrano, Antonia; Nogueira-Arjona, Raquel; Ruiz, Juan Jesús; Soria, Maribel; Campos Cloute, Rafael; Chowen, Julie A.; Argente, Jesús; Torrens, Marta; López-Gallardo, Meritxell; Marco, Eva María; Rodríguez de Fonseca, Fernando; Pavón, Francisco Javier; Araos, Pedro (PeerJ open, 2017)
    BACKGROUND: Cocaine use disorder (CUD) is a complex health condition, especially when it is accompanied by comorbid psychiatric disorders (dual diagnosis). Dual diagnosis is associated with difficulties in the stratification ...
  • Gender perspective in dual diagnosis
    Torrens, Marta; Orengo, Teresa; Rodríguez de Fonseca, Fernando; Almodóvar, Isabel; Baquero, Abel; Benito Salinas, Ana (MDPI, 2021)
    Little data are available for women diagnosed with a dual diagnosis. However, dual diagnosis in women presents increased stigma, social penalties, and barriers to access to treatment than it does for men. Indeed, it increases ...
  • Histone deacetylase gene expression following binge alcohol consumption in rats and humans
    López Moreno, José A.; Marcos, Miguel; Calleja Conde, Javier; Echeverry Alzate, Víctor; Bühler, Kora Mareen; Costa Alba, Pilar; Bernardo, Edgar; Laso, Francisco-Javier; Rodríguez de Fonseca, Fernando; Nadal, Roser; Viveros, Maria Paz; Maldonado, Rafael, 1961-; Giné, Elena (Wiley, 2015)
    BACKGROUND: Alcohol binge drinking is one of the most common patterns of excessive alcohol use and recent data would suggest that histone deacetylases (HDACs) gene expression profiling could be useful as a biomarker for ...
  • Inflammatory mediators and dual depression: potential biomarkers in plasma of primary and substance-induced major depression in cocaine and alcohol use disorders
    García Marchena, Nuria; Barrera, Marta; Mestre-Pintó, Juan Ignacio; Araos, Pedro; Serrano, Antonia; Pérez Mañá, Clara; Papaseit Fontanet, Esther; Fonseca Casals, Francina, 1972-; Ruiz, Juan Jesús; Rodríguez de Fonseca, Fernando; Farré Albaladejo, Magí; Pavón, Francisco Javier; Torrens, Marta (Public Library of Science (PLoS), 2019)
    Major depressive disorder (MDD) is the most prevalent comorbid mental disorder among people with substance use disorders. The MDD can be both primary and substance-induced and its accurate diagnosis represents a challenge ...
  • Nalmefene is effective at reducing alcohol seeking, treating alcohol-cocaine interactions and reducing alcohol-induced histone deacetylases gene expression in blood
    Calleja Conde, Javier; Echeverry Alzate, Víctor; Giné, Elena; Bühler, Kora Mareen; Nadal, Roser; Maldonado, Rafael, 1961-; Rodríguez de Fonseca, Fernando; Gual, Antoni; López Moreno, José A. (Wiley, 2016)
    BACKGROUND AND PURPOSE: The opioid antagonist nalmefene (selincro®) was approved for alcohol-related disorders by the European Medicines Agency in 2013. However, there have been no studies regarding the effectiveness of ...
  • Patients with alcohol use disorder: initial results from a prospective multicenter registry in the Spanish Network on Addiction Disorders. CohRTA Study
    Sanvisens, Arantza; Zuluaga, Paola; Rivas, Inmaculada; Rubio, Gabriel; Gual, Antoni; Torrens, Marta; Short, Antoni; Álvarez, Francisco Javier; Tor, Jordi; Farré, Magí; Rodríguez de Fonseca, Fernando; Muga, Roberto; CohRTA Study (Socidrogalcohol, 2018)
    The Alcohol Program of the Spanish Network on Addictive Disorders-RTA requires a longitudinal study to address different research questions related to alcoholism. The cohort study (CohRTA) focuses on patients seeking ...
  • Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothalamus and striatum in a negative energy context.
    Rivera, Patricia; Bindila, Laura; Pastor, Antonio; Pérez Martín, Margarita; Pavón, Francisco Javier; Serrano, Antonia; Torre Fornell, Rafael de la; Lutz, Beat; Rodríguez de Fonseca, Fernando; Suárez, Juan (Frontiers, 2015)
    Endocannabinoids participate in the control of neurogenesis, neural cell death and gliosis. The pharmacological effect of the fatty acid amide hydrolase (FAAH) inhibitor URB597, which limits the endocannabinoid degradation, ...
  • Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity
    García-Marchena, Nuria; Araos, Pedro; Barrios, Vicente; Sánchez-Marín, Laura; Chowen, Julie A.; Pedraz, María; Castilla Ortega, Estela; Romero-Sanchiz, Pablo; Ponce, Guillermo; Gavito, Ana L.; Decara, Juan M.; Silva Peña, Daniel; Torrens, Marta; Argente, Jesús; Rubio, Gabriel; Serrano, Antonia; Rodríguez de Fonseca, Fernando; Pavón, Francisco Javier (Frontiers, 2017)
    Recent studies have linked changes in peripheral chemokine concentrations to the presence of both addictive behaviors and psychiatric disorders. The present study further explore this link by analyzing the potential ...
  • Plasma Concentrations of BDNF and IGF-1 in Abstinent Cocaine Users with High Prevalence of Substance Use Disorders: Relationship to Psychiatric Comorbidity
    Pedraz, María; Martín Velasco, Ana Isabel; García Marchena, Nuria; Araos, Pedro; Serrano, Antonia; Romero Sanchiz, Pablo; Suárez, Juan; Castilla Ortega, Estela; Barrios, Vicente; Campos Cloute, Rafael; Ruiz, Juan Jesús; Torrens, Marta; Chowen, Julie A.; Argente, Jesús; Torre Fornell, Rafael de la; Santín, Luis Javier; Villanúa, María Ángeles; Rodríguez de Fonseca, Fernando; Pavón, Francisco Javier (Public Library of Science, 2015)
    Recent studies have identified biomarkers related to the severity and pathogenesis of cocaine addiction and common comorbid psychiatric disorders. Monitoring these plasma mediators may improve the stratification of cocaine ...
  • Plasma concentrations of oleoylethanolamide in a primary care sample of depressed patients are increased in those treated with selective serotonin reuptake inhibitor-type antidepressants
    Romero Sanchiz, Pablo; Nogueira-Arjona, Raquel; Pastor, Antonio; Araos, Pedro; Serrano, Antonia; Boronat Rigol, Anna, 1990-; García Marchena, Nuria; Mayoral, Fermín; Bordallo, Antonio; Alen, Francisco; Suárez, Juan; Torre Fornell, Rafael de la; Pavón, Francisco Javier; Rodríguez de Fonseca, Fernando (Elsevier, 2019)
    Oleoylethanolamide (OEA) is a non-cannabinoid acylethanolamide with multiple physiological roles that has been proposed to have antidepressant-like activity in preclinical models. OEA shares biosynthetic pathways with ...
  • Potential association of plasma lysophosphatidic acid (LPA) species with cognitive impairment in abstinent alcohol use disorders outpatients
    García Marchena, Nuria; Pizarro Lozano, Mª Nieves; Pavón, Francisco Javier; Martínez-Huélamo, Miriam; Flores López, María; Requena Ocaña, Nerea; Araos, Pedro; Silva Peña, Daniel; Suárez, Juan; Santín, Luis Javier; Torre Fornell, Rafael de la; Rodríguez de Fonseca, Fernando; Serrano, Antonia (Nature Research, 2020)
    Lysophosphatidic acid (LPA) species are bioactive lipids participating in neurodevelopmental processes. The aim was to investigate whether the relevant species of LPA were associated with clinical features of alcohol ...
  • Red Bull® energy drink increases consumption of higher concentrations of alcohol
    Roldán, Marta; Echeverry Alzate, Víctor; Bühler, Kora Mareen; Sánchez Diez, Israel J.; Calleja Conde, Javier; Olmos, Pedro; Boehm, Stephen L.; Maldonado, Rafael, 1961-; Rodríguez de Fonseca, Fernando; Santiago, Catalina; Gómez Gallego, Felix; Giné, Elena; López Moreno, José A. (Wiley-Blackwell, 2018)
    Mixing alcohol with caffeinated energy drinks is a common practice, especially among young people. In humans, the research on this issue has mainly focused on the use of the mass-marketed energy drinks themselves, whereas ...
  • Sex differences in plasma Lysophosphatidic Acid Species in patients with alcohol and cocaine use disorders
    Flores López, María; García-Marchena, Nuria; Araos, Pedro; Requena-Ocaña, Nerea; Porras-Perales, Oscar; Torres-Galván, Sandra; Suárez, Juan; Pizarro Lozano, Mª Nieves; Torre Fornell, Rafael de la; Rubio, Gabriel; Ruiz-Ruiz, Juan Jesús; Rodríguez de Fonseca, Fernando; Serrano, Antonia; Pavón-Morón, Francisco Javier (MDPI, 2022)
    Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder ...
  • Sex differences in psychiatric comorbidity and plasma biomarkers for cocaine addiction in abstinent cocaine-addicted subjects in outpatient settings
    Pedraz, María; Araos, Pedro; García Marchena, Nuria; Serrano, Antonia; Romero Sanchiz, Pablo; Suárez, Juan; Castilla Ortega, Estela; Mayoral Cleries, Fermín; Ruiz, Juan Jesús; Pastor, Antonio; Barrios, Vicente; Chowen, Julie A.; Argente, Jesús; Torrens, Marta; Torre Fornell, Rafael de la; Rodríguez de Fonseca, Fernando; Pavón, Francisco Javier (Frontiers, 2015)
    There are sex differences in the progression of drug addiction, relapse, and response to therapies. Because biological factors participate in these differences, they should be considered when using biomarkers for addiction. ...
  • The systemic administration of oleoylethanolamide exerts neuroprotection of the nigrostriatal system in experimental Parkinsonism
    González-Aparicio, Ramiro; Blanco, Eduardo; Serrano, Antonia; Pavón, Francisco Javier; Parsons, Loren H.; Maldonado, Rafael, 1961-; Robledo, Patricia, 1958-; Fernández-Espejo, Emilio; Rodríguez de Fonseca, Fernando (Oxford University Press, 2014)
    Oleoylethanolamide (OEA) is an agonist of the peroxisome proliferator-activated receptor α (PPARα) and has been described to exhibit neuroprotective properties when administered locally in animal models of several neurological ...
  • Trastorno por uso de cocaína y depresión: cuando el diagnóstico clínico no es suficiente
    Alías i Ferri, María; García-Marchena, Nuria; Mestre-Pintó, Juan Ignacio; Araos, Pedro; Vergara-Moragues, Esperanza; Fonseca Casals, Francina, 1972-; González-Saiz, Francisco; Rodríguez de Fonseca, Fernando; Torrens, Marta; The NEURODEP Group (Socidrogalcohol, 2021)
    Antecedentes: El consumo de cocaína es un creciente problema de salud en todo el mundo. Además, los pacientes con trastorno por consumo de cocaína (TCC) presentan una alta comorbilidad con el trastorno depresivo mayor ...
  • Treatment with a novel oleic-acid-dihydroxyamphetamine conjugation ameliorates non-alcoholic fatty liver disease in obese Zucker rats.
    Decara, Juan M.; Pavón, Francisco Javier; Suárez, Juan; Romero-Cuevas, Miguel; Baixeras, Elena; Vázquez, Mariam; Rivera, Patricia; Gavito, Ana L.; Almeida Cotrim, Bruno; Joglar Tamargo, Jesús; Torre Fornell, Rafael de la; Rodríguez de Fonseca, Fernando; Serrano, Antonia (Company of Biologists, 2015)
    Fatty liver disease is one of the main hepatic complications associated with obesity. To date, there are no effective treatments for this pathology apart from the use of classical fibrates. In this study, we have characterized ...