Browsing by Author "Rinaldi, Lorenzo, 1986-"

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  • Rinaldi, Lorenzo, 1986-; Datta, Debayan; Serrat, Judit; Morey Ramonell, Lluís; Solanas, Guiomar; Avgustinova, Alexandra; Blanco, Enrique; Pons, José Ignacio; Matallanas, David; Kriegsheim, Alex von; Di Croce, Luciano; Aznar Benitah, Salvador (Elsevier, 2016)
    The genome-wide localization and function of endogenous Dnmt3a and Dnmt3b in adult stem cells are unknown. Here, we show that in human epidermal stem cells, the two proteins bind in a histone H3K36me3-dependent manner to ...
  • Rinaldi, Lorenzo, 1986- (Universitat Pompeu Fabra, 2016-10-17)
    DNA methylation is an essential epigenetic mechanism that regulates gene expression. While DNA methylation dynamics during embryonic formation is fairly well understood, its role in adult tissues is still under investigation. ...
  • Martinelli, Paola; Carrillo, Enrique; Cox, Trevor; Sainz, Bruno Jr; Dusetti, Nelson; Greenhalf, William; Rinaldi, Lorenzo, 1986-; Costello, Eithne; Ghaneh, Paula; Malats i Riera, Núria; Büchler, Markus; Pajic, Marina; Biankin, Andrew V.; Iovanna, Juan; Neoptolemos, John; Real, Francisco X. (BMJ Publishing Group, 2017)
    BACKGROUND AND AIMS: The role of GATA factors in cancer has gained increasing attention recently, but the function of GATA6 in pancreatic ductal adenocarcinoma (PDAC) is controversial. GATA6 is amplified in a subset of ...
  • Rinaldi, Lorenzo, 1986-; Avgustinova, Alexandra; Martín, Mercè; Datta, Debayan; Solanas, Guiomar; Prats, Neus; Aznar Benitah, Salvador (eLife, 2017)
    The DNA methyltransferase Dnmt3a suppresses tumorigenesis in models of leukemia and lung cancer. Conversely, deregulation of Dnmt3b is thought to generally promote tumorigenesis. However, the role of Dnmt3a and Dnmt3b in ...