Browsing by Author "Riera Oliva, Marta"

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  • Activation of final complement components after kidney transplantation as a marker of delayed graft function severity
    Arias Cabrales, Carlos Enrique; Riera Oliva, Marta; Pérez-Sáez, María José; Gimeno Beltran, Javier; Benito, David; Redondo Pachón, María Dolores; Burballa Tàrrega, Carla, 1988-; Crespo Barrio, Marta; Pascual Santos, Julio; Rodríguez, Eva (Oxford University Press, 2020)
    Background: Ischaemia-reperfusion (I/R) damage is a relevant cause of delayed graft function (DGF). Complement activation is involved in experimental I/R injury, but few data are available from kidney transplant (KT) ...
  • Characterization of ACE and ACE2 Expression within Different Organs of the NOD Mouse
    Roca-Ho, Heleia; Riera Oliva, Marta; Palau González, Vanesa; Pascual Santos, Julio; Soler, María José (MDPI, 2017)
    Renin angiotensin system (RAS) is known to play a key role in several diseases such as diabetes, and renal and cardiovascular pathologies. Its blockade has been demonstrated to delay chronic kidney disease progression and ...
  • Effect of insulin on ACE2 activity and kidney function in the non-obese diabetic mouse (PLoS ONE (2014))
    Riera Oliva, Marta; Márquez, Eva; Clotet, Sergi; Gimeno Beltran, Javier; Roca-Ho, Heleia; Lloreta Trull, Josep, 1958-; Juanpere, Nuria; Batlle, Daniel; Pascual Santos, Julio; Soler, María José (Public Library of Science (PLoS), 2014)
    We studied the non-obese diabetic (NOD) mice model because it develops autoimmune diabetes that resembles human type 1 diabetes. In diabetic mice, urinary albumin excretion (UAE) was ten-fold increased at an “early stage” ...
  • Endothelial ADAM17 expression in the progression of kidney injury in an obese mouse model of pre-diabetes
    Palau González, Vanesa; Jarrín, Josué; Villanueva, Sofia; Benito, David; Márquez, Eva; Rodríguez, Eva; Soler, María José; Oliveras, Anna; Gimeno, Javier; Sans Atxer, Laia; Crespo Barrio, Marta; Pascual Santos, Julio; Barrios Barrera, Clara; Riera Oliva, Marta (MDPI, 2021)
    Disintegrin and metalloproteinase domain 17 (ADAM17) activates inflammatory and fibrotic processes through the shedding of various molecules such as Tumor Necrosis Factor-α (TNF-α) or Transforming Growht Factor-α (TGF-α). ...
  • Endothelin Blockade in Diabetic Kidney Disease.
    Anguiano Gómez, Lidia; Riera Oliva, Marta; Pascual Santos, Julio; Soler, María José (MDPI, 2015)
    Diabetic kidney disease (DKD) remains the most common cause of chronic kidney disease and multiple therapeutic agents, primarily targeted at the renin-angiotensin system, have been assessed. Their only partial effectiveness ...
  • Exploring renal changes after bariatric surgery in patients with severe obesity
    Oliveras, Anna; Vázquez, Susana; Soler, María José; Galceran Herrera, Isabel; Duran Jordà, Xavier, 1974-; Goday Arno, Alberto; Benaiges Foix, David; Crespo Barrio, Marta; Pascual Santos, Julio; Riera Oliva, Marta (MDPI, 2022)
    Obesity-related hyperfiltration leads to an increased glomerular filtration rate (GFR) and hyperalbuminuria. These changes are reversible after bariatric surgery (BS). We aimed to explore obesity-related renal changes ...
  • Gonadectomy prevents the increase in blood pressure and glomerular injury in angiotensin-converting enzyme 2 knockout diabetic male mice. Effects on renin-angiotensin system.
    Clotet, Sergi; Soler, María José; Rebull, Marta; Gimeno Beltran, Javier; Gurley, Susan Bailey; Pascual Santos, Julio; Riera Oliva, Marta (Lippincott Williams & Wilkins, 2016)
    BACKGROUND: Angiotensin-converting enzyme 2 (ACE2) deletion worsens kidney injury, and its amplification ameliorates diabetic nephropathy. Male sex increases the incidence, prevalence, and progression of chronic kidney ...
  • Membrane attack complex and factor H in humans with acute kidney injury
    Rodriguez García, Eva; Gimeno Beltran, Javier; Arias Cabrales, Carlos Enrique; Barrios Barrera, Clara; Redondo Pachón, María Dolores; Soler, María José; Crespo Barrio, Marta; Sierra Ochoa, Adriana; Riera Oliva, Marta; Pascual Santos, Julio (Karger (S. Karger AG), 2018)
    BACKGROUND AND AIMS: Complement system seems to play an important role in the pathogenesis of Acute Kidney Injury (AKI). The aim of this study was to investigate the role of complement system in the pathogenesis of human ...
  • MMP-10 is increased in early stage diabetic kidney disease and can be reduced by renin-angiotensin system blockade
    Mora-Gutiérrez, José María; Rodríguez, José Antonio; Fernández-Seara, María A.; Orbe, Josune; Escalada, Francisco Javier; Soler, María José; Slon Roblero, María Fernanda; Riera Oliva, Marta; Páramo, José Antonio; García-Fernández, Nuria (Nature Research, 2020)
    Matrix metalloproteinases have been implicated in diabetic microvascular complications. However, little is known about the pathophysiological links between MMP-10 and the renin-angiotensin system (RAS) in diabetic kidney ...
  • Mortality in hemodialysis patients with COVID-19, the effect of paricalcitol or calcimimetics
    Arenas Jiménez, María Dolores; Riera Oliva, Marta; Cao Baduell, Higinio; Collado Nieto, Silvia; Barbosa Puig, Francisco; Nogués Solan, Francesc Xavier; Marta Crespo; Pascual Santos, Julio (MDPI, 2021)
    Background: In COVID-19 patients, low serum vitamin D (VD) levels have been associated with severe acute respiratory failure and poor prognosis. In regular hemodialysis (HD) patients, there is VD deficiency and markedly ...
  • Redefining the role of ADAM17 in renal proximal tubular cells and its implications in an obese mouse model of pre-diabetes
    Palau González, Vanesa; Villanueva, Sofia; Jarrín, Josué; Benito, David; Márquez, Eva; Rodríguez, Eva; Soler, María José; Oliveras, Anna; Gimeno Beltran, Javier; Sans Atxer, Laia; Crespo Barrio, Marta; Pascual Santos, Julio; Barrios Barrera, Clara; Riera Oliva, Marta (MDPI, 2021)
    Acute and chronic kidney lesions induce an increase in A Disintegrin And Metalloproteinase domain 17 (ADAM17) that cleaves several transmembrane proteins related to inflammatory and fibrotic pathways. Our group has ...
  • Role of ADAM17 in kidney disease
    Palau González, Vanesa; Pascual Santos, Julio; Soler, María José; Riera Oliva, Marta (American Physiological Society, 2019)
    It is known that the renin-angiotensin system plays a major role in the pathophysiology of cardiovascular disease and renal injury. Within the renin-angiotensin system, angiotensin-converting enzyme 2 (ACE2) cleaves ANG ...
  • The Role of Kindlin-2 in the progression of renal fibrosis
    Jan, Budour H. (Universitat Pompeu Fabra, 2018-05-10)
    Chronic kidney disease (CKD) is usually characterized by histological lesions of glomerulosclerosis and tubulointerstitial fibrosis (TIF). The progressive TIF is mediated by multiple mediators such as growth factors, ...

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